YRC Public Data Repository - Protein Structure Prediction

Protein:	CUSC_ECOLI
Organism:	Escherichia coli
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUSC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|71488678, gi\|... - gi\|71545481\|ref\|ZP_00666412.1\| RND efflux system, outer membrane lipoprotein, NodT [Syntrophobacter ...	353.0	[0..4]	[457..213]
gi\|85858611, gi\|... - gi\|85858611\|ref\|YP_460813.1\| type I secretion outer membrane protein [Syntrophus aciditrophicus SB],...	348.0	[0..2]	[457..38]
gi\|23471294, gi\|... - gi\|66047236\|ref\|YP_237077.1\| RND efflux system, outer membrane lipoprotein, NodT [Pseudomonas syring...	346.0	[0..1]	[457..1]
gi\|71736997, gi\|... - gi\|71736997\|ref\|YP_276145.1\| NodT family outer membrane efflux lipoprotein [Pseudomonas syringae pv....	346.0	[0..1]	[457..1]
gi\|28854693, gi\|... - gi\|28871442\|ref\|NP_794061.1\| outer membrane efflux protein [Pseudomonas syringae pv. tomato str. DC3... tr\|Q87X83\|Q87X83... - Outer membrane efflux protein OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=PSPTO_4305 PE=4 ...	342.0	[0..1]	[457..1]
gi\|94731686, gi\|... - gi\|94987437\|ref\|YP_595370.1\| outer membrane efflux protein [Lawsonia intracellularis PHE/MN1-00], gi...	340.0	[0..2]	[456..1]
gi\|71741812, gi\|... - gi\|71837530\|ref\|ZP_00677294.1\| RND efflux system, outer membrane lipoprotein, NodT [Pelobacter propi...	336.0	[0..1]	[457..6]
gi\|83593387, gi\|... - gi\|83593387\|ref\|YP_427139.1\| RND efflux system, outer membrane lipoprotein, NodT [Rhodospirillum rub...	335.0	[0..1]	[457..13]
gi\|157412124 - gi\|157412124\|ref\|YP_001481465.1\| copper/silver efflux system outer membrane protein CusC [Escherichi... gi\|218697184, gi... - gi\|218697184\|ref\|YP_002404851.1\| copper/silver efflux system outer membrane protein CusC [Escherichi... gi\|99867149 - gi\|99867149\|gb\|ABF67794.1\| SilC [Escherichia coli APEC O1]	334.0	[0..1]	[457..102]
gi\|67981567, gi\|... - gi\|95930203\|ref\|ZP_01312941.1\| Hydrophobe/amphiphile efflux-1 HAE1 [Desulfuromonas acetoxidans DSM 6...	333.0	[0..5]	[457..1044]

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Predicted Domain #1

Region A:
Residues: [1-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPCKLLPFC VALALTGCSL APDYQRPAMP VPQQFSLSQN GLVNAADNYQ NAGWRTFFVD  60
   61 NQVKTLISEA LVNNRDLRMA TLKVQEARAQ YRLTDADRYP QLNGEGSGSW SGNLKGNTAT 120
  121 TREFSTGLNA SFDLDFFGRL KNMSEAERQN YLATEEAQRA VHILLVSNVA QSYFNQQLAY 180
  181 AQLQIAEETL RNYQQSYAFV EKQLLTGSSN VLALEQARGV IESTRSDIAK RQGELAQANN 240
  241 ALQLLLGSYG KLPQAQTVNS DSLQSVKLPA GLSSQILLQR PDIMEAEHAL MAANANIGAA 300
  301 RAAFFPSISL TSGISTASSD LSSLFNASSG MWNFIPKIEI PIFNAGRNQA NLDIAEIRQQ 360
  361 QSVVNYEQKI QNAFKEVADA LALRQSLNDQ ISAQQRYLAS LQITLQRARA LYQHGAVSYL 420
  421 EVLDAERSLF ATRQTLLDLN YARQVNEISL YTALGGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	82.30103
Match:	1wp1A
Description:	Crystal structure of the drug-discharge outer membrane protein, OprM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
drug transmembrane transporter activity	4.81710579303325	bayes_pls_golite062009
	4.35844117790122	bayes_pls_golite062009
	4.29225678658868	bayes_pls_golite062009
transporter activity	4.2806100513341	bayes_pls_golite062009
transmembrane transporter activity	2.91628575119399	bayes_pls_golite062009
porin activity	0.960340223825989	bayes_pls_golite062009
binding	0.666039242029224	bayes_pls_golite062009
channel activity	0.517545908208242	bayes_pls_golite062009
passive transmembrane transporter activity	0.517545908208242	bayes_pls_golite062009
efflux transmembrane transporter activity	0.381147202210091	bayes_pls_golite062009
protein binding	0.0827883348198969	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: