YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|147761735, gi...
Organism:	Streptococcus pneumoniae SP18-BS74
Length:	428 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|147761735, gi....

Description	E-value	Query Range	Subject Range
PURA_STRP3 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) GN... PURA_STRPQ - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 (strain SSI-1) GN=purA PE=3 SV=1 PURA_STRP3 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M3 GN=purA PE=3 SV=1	723.0	[0..1]	[428..1]
PURA_STRPM - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M28 GN=purA PE=3 SV=1 PURA_STRPM - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M28 (strain MGAS6180) GN=purA PE=3 SV... PURA_STRPD - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M2 (strain MGAS10270) GN=purA PE=3 SV...	722.0	[0..1]	[428..1]
PURA_STRP1 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M1 GN=purA PE=3 SV=1 gi\|13621455, gi\|... - gi\|15674367\|ref\|NP_268541.1\| adenylosuccinate synthetase [Streptococcus pyogenes M1 GAS], gi\|1362145... PURA_STRPY - (Q9A1P8) Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)	721.0	[0..1]	[428..1]
gi\|66877603, gi\|... - gi\|66877603\|ref\|ZP_00403146.1\| COG0104: Adenylosuccinate synthase [Streptococcus pneumoniae TIGR4], ...	721.0	[0..1]	[428..15]
PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 GN=purA PE=3 SV=1 PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=purA PE=3 SV... PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 GN=purA PE=3 SV=1 PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) ...	720.0	[0..1]	[428..1]
PURA_STRPC - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M12 (strain MGAS9429) GN=purA PE=3 SV... gi\|71909950, gi\|... - gi\|71909950\|ref\|YP_281500.1\| adenylosuccinate synthetase [Streptococcus pyogenes MGAS5005], gi\|71852...	718.0	[0..1]	[428..1]
PURA_STRT1 - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain CNRZ 1066) GN=purA PE=3 SV=1 PURA_STRT2 - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) GN=purA ... gi\|55737896, gi\|... - gb\|AAV63453.1\| adenylosuccinate synthetase [Streptococcus thermophilus CNRZ1066], gb\|AAV61538.1\| ad...	717.0	[0..1]	[428..1]
PURA_STRPF - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M4 (strain MGAS10750) GN=purA PE=3 SV...	717.0	[0..1]	[428..1]
PURA_STRTD - Adenylosuccinate synthetase OS=Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9) GN=purA PE=3...	717.0	[0..1]	[428..1]
gi\|77159680, gi\|... - gi\|77414264\|ref\|ZP_00790424.1\| adenylosuccinate synthetase [Streptococcus agalactiae 515], gi\|771596... PURA_STRA3 - Adenylosuccinate synthetase OS=Streptococcus agalactiae serotype III GN=purA PE=3 SV=1 gi\|77408417, gi\|... - gi\|77408417\|ref\|ZP_00785156.1\| adenylosuccinate synthetase [Streptococcus agalactiae COH1], gi\|77172... gi\|76586283, gi\|... - gi\|76798369\|ref\|ZP_00780612.1\| adenylosuccinate synthetase [Streptococcus agalactiae 18RS21], gi\|765... PURA_STRA3 - Adenylosuccinate synthetase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=purA PE=3 SV... PURA_STRA5 - Adenylosuccinate synthetase OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) ... PURA_STRA5 - Adenylosuccinate synthetase OS=Streptococcus agalactiae serotype V GN=purA PE=3 SV=1	714.0	[0..1]	[428..1]

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Predicted Domain #1

Region A:
Residues: [1-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSVVVVGTQ WGDEGKGKIT DFLSANAEVI ARYQGGDNAG HTIVIDGKKF KLHLIPSGIF  60
   61 FPEKISVIGN GMVVNPKSLV KELSYLHEEG VTTDNLRISD RAHVILPYHI ELDRLQEEAK 120
  121 GDNKIGTTIK GIGPAYMDKA ARVGIRIADL LDKDIFRERL ERNLAEKNRL FEKLYDSKAI 180
  181 VFDDIFEEYY EYGQQIKKYV IDTSVILNDA LDNGKRVLFE GAQGVMLDID QGTYPFVTSS 240
  241 NPVAGGVTIG SGVGPSKIDK VVGVCKAYTS RVGDGPFPTE LFDEVGERIR EVGHEYGTTT 300
  301 GRPRRVGWFD SVVMRHSRRV SGITNLSLNS IDVLSGLDTV KICVAYDLDG QRIDYYPASL 360
  361 EQLKRCKPIY EELPGWSEDI TGVRNLEDLP ENARNYVRRV SELVGVRIST FSVGPGREQT 420
  421 NILESVWS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1kjxA
Description:	Adenylosuccinate synthetase, PurA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	1.24165037431695	bayes_pls_golite062009
purine ribonucleotide binding	1.1110976601505	bayes_pls_golite062009
ribonucleotide binding	1.11103644113672	bayes_pls_golite062009
purine nucleotide binding	1.1086792521709	bayes_pls_golite062009
nucleotide binding	1.1060655022247	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.80197288940364	bayes_pls_golite062009
adenyl ribonucleotide binding	0.770085840885632	bayes_pls_golite062009
adenyl nucleotide binding	0.751575230566049	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
kinase activity	0.431162005044036	bayes_pls_golite062009
structural constituent of ribosome	0.396187998943318	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.277694966071518	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.250756824614616	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.126821629333317	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: