YRC Public Data Repository - Protein Structure Prediction

Protein:	G6PD_ECOLI
Organism:	Escherichia coli
Length:	491 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for G6PD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|119767447, gi... - gi\|68548046\|ref\|ZP_00587566.1\| Glucose-6-phosphate dehydrogenase [Shewanella amazonensis SB2B], gi\|6...	693.0	[0..7]	[489..8]
gi\|226900562, gi... - gi\|237705805\|ref\|ZP_04536286.1\| glucose-6-phosphate dehydrogenase [Escherichia sp. 3_2_53FAA], gi\|22... gi\|218558717, gi... - gi\|218558717\|ref\|YP_002391630.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli S88], gi\|2183... gi\|91211076, gi\|... - gi\|91211076\|ref\|YP_541062.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli UTI89], gi\|910726... gi\|117624004, gi... - gi\|117624004\|ref\|YP_852917.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli APEC O1], gi\|115...	692.0	[0..1]	[491..1]
gi\|74311825, gi\|... - gi\|74311825\|ref\|YP_310244.1\| glucose-6-phosphate 1-dehydrogenase [Shigella sonnei Ss046], gi\|7385530... gi\|81245087, gi\|... - gi\|82543676\|ref\|YP_407623.1\| glucose-6-phosphate 1-dehydrogenase [Shigella boydii Sb227], gi\|8124508... gi\|209912477, gi... - gi\|209919218\|ref\|YP_002293302.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli SE11], gi\|209... gi\|242377573, gi... - gi\|251785300\|ref\|YP_002999604.1\| hypothetical protein B21_01811 [Escherichia coli BL21], gi\|24237757... gi\|218554426, gi... - gi\|218554426\|ref\|YP_002387339.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli IAI1], gi\|218... gi\|254161912, gi... - gi\|254161912\|ref\|YP_003045020.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli B str. REL606... gi\|194417835, gi... - gi\|194433963\|ref\|ZP_03066235.1\| glucose-6-phosphate 1-dehydrogenase [Shigella dysenteriae 1012], gi\|... gi\|253773192, gi... - gi\|254288700\|ref\|YP_003054448.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli BL21(DE3)], g... gi\|194422045, gi... - gi\|83585547\|ref\|ZP_00924191.1\| COG0364: Glucose-6-phosphate 1-dehydrogenase [Escherichia coli 101-1]... gi\|75175690, gi\|... - gi\|75175690\|ref\|ZP_00695896.1\| COG0364: Glucose-6-phosphate 1-dehydrogenase [Shigella boydii BS512],... gi\|218695418, gi... - gi\|218695418\|ref\|YP_002403085.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli 55989], gi\|21...	692.0	[0..1]	[491..1]
gi\|114047425, gi... - gi\|114047425\|ref\|YP_737975.1\| glucose-6-phosphate 1-dehydrogenase [Shewanella sp. MR-7], gi\|11388886... gi\|113885067, gi... - gi\|82498013\|ref\|ZP_00883531.1\| Glucose-6-phosphate dehydrogenase [Shewanella sp. MR-4], gi\|82403981\|...	691.0	[0..7]	[489..8]
gi\|168777752, gi... - gi\|187767081\|gb\|EDU30925.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC419... gi\|168770834, gi... - gi\|189360306\|gb\|EDU78725.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC448... gi\|168758567, gi... - gi\|189354614\|gb\|EDU73033.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC440... gi\|188013981, gi... - gi\|188013981\|gb\|EDU52103.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC411... gi\|208724726, gi... - gi\|208810210\|ref\|ZP_03252086.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. E... gi\|189375635, gi... - gi\|189375635\|gb\|EDU94051.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC508... gi\|168788272, gi... - gi\|189372071\|gb\|EDU90487.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC869... gi\|168783152, gi... - gi\|188999419\|gb\|EDU68405.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. EC407... gi\|254592876, gi... - gi\|254793476\|ref\|YP_003078313.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. ... gi\|13362030, gi\|... - gi\|15831816\|ref\|NP_310589.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. Saka... G6PD_ECO57 - Glucose-6-phosphate 1-dehydrogenase OS=Escherichia coli O157:H7 GN=zwf PE=3 SV=1 gi\|217318316, gi... - gi\|217328969\|ref\|ZP_03445050.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. T... gi\|209767558, gi... - pir\|\|F85797 glucose-6-phosphate dehydrogenase [imported] - Escherichia coli (strain O157:H7, substra... gi\|209396330, gi... - gi\|209396330\|ref\|YP_002270934.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. ... gi\|208739326, gi... - gi\|208819203\|ref\|ZP_03259523.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. E... gi\|12515905, gi\|... - gi\|15802265\|ref\|NP_288289.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 EDL933], ... gi\|208816599, gi... - gi\|208816599\|ref\|ZP_03257719.1\| glucose-6-phosphate 1-dehydrogenase [Escherichia coli O157:H7 str. E...	691.0	[0..1]	[491..1]
gi\|194412287, gi... - gi\|75209102\|ref\|ZP_00709357.1\| COG0364: Glucose-6-phosphate 1-dehydrogenase [Escherichia coli B171],...	691.0	[0..1]	[491..1]
gi\|145598351, gi... - gi\|145598351\|ref\|YP_001162427.1\| glucose-6-phosphate 1-dehydrogenase [Yersinia pestis Pestoides F], ... gi\|117673642, gi... - gi\|77629132\|ref\|ZP_00791718.1\| COG0364: Glucose-6-phosphate 1-dehydrogenase [Yersinia pseudotubercul... gi\|169750902, gi... - gi\|170024368\|ref\|YP_001720873.1\| glucose-6-phosphate 1-dehydrogenase [Yersinia pseudotuberculosis YP... gi\|186895417, gi... - gi\|186895417\|ref\|YP_001872529.1\| glucose-6-phosphate 1-dehydrogenase [Yersinia pseudotuberculosis PB... Q66AT1\|Q66AT1_YERPS - Glucose-6-phosphate 1-dehydrogenase - Yersinia pseudotuberculosis gi\|51589657, gi\|... - gi\|51596375\|ref\|YP_070566.1\| glucose-6-phosphate 1-dehydrogenase [Yersinia pseudotuberculosis IP 329...	691.0	[0..1]	[491..4]
gi\|25283741 - pir\|\|AH3573 glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) [imported] - Brucella melitensis (stra... gi\|17984682, gi\|... - gi\|17988858\|ref\|NP_541491.1\| glucose-6-phosphate 1-dehydrogenase [Brucella melitensis 16M], gi\|17984... gi\|225686545, gi... - gi\|225686545\|ref\|YP_002734517.1\| glucose-6-phosphate 1-dehydrogenase [Brucella melitensis ATCC 23457...	690.0	[0..2]	[489..3]
gi\|110615344, gi... - gi\|110805796\|ref\|YP_689316.1\| glucose-6-phosphate 1-dehydrogenase [Shigella flexneri 5 str. 8401], g... gi\|30063263, gi\|... - gi\|30063263\|ref\|NP_837434.1\| glucose-6-phosphate 1-dehydrogenase [Shigella flexneri 2a str. 2457T], ...	690.0	[0..1]	[491..1]
gi\|148370067, gi... - gi\|148558782\|ref\|YP_001257725.1\| glucose-6-phosphate 1-dehydrogenase [Brucella ovis ATCC 25840], gi\|... gi\|62197578, gi\|... - gi\|62317385\|ref\|YP_223238.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus bv. 1 str. 9-941]... gi\|83269363 - gi\|83269363\|ref\|YP_418654.1\| glucose-6-phosphate 1-dehydrogenase [Brucella melitensis biovar Abortus... gi\|82939637 - gi\|82939637\|emb\|CAJ12626.1\| Glucose-6-phosphate dehydrogenase [Brucella melitensis biovar Abortus 23... gi\|189021213, gi... - gi\|189022639\|ref\|YP_001932380.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus S19], gi\|1890... gi\|254690886 - gi\|254690886\|ref\|ZP_05154140.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus bv. 6 str. 870... gi\|254695803 - gi\|254695803\|ref\|ZP_05157631.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus bv. 3 str. Tul... gi\|225629252, gi... - gi\|225629252\|ref\|ZP_03787285.1\| glucose-6-phosphate 1-dehydrogenase [Brucella ceti str. Cudo], gi\|22... gi\|237816938, gi... - gi\|237816938\|ref\|ZP_04595930.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus str. 2308 A], ... gi\|254705744 - gi\|254705744\|ref\|ZP_05167572.1\| glucose-6-phosphate 1-dehydrogenase [Brucella pinnipedialis M163/99/... gi\|254710976 - gi\|254710976\|ref\|ZP_05172787.1\| glucose-6-phosphate 1-dehydrogenase [Brucella pinnipedialis B2/94] gi\|254698667 - gi\|254698667\|ref\|ZP_05160495.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus bv. 2 str. 86/... gi\|254699991 - gi\|254699991\|ref\|ZP_05161819.1\| glucose-6-phosphate 1-dehydrogenase [Brucella suis bv. 5 str. 513] gi\|254732114 - gi\|254732114\|ref\|ZP_05190692.1\| glucose-6-phosphate 1-dehydrogenase [Brucella abortus bv. 4 str. 292... gi\|254712552 - gi\|254712552\|ref\|ZP_05174363.1\| glucose-6-phosphate 1-dehydrogenase [Brucella ceti M644/93/1] gi\|254715624 - gi\|254715624\|ref\|ZP_05177435.1\| glucose-6-phosphate 1-dehydrogenase [Brucella ceti M13/05/1]	690.0	[0..2]	[489..3]

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Predicted Domain #1

Region A:
Residues: [1-491]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVTQTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGQLN PDTRIIGVGR ADWDKAAYTK  60
   61 VVREALETFM KETIDEGLWD TLSARLDFCN LDVNDTAAFS RLGAMLDQKN RITINYFAMP 120
  121 PSTFGAICKG LGEAKLNAKP ARVVMEKPLG TSLATSQEIN DQVGEYFEEC QVYRIDHYLG 180
  181 KETVLNLLAL RFANSLFVNN WDNRTIDHVE ITVAEEVGIE GRWGYFDKAG QMRDMIQNHL 240
  241 LQILCMIAMS PPSDLSADSI RDEKVKVLKS LRRIDRSNVR EKTVRGQYTA GFAQGKKVPG 300
  301 YLEEEGANKS SNTETFVAIR VDIDNWRWAG VPFYLRTGKR LPTKCSEVVV YFKTPELNLF 360
  361 KESWQDLPQN KLTIRLQPDE GVDIQVLNKV PGLDHKHNLQ ITKLDLSYSE TFNQTHLADA 420
  421 YERLLLETMR GIQALFVRRD EVEEAWKWVD SITEAWAMDN DAPKPYQAGT WGPVASVAMI 480
  481 TRDGRSWNEF E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1qkiA
Description:	Glucose 6-phosphate dehydrogenase, N-terminal domain; Glucose 6-phosphate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glucose-6-phosphate dehydrogenase activity	5.10379236186634	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
DNA binding	1.30649176474402	bayes_pls_golite062009
nucleic acid binding	1.21797427723368	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
transcription regulator activity	1.16624046427845	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.749202992278132	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.65743456407889	bayes_pls_golite062009
transcription factor activity	0.64823933426147	bayes_pls_golite062009
hydrolase activity	0.64282074902621	bayes_pls_golite062009
transcription repressor activity	0.547377529205729	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity	0.375786741986945	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.362878028601961	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
structural molecule activity	0.34148076461528	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.225978107187737	bayes_pls_golite062009
kinase activity	0.201113035937958	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.156723490409668	bayes_pls_golite062009
glucose binding	0.13030486887358	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.126337510738706	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.111651152766906	bayes_pls_golite062009
protein kinase activity	0.0808301652371467	bayes_pls_golite062009
cation transmembrane transporter activity	0.0244314674300794	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: