YRC Public Data Repository - Protein Structure Prediction

Protein:	FUMB_ECOLI
Organism:	Escherichia coli
Length:	548 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUMB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115515532, gi... - gi\|117626408\|ref\|YP_859731.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli AP... gi\|26250935, gi\|... - gi\|26250935\|ref\|NP_756975.1\| fumarate hydratase class I, anaerobic [Escherichia coli CFT073], gi\|261... gi\|191173384, gi... - gi\|75239093\|ref\|ZP_00723073.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|227886840, gi... - gi\|227886840\|ref\|ZP_04004645.1\| fumarate hydratase [Escherichia coli 83972], gi\|227836182\|gb\|EEJ4664... gi\|91075242, gi\|... - gi\|91213668\|ref\|YP_543654.1\| fumarate hydratase class I, anaerobic [Escherichia coli UTI89], gi\|9107... gi\|218367979, gi... - gi\|218561210\|ref\|YP_002394123.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|237703709, gi... - gi\|237703709\|ref\|ZP_04534190.1\| fumarate hydratase class I [Escherichia sp. 3_2_53FAA], gi\|226901621... gi\|110644479, gi... - gi\|110644479\|ref\|YP_672209.1\| fumarate hydratase class I, anaerobic [Escherichia coli 536], gi\|11034...	845.0	[0..1]	[548..1]
gi\|191165645, gi... - gi\|75231280\|ref\|ZP_00717687.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|193063109, gi... - gi\|75259041\|ref\|ZP_00730409.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75197974, gi\|... - gi\|75197974\|ref\|ZP_00708044.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75212051, gi\|... - gi\|75212051\|ref\|ZP_00712106.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|82779274, gi\|... - gi\|82779274\|ref\|YP_405623.1\| fumarase B [Shigella dysenteriae Sd197], gi\|81243422\|gb\|ABB64132.1\| fum... gi\|188490605, gi... - gi\|75514883\|ref\|ZP_00737112.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|74314608, gi\|... - gi\|74314608\|ref\|YP_313027.1\| fumarase B [Shigella sonnei Ss046], gi\|73858085\|gb\|AAZ90792.1\| fumarase... gi\|218363443, gi... - gi\|218556674\|ref\|YP_002389588.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|218697824, gi... - gi\|218697824\|ref\|YP_002405491.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|209921611, gi... - gi\|209921611\|ref\|YP_002295695.1\| fumarase B [Escherichia coli SE11], gi\|209914870\|dbj\|BAG79944.1\| fu... gi\|75188838, gi\|... - gi\|75188838\|ref\|ZP_00702105.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	844.0	[0..1]	[548..1]
gi\|81248034, gi\|... - gi\|82546623\|ref\|YP_410570.1\| fumarase B [Shigella boydii Sb227], gi\|81248034\|gb\|ABB68742.1\| fumarase...	844.0	[0..1]	[548..1]
gi\|192958847, gi... - gi\|75238651\|ref\|ZP_00722640.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	844.0	[0..1]	[548..1]
gi\|194437240, gi... - gi\|83587247\|ref\|ZP_00925876.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|253775249, gi... - gi\|254290806\|ref\|YP_003056554.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|251787376, gi... - gi\|251787376\|ref\|YP_003001680.1\| hypothetical protein B21_03954 [Escherichia coli BL21], gi\|24237964... gi\|254164056, gi... - gi\|254164056\|ref\|YP_003047164.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli...	842.0	[0..1]	[548..1]
gi\|209750690, gi... - pir\|\|H91266 fumarase B [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952), gi\|20... gi\|13364581, gi\|... - gi\|15834358\|ref\|NP_313131.1\| fumarase B [Escherichia coli O157:H7], gi\|13364581\|dbj\|BAB38527.1\| fuma... gi\|13364581, gi\|... - gi\|15834358\|ref\|NP_313131.1\| fumarase B [Escherichia coli O157:H7 str. Sakai], gi\|13364581\|dbj\|BAB38... gi\|168760983, gi... - gi\|189368621\|gb\|EDU87037.1\| fumarate hydratase class I, anaerobic [Escherichia coli O157:H7 str. EC4... gi\|217321092, gi... - gi\|217324871\|ref\|ZP_03440955.1\| fumarate hydratase [Escherichia coli O157:H7 str. TW14588], gi\|21732...	842.0	[0..1]	[548..1]
gi\|146048 - gi\|146048\|gb\|AAA23827.1\| anaerobic class I fumarase (EC 4.2.1.2)	841.0	[0..1]	[548..1]
gi\|110807879, gi... - gi\|110807879\|ref\|YP_691399.1\| fumarate hydratase class I, anaerobic [Shigella flexneri 5 str. 8401],...	840.0	[0..1]	[548..1]
gi\|24115309, gi\|... - gi\|24115309\|ref\|NP_709819.1\| fumarase B, fumarate hydratase class I [Shigella flexneri 2a str. 301],... gi\|30042951, gi\|... - gi\|30064691\|ref\|NP_838862.1\| fumarase B, fumarate hydratase class I [Shigella flexneri 2a str. 2457T...	839.0	[0..1]	[548..1]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKPFIYQA PFPMGKDNTE YYLLTSDYVS VADFDGETIL KVEPEALTLL AQQAFHDASF  60
   61 MLRPAHQKQV AAILHDPEAS ENDKYVALQF LRNSEIAAKG VLPTCQDTGT AIIVGKKGQR 120
  121 VWTGGGDEET LSKGVYNTYI E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [142-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLRYSQNAA LDMYKEVNTG TNLPAQIDLY AVDGDEYKFL CVAKGGGSAN KTYLYQETKA  60
   61 LLTPGKLKNF LVEKMRTLGT AACPPYHIAF VIGGTSAETN LKTVKLASAH YYDELPTEGN 120
  121 EHGQAFRDVQ LEQELLEEAQ KLGLGAQFGG KYFAHDIRVI RLPRHGASCP VGMGVSCSAD 180
  181 RNIKAKINRE GIWIEKLEHN PGQY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [346-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPQELRQAGE GEAVKVDLNR PMKEILAQLS QYPVSTRLSL TGTIIVGRDI AHAKLKELID  60
   61 AGKELPQYIK DHPIYYAGPA KTPAGYPSGS LGPTTAGRMD SYVDLLQSHG GSMIMLAKGN 120
  121 RSQQVTDACH KHGGFYLGSI GGPAAVLAQQ SIKHLECVAY PELGMEAIWK IEVEDFPAFI 180
  181 LVDDKGNDFF QQIVNKQCAN CTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	2isbA
Description:	No description for 2isbA was found.

Predicted functions:

Term	Confidence	Notes
fumarate hydratase activity	4.07646355358082	bayes_pls_golite062009
catalytic activity	1.02123395223799	bayes_pls_golite062009
hydro-lyase activity	0.556078290190932	bayes_pls_golite062009
carbon-oxygen lyase activity	0.338858403016763	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: