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View Structure Prediction Details

Protein: CYTC_RAT
Organism: Rattus norvegicus
Length: 127 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYTC_RAT.

Description E-value Query
Range
Subject
Range
gi|109093125 - gi|109093125|ref|XP_001097284.1| PREDICTED: cystatin SA [Macaca mulatta]
157.0 [0..8] [127..22]
gi|58081 - gi|58081|emb|CAA31253.1| ompA - cystatin C fusion preprotein (AA -21 to 120) [synthetic construct]
152.0 [0..3] [127..17]
gi|226712 - gi|226712|prf||1604194A cystatin C
152.0 [0..1] [127..1]
CYTC_SAISC - Cystatin-C OS=Saimiri sciureus GN=CST3 PE=2 SV=1
151.0 [0..5] [127..24]
CST4 - cystatin S
151.0 [0..8] [127..22]
gi|55651363, gi|... - gi|55651363|ref|XP_514553.1| PREDICTED: similar to cystain S isoform 2 [Pan troglodytes], gi|1146812...
151.0 [0..8] [127..22]

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Predicted Domain #1
Region A:
Residues: [1-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLAVAWAGTS RPPPRLLGAP QEADASEEGV QRALDFAVSE YNKGSNDAYH SRAIQVVRAR  60
   61 KQLVAGINYY LDVEMGRTTC TKSQTNLTNC PFHDQPHLMR KALCSFQIYS VPWKGTHTLT 120
  121 KSSCKNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.154902
Match: 1g96A
Description: Cystatin C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase inhibitor activity 4.09256652564756 bayes_pls_golite062009
endopeptidase inhibitor activity 4.06934751275178 bayes_pls_golite062009
metalloendopeptidase inhibitor activity 3.91155159929014 bayes_pls_golite062009
metalloenzyme regulator activity 3.91155159929014 bayes_pls_golite062009
metalloenzyme inhibitor activity 3.91155159929014 bayes_pls_golite062009
protease binding 3.73826839062329 bayes_pls_golite062009
enzyme inhibitor activity 3.46240889348325 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 2.23436900482885 bayes_pls_golite062009
binding 1.98021211698364 bayes_pls_golite062009
protein binding 1.87374230443113 bayes_pls_golite062009
enzyme binding 1.6342022584305 bayes_pls_golite062009
beta-amyloid binding 0.57867775643241 bayes_pls_golite062009
enzyme regulator activity 0.479748849334581 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle