YRC Public Data Repository - Protein Structure Prediction

Protein:	FUMB_ECOLI
Organism:	Escherichia coli
Length:	548 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUMB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115515532, gi... - gi\|117626408\|ref\|YP_859731.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli AP... gi\|26250935, gi\|... - gi\|26250935\|ref\|NP_756975.1\| fumarate hydratase class I, anaerobic [Escherichia coli CFT073], gi\|261... gi\|191173384, gi... - gi\|75239093\|ref\|ZP_00723073.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|227886840, gi... - gi\|227886840\|ref\|ZP_04004645.1\| fumarate hydratase [Escherichia coli 83972], gi\|227836182\|gb\|EEJ4664... gi\|91075242, gi\|... - gi\|91213668\|ref\|YP_543654.1\| fumarate hydratase class I, anaerobic [Escherichia coli UTI89], gi\|9107... gi\|218367979, gi... - gi\|218561210\|ref\|YP_002394123.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|237703709, gi... - gi\|237703709\|ref\|ZP_04534190.1\| fumarate hydratase class I [Escherichia sp. 3_2_53FAA], gi\|226901621... gi\|110644479, gi... - gi\|110644479\|ref\|YP_672209.1\| fumarate hydratase class I, anaerobic [Escherichia coli 536], gi\|11034...	845.0	[0..1]	[548..1]
gi\|191165645, gi... - gi\|75231280\|ref\|ZP_00717687.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|193063109, gi... - gi\|75259041\|ref\|ZP_00730409.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75197974, gi\|... - gi\|75197974\|ref\|ZP_00708044.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75212051, gi\|... - gi\|75212051\|ref\|ZP_00712106.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|82779274, gi\|... - gi\|82779274\|ref\|YP_405623.1\| fumarase B [Shigella dysenteriae Sd197], gi\|81243422\|gb\|ABB64132.1\| fum... gi\|188490605, gi... - gi\|75514883\|ref\|ZP_00737112.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|74314608, gi\|... - gi\|74314608\|ref\|YP_313027.1\| fumarase B [Shigella sonnei Ss046], gi\|73858085\|gb\|AAZ90792.1\| fumarase... gi\|218363443, gi... - gi\|218556674\|ref\|YP_002389588.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|218697824, gi... - gi\|218697824\|ref\|YP_002405491.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|209921611, gi... - gi\|209921611\|ref\|YP_002295695.1\| fumarase B [Escherichia coli SE11], gi\|209914870\|dbj\|BAG79944.1\| fu... gi\|75188838, gi\|... - gi\|75188838\|ref\|ZP_00702105.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	844.0	[0..1]	[548..1]
gi\|81248034, gi\|... - gi\|82546623\|ref\|YP_410570.1\| fumarase B [Shigella boydii Sb227], gi\|81248034\|gb\|ABB68742.1\| fumarase...	844.0	[0..1]	[548..1]
gi\|192958847, gi... - gi\|75238651\|ref\|ZP_00722640.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	844.0	[0..1]	[548..1]
gi\|194437240, gi... - gi\|83587247\|ref\|ZP_00925876.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|253775249, gi... - gi\|254290806\|ref\|YP_003056554.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|251787376, gi... - gi\|251787376\|ref\|YP_003001680.1\| hypothetical protein B21_03954 [Escherichia coli BL21], gi\|24237964... gi\|254164056, gi... - gi\|254164056\|ref\|YP_003047164.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli...	842.0	[0..1]	[548..1]
gi\|209750690, gi... - pir\|\|H91266 fumarase B [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952), gi\|20... gi\|13364581, gi\|... - gi\|15834358\|ref\|NP_313131.1\| fumarase B [Escherichia coli O157:H7], gi\|13364581\|dbj\|BAB38527.1\| fuma... gi\|13364581, gi\|... - gi\|15834358\|ref\|NP_313131.1\| fumarase B [Escherichia coli O157:H7 str. Sakai], gi\|13364581\|dbj\|BAB38... gi\|168760983, gi... - gi\|189368621\|gb\|EDU87037.1\| fumarate hydratase class I, anaerobic [Escherichia coli O157:H7 str. EC4... gi\|217321092, gi... - gi\|217324871\|ref\|ZP_03440955.1\| fumarate hydratase [Escherichia coli O157:H7 str. TW14588], gi\|21732...	842.0	[0..1]	[548..1]
gi\|146048 - gi\|146048\|gb\|AAA23827.1\| anaerobic class I fumarase (EC 4.2.1.2)	841.0	[0..1]	[548..1]
gi\|110807879, gi... - gi\|110807879\|ref\|YP_691399.1\| fumarate hydratase class I, anaerobic [Shigella flexneri 5 str. 8401],...	840.0	[0..1]	[548..1]
gi\|24115309, gi\|... - gi\|24115309\|ref\|NP_709819.1\| fumarase B, fumarate hydratase class I [Shigella flexneri 2a str. 301],... gi\|30042951, gi\|... - gi\|30064691\|ref\|NP_838862.1\| fumarase B, fumarate hydratase class I [Shigella flexneri 2a str. 2457T...	839.0	[0..1]	[548..1]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKPFIYQA PFPMGKDNTE YYLLTSDYVS VADFDGETIL KVEPEALTLL AQQAFHDASF  60
   61 MLRPAHQKQV AAILHDPEAS ENDKYVALQF LRNSEIAAKG VLPTCQDTGT AIIVGKKGQR 120
  121 VWTGGGDEET LSKGVYNTYI E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.521	0.619	fumarate hydratase activity	a.39.1	EF-hand
View	Download	0.547	0.020	fumarate hydratase activity	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.511	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.503	N/A	N/A	a.78.1	Fatty acid responsive transcription factor FadR, C-terminal domain
View	Download	0.498	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain

Predicted Domain #2

Region A:
Residues: [142-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLRYSQNAA LDMYKEVNTG TNLPAQIDLY AVDGDEYKFL CVAKGGGSAN KTYLYQETKA  60
   61 LLTPGKLKNF LVEKMRTLGT AACPPYHIAF VIGGTSAETN LKTVKLASAH YYDELPTEGN 120
  121 EHGQAFRDVQ LEQELLEEAQ KLGLGAQFGG KYFAHDIRVI RLPRHGASCP VGMGVSCSAD 180
  181 RNIKAKINRE GIWIEKLEHN PGQY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [346-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPQELRQAGE GEAVKVDLNR PMKEILAQLS QYPVSTRLSL TGTIIVGRDI AHAKLKELID  60
   61 AGKELPQYIK DHPIYYAGPA KTPAGYPSGS LGPTTAGRMD SYVDLLQSHG GSMIMLAKGN 120
  121 RSQQVTDACH KHGGFYLGSI GGPAAVLAQQ SIKHLECVAY PELGMEAIWK IEVEDFPAFI 180
  181 LVDDKGNDFF QQIVNKQCAN CTK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	2isbA
Description:	No description for 2isbA was found.

Predicted functions:

Term	Confidence	Notes
fumarate hydratase activity	4.07646355358082	bayes_pls_golite062009
catalytic activity	1.02123395223799	bayes_pls_golite062009
hydro-lyase activity	0.556078290190932	bayes_pls_golite062009
carbon-oxygen lyase activity	0.338858403016763	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: