YRC Public Data Repository - Protein Structure Prediction

Protein:	GABP_ECOLI
Organism:	Escherichia coli
Length:	466 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GABP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|42548077, gi\|... - gi\|46115934\|ref\|XP_383985.1\| hypothetical protein FG03809.1 [Gibberella zeae PH-1], gi\|42548077\|gb\|E...	314.0	[0..4]	[466..1095]
gi\|238482071, gi... - gi\|238482071\|ref\|XP_002372274.1\| amino acid permease (Gap1), putative [Aspergillus flavus NRRL3357],... gi\|169765514 - gi\|169765514\|ref\|XP_001817228.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83765083 - gi\|83765083\|dbj\|BAE55226.1\| unnamed protein product [Aspergillus oryzae]	309.0	[0..2]	[466..70]
gi\|39943728, gi\|... - gi\|39943728\|ref\|XP_361401.1\| hypothetical protein MG03875.4 [Magnaporthe grisea 70-15], gb\|EAA50116....	308.0	[0..8]	[466..39]
gi\|85095443 - gi\|85095443\|ref\|XP_960090.1\| general amino-acid permease GAP1 [Neurospora crassa OR74A] gi\|32410409, gi\|... - gi\|32410409\|ref\|XP_325685.1\| hypothetical protein [Neurospora crassa], gi\|28921549\|gb\|EAA30854.1\| ge...	307.0	[0..10]	[464..145]
GNP1_YEAST - High-affinity glutamine permease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GNP1 PE... GNP1 - High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is ful...	303.0	[0..2]	[459..137]
gi\|50292087, gi\|... - gi\|50292087\|ref\|XP_448476.1\| unnamed protein product [Candida glabrata], gi\|49527788\|emb\|CAG61437.1\|... gi\|49527788 - gi\|49527788\|emb\|CAG61437.1\| unnamed protein product [Candida glabrata]	301.0	[0..6]	[459..138]
gi\|114193057, gi... - gi\|115395202\|ref\|XP_001213488.1\| general amino-acid permease GAP1 [Aspergillus terreus NIH2624], gi\|...	301.0	[0..4]	[466..70]
gi\|90301547, gi\|... - gi\|90301547\|gb\|EAS31178.1\| hypothetical protein CIMG_06657 [Coccidioides immitis RS], gi\|119183443\|r...	301.0	[0..1]	[465..63]

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Predicted Domain #1

Region A:
Residues: [1-391]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQSSQPHEL GGGLKSRHVT MLSIAGVIGA SLFVGSSVAI AEAGPAVLLA YLFAGLLVVM  60
   61 IMRMLAEMAV ATPDTGSFST YADKAIGRWA GYTIGWLYWW FWVLVIPLEA NIAAMILHSW 120
  121 VPGIPIWLFS LVITLALTGS NLLSVKNYGE FEFWLALCKV IAILAFIFLG AVAISGFYPY 180
  181 AEVSGISRLW DSGGFMPNGF GAVLSAMLIT MFSFMGAEIV TIAAAESDTP EKHIVRATNS 240
  241 VIWRISIFYL CSIFVVVALI PWNMPGLKAV GSYRSVLELL NIPHAKLIMD CVILLSVTSC 300
  301 LNSALYTASR MLYSLSRRGD APAVMGKINR SKTPYVAVLL STGAAFLTVV VNYYAPAKVF 360
  361 KFLIDSSGAI ALLVYLVIAV SQLRMRKILR A

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.33
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
amine transmembrane transporter activity	5.15069657292327	bayes_pls_golite062009
amino acid transmembrane transporter activity	4.54752581624334	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	4.39427743642027	bayes_pls_golite062009
organic acid transmembrane transporter activity	4.356142166703	bayes_pls_golite062009
transporter activity	3.46503611631839	bayes_pls_golite062009
transmembrane transporter activity	3.34431027577801	bayes_pls_golite062009
substrate-specific transporter activity	3.08398439124803	bayes_pls_golite062009
active transmembrane transporter activity	2.98812190037621	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.96577701947757	bayes_pls_golite062009
ion transmembrane transporter activity	1.89542769737674	bayes_pls_golite062009
organic acid:sodium symporter activity	1.82263833070018	bayes_pls_golite062009
L-amino acid transmembrane transporter activity	1.79964917042361	bayes_pls_golite062009
cation transmembrane transporter activity	1.79923665576923	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	1.71764370341895	bayes_pls_golite062009
monoamine transmembrane transporter activity	1.59349600647168	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.37015067735708	bayes_pls_golite062009
symporter activity	1.31198147603118	bayes_pls_golite062009
solute:cation symporter activity	1.31198147603118	bayes_pls_golite062009
solute:sodium symporter activity	0.868753445363102	bayes_pls_golite062009
neurotransmitter:sodium symporter activity	0.658077875061275	bayes_pls_golite062009
binding	0.299468111884938	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [392-466]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGSEIRLRMW LYPWLTWLVI GFITFVLVVM LFRPAQQLEV ISTGLLAIGI ICTVPIMARW  60
   61 KKLVLWQKTP VHNTR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: