YRC Public Data Repository - Protein Structure Prediction

Protein:	FRVR_ECOLI
Organism:	Escherichia coli
Length:	582 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRVR_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|29140366, gi\|... - gi\|29144727\|ref\|NP_808069.1\| BglB family transcriptional antiterminator [Salmonella enterica subsp. ... gi\|16505556, gi\|... - gi\|25513064\|pir\|\|AG1057 probable BglB-family transcription antiterminator STY4787 [imported] - Salmo... gi\|16763248 - gi\|16763248\|ref\|NP_458865.1\| BglB family transcriptional antiterminator [Salmonella enterica subsp. ...	288.0	[0..3]	[578..25]
gi\|167991230, gi... - gi\|205330279\|gb\|EDZ17043.1\| HTH domain protein [Salmonella enterica subsp. enterica serovar 4,[5],12... lcl\|NC_016856.1_... - [gene=STM14_5339] [protein=phosphotransferase system mannitol/fructose-specific IIA component] [prot... gi\|16767694, gi\|... - gi\|16767694\|ref\|NP_463309.1\| phosphotransferase system mannitol/fructose-specific IIA component [Sal...	285.0	[0..3]	[578..5]
gi\|197365143, gi... - gi\|197365143\|ref\|YP_002144780.1\| putative BglB-family transcriptional antiterminator [Salmonella ent... gi\|56130477, gi\|... - gi\|56416220\|ref\|YP_153295.1\| BglB family transcriptional antiterminator [Salmonella enterica subsp. ...	285.0	[0..3]	[578..25]
gi\|56908499, gi\|... - gi\|56962263\|ref\|YP_173987.1\| transcriptional antiterminator of lichenan operon [Bacillus clausii KSM...	284.0	[0..1]	[581..10]
gi\|52787767, gi\|... - gi\|52787767\|ref\|YP_093596.1\| LicR [Bacillus licheniformis ATCC 14580], gi\|52350269\|gb\|AAU42903.1\| Li...	284.0	[0..1]	[581..1]
gi\|56380395, gi\|... - gi\|56420553\|ref\|YP_147871.1\| hypothetical protein GK2018 [Geobacillus kaustophilus HTA426], gi\|56380...	282.0	[0..1]	[580..1]
LICR_BACSU - Probable licABCH operon regulator OS=Bacillus subtilis (strain 168) GN=licR PE=1 SV=1 LICR_BACSU - Probable licABCH operon regulator OS=Bacillus subtilis GN=licR PE=1 SV=1 gi\|221321064 - gi\|221321064\|ref\|ZP_03602358.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. JH... gi\|221316153 - gi\|221316153\|ref\|ZP_03597958.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. NC... gi\|221325349 - gi\|221325349\|ref\|ZP_03606643.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. SM...	281.0	[0..1]	[581..1]
gi\|89086738, gi\|... - gi\|89098493\|ref\|ZP_01171376.1\| LicR [Bacillus sp. NRRL B-14911], gi\|89086738\|gb\|EAR65856.1\| LicR [Ba...	276.0	[0..1]	[579..1]

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Predicted Domain #1

Region A:
Residues: [1-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNERQLKIV DLLEQQPRTP GELAQQTGVS GRTILRDIDY LNFTLNGKAR IFASGSAGYQ  60
   61 LEIFERRSFF QLLQKH

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	11.229148
Match:	PF08279.3
Description:	No description for PF08279.3 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [77-178]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNDDRLLALL LLNTFTPRAQ LASALNLPET WVAERLPRLK QRYERTCCLA SRPGLGHFID  60
   61 ETEEKRVILL ANLLRKDPFL IPLAGITRDN LQHLSTACDN QH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.577	a.74.1	Cyclin-like
View	Download	0.587	a.118.1	ARM repeat
View	Download	0.519	d.32.1	Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
View	Download	0.509	d.218.1	Nucleotidyltransferase
View	Download	0.520	a.74.1	Cyclin-like

Predicted Domain #3

Region A:
Residues: [179-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RWPLMQGDYL SSLILAIYAL RNQLTDEWPQ YPGDEIKQIV EHSGLFLGDN AVRTLTGLIE  60
   61 KQHQQAQVIS ADNVQGLLQR VPGIASLNII DAQLVENITG HLLRCLAAPV WIAEHRQSSM 120
  121 NNLKAAWPAA FDMSLHFITL LREQLDIPLF DSDLIGLYFA CALERHQNER QPIILLSDQN 180
  181 AIATINQLAI ERDVLNCRVI IARSLSELVA IREEIEPLLI INNSHYLLDD AVNNYITVKN 240
  241 IITAAGIEQI KHFLATAFIR QQPERFFSAP GSFHYS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.30103
Match:	1tlvA
Description:	Structure of the native and inactive LicT PRD from B. subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.56369131794526	bayes_pls_golite062009
transcription antiterminator activity	0.89593635979484	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [455-582]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVRGESWQHI TRQICAQLVA QHHITADEAQ RIIAREGEGE NLIVNRLAIP HCWSEQERRF  60
   61 RGFFITLAQP VEVNNEVINH VLIACAAADA RHELKIFSYL ASILCQHPAE IIAGLTGYEA 120
  121 FMELLHKG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.39794
Match:	1a3aA
Description:	Phosphotransferase IIa-mannitol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.919841544763066	bayes_pls_golite062009
transcription regulator activity	0.789390286938302	bayes_pls_golite062009
catalytic activity	0.547925219495929	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: