YRC Public Data Repository - Protein Structure Prediction

Protein:	HIPB_ECOLI
Organism:	Escherichia coli
Length:	88 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIPB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|25519852 - pir\|\|D97388 probable DNA-binding protein (AL138598) [imported] - Agrobacterium tumefaciens (strain C... gi\|15887595, gi\|... - gi\|15887595\|ref\|NP_353276.1\| hypothetical protein AGR_C_418 [Agrobacterium tumefaciens str. C58], gi...	92.0	[0..1]	[87..12]
gi\|25490641 - pir\|\|E84013 hypothetical protein BH2909 [imported] - Bacillus halodurans (strain C-125) gi\|10175531, gi\|... - gi\|15615472\|ref\|NP_243775.1\| hypothetical protein BH2909 [Bacillus halodurans C-125], gi\|10175531\|db...	92.0	[0..2]	[85..1]
gi\|116250024, gi... - gi\|116250024\|ref\|YP_765862.1\| putative transcriptional regulator [Rhizobium leguminosarum bv. viciae...	91.0	[0..1]	[87..1]
gi\|86355908, gi\|... - gi\|86355908\|ref\|YP_467800.1\| LacI family transcription regulator [Rhizobium etli CFN 42], gi\|8628001...	89.0	[0..5]	[87..1]
gi\|83951416, gi\|... - gi\|83951416\|ref\|ZP_00960148.1\| probable transcriptional regulator [Roseovarius nubinhibens ISM], gi\|...	89.0	[0..1]	[86..16]
gi\|227554043, gi... - gi\|227554043\|ref\|ZP_03984090.1\| transcriptional regulator [Enterococcus faecalis HH22], gi\|227176791... gi\|29344465, gi\|... - gi\|29376999\|ref\|NP_816153.1\| Cro/CI family transcriptional regulator [Enterococcus faecalis V583], g...	88.0	[0..7]	[87..1]
gi\|78363968, gi\|... - gi\|78485682\|ref\|YP_391607.1\| XRE family transcriptional regulator [Thiomicrospira crunogena XCL-2], ...	88.0	[0..1]	[87..1]
gi\|160875134, gi... - gi\|160875134\|ref\|YP_001554450.1\| putative phage repressor [Shewanella baltica OS195], gi\|160860656\|g...	87.0	[0..10]	[88..1]
gi\|91191378, gi\|... - gi\|91223886\|ref\|ZP_01259150.1\| putative transcriptional regulator [Vibrio alginolyticus 12G01], gi\|9...	87.0	[0..10]	[83..3]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSFQKIYSP TQLANAMKLV RQQNGWTQSE LAKKIGIKQA TISNFENNPD NTTLTTFFKI  60
   61 LQSLELSMTL CDAKNASPES TEQQNLEW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1y9qA
Description:	Crystal Structure of HTH_3 family Transcriptional Regulator from Vibrio cholerae
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	3.60509310049517	bayes_pls_golite062009
transcription regulator activity	3.48897156115814	bayes_pls_golite062009
nucleic acid binding	3.34114111237501	bayes_pls_golite062009
binding	2.84855827811506	bayes_pls_golite062009
transcription factor activity	2.15956406789231	bayes_pls_golite062009
catalytic activity	0.374904657353081	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29966985317584	bayes_pls_golite062009
sequence-specific DNA binding	0.11459677079129	bayes_pls_golite062009
transcription repressor activity	0.0485771867742395	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: