YRC Public Data Repository - Protein Structure Prediction

Protein:	DAPA_THEMA
Organism:	Thermotoga maritima
Length:	294 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DAPA_THEMA.

Description	E-value	Query Range	Subject Range
gi\|241906440, gi... - gi\|241906440\|ref\|ZP_04791022.1\| dihydrodipicolinate synthase [Desulfovibrio vulgaris RCH1], gi\|24188... DAPA_DESVV - 4-hydroxy-tetrahydrodipicolinate synthase OS=Desulfovibrio vulgaris subsp. vulgaris (strain DP4) GN=... DAPA_DESVH - 4-hydroxy-tetrahydrodipicolinate synthase OS=Desulfovibrio vulgaris (strain Hildenborough / ATCC 295...	375.0	[0..2]	[294..3]
DAPA_METJA - Dihydrodipicolinate synthase OS=Methanocaldococcus jannaschii GN=dapA PE=1 SV=1 DAPA_METJA - 4-hydroxy-tetrahydrodipicolinate synthase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM ...	375.0	[0..1]	[294..1]
DAPA_AQUAE - Dihydrodipicolinate synthase OS=Aquifex aeolicus GN=dapA PE=1 SV=1 DAPA_AQUAE - 4-hydroxy-tetrahydrodipicolinate synthase OS=Aquifex aeolicus (strain VF5) GN=dapA PE=1 SV=1	374.0	[0..1]	[293..1]
DAPA_GEOUR - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter uraniireducens (strain Rf4) GN=dapA PE=3 SV=1	374.0	[0..1]	[294..1]
gi\|37927075, gi\|... - gi\|37927076\|pdb\|1O5K\|B Chain B, Crystal Structure Of Dihydrodipicolinate Synthase (Tm1521) From Ther...	373.0	[0..1]	[294..13]
DAPA_BARBK - 4-hydroxy-tetrahydrodipicolinate synthase OS=Bartonella bacilliformis (strain ATCC 35685 / KC583) GN...	371.0	[0..1]	[294..1]
DAPA_GEOMG - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter metallireducens (strain GS-15 / ATCC 53774 / ...	370.0	[0..1]	[294..1]
gi\|91202476 - gi\|91202476\|emb\|CAJ72115.1\| strongly similar to dihydropicolinate synthase (DHDPS) [Candidatus Kuene...	369.0	[0..1]	[294..1]
DAPA_GEOSL - Dihydrodipicolinate synthase OS=Geobacter sulfurreducens GN=dapA PE=3 SV=1 DAPA_GEOSL - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127...	368.0	[0..1]	[294..1]
DAPA_GEODF - 4-hydroxy-tetrahydrodipicolinate synthase OS=Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-...	362.0	[0..1]	[294..1]

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Predicted Domain #1

Region A:
Residues: [1-294]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRGVGTAIV TPFKNGELDL ESYERLVRYQ LENGVNALIV LGTTGESPTV NEDEREKLVS  60
   61 RTLEIVDGKI PVIVGAGTNS TEKTLKLVKQ AEKLGANGVL VVTPYYNKPT QEGLYQHYKY 120
  121 ISERTDLGIV VYNVPGRTGV NVLPETAARI AADLKNVVGI KEANPDIDQI DRTVSLTKQA 180
  181 RSDFMVWSGN DDRTFYLLCA GGDGVISVVS NVAPKQMVEL CAEYFSGNLE KSREVHRKLR 240
  241 PLMKALFVET NPIPVKAALN LMGFIENELR LPLVPASEKT VELLRNVLKE SGLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	105.0
Match:	1o5kA
Description:	Crystal structure of Dihydrodipicolinate synthase (TM1521) from Thermotoga maritima at 1.80 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.67031204377352	bayes_pls_golite062009
3-deoxy-7-phosphoheptulonate synthase activity	2.02591266233154	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	1.7625405035454	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	1.72893315846141	bayes_pls_golite062009
transaldolase activity	1.38790063456575	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
aldehyde-lyase activity	0.351872954170322	bayes_pls_golite062009
binding	0.038419829456847	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: