YRC Public Data Repository - Protein Structure Prediction

Protein:	CLPA_ECOLI
Organism:	Escherichia coli
Length:	758 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLPA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|53804153, gi\|... - gi\|53804153\|ref\|YP_114227.1\| ATP-dependent Clp protease, ATP-binding subunit ClpA [Methylococcus cap...	599.0	[0..1]	[752..1]
gi\|52695362, gi\|... - gi\|52695362\|pdb\|1R6B\|X Chain X, High Resolution Crystal Structure Of Clpa, gi\|24158791\|pdb\|1KSF\|X Ch...	597.0	[0..1]	[758..1]
gi\|110342675, gi... - gi\|110641083\|ref\|YP_668813.1\| ATP-dependent Clp protease ATP-binding subunit [Escherichia coli 536],... gi\|190907674, gi... - gi\|75240960\|ref\|ZP_00724849.1\| COG0542: ATPases with chaperone activity, ATP-binding subunit [Escher...	595.0	[0..1]	[758..1]
gi\|117623060, gi... - gi\|117623060\|ref\|YP_851973.1\| ATP-dependent Clp protease ATP-binding subunit [Escherichia coli APEC ...	595.0	[0..1]	[758..3]
gi\|237707136, gi... - gi\|237707136\|ref\|ZP_04537617.1\| ATP-dependent clp protease ATP-binding subunit clpA [Escherichia sp.... gi\|26246908, gi\|... - gi\|26246908\|ref\|NP_752948.1\| ATP-dependent clp protease ATP-binding subunit clpA [Escherichia coli C... gi\|91071493, gi\|... - gi\|91209919\|ref\|YP_539905.1\| ATP-dependent clp protease ATP-binding subunit clpA [Escherichia coli U...	595.0	[0..1]	[758..6]
gi\|81244780, gi\|... - gi\|82543369\|ref\|YP_407316.1\| ATP-dependent Clp protease ATP-binding subunit [Shigella boydii Sb227],...	594.0	[0..1]	[758..1]
gi\|30040615, gi\|... - gi\|30062370\|ref\|NP_836541.1\| ATP-dependent Clp protease ATP-binding subunit [Shigella flexneri 2a st...	594.0	[0..1]	[758..1]
gi\|110614432, gi... - gi\|110804884\|ref\|YP_688404.1\| ATP-dependent Clp protease ATP-binding subunit [Shigella flexneri 5 st...	594.0	[0..1]	[758..1]
gi\|75511050, gi\|... - gi\|75511050\|ref\|ZP_00733788.1\| COG0542: ATPases with chaperone activity, ATP-binding subunit [Escher...	594.0	[0..1]	[758..1]
gi\|56414002, gi\|... - gi\|56414002\|ref\|YP_151077.1\| ATP-dependent Clp protease ATP-binding subunit [Salmonella enterica sub... gi\|206708143, gi... - gi\|207856340\|ref\|YP_002242991.1\| ATP-dependent Clp protease ATP-binding subunit [Salmonella enterica... gi\|204929911, gi... - gi\|204929911\|ref\|ZP_03220932.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ente... gi\|199603131, gi... - gi\|200390686\|ref\|ZP_03217297.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ente... gi\|198245341, gi... - gi\|198245341\|ref\|YP_002214873.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ent... gi\|197094402, gi... - gi\|197362925\|ref\|YP_002142562.1\| ATP-dependent Clp protease ATP-binding subunit [Salmonella enterica... gi\|194736159, gi... - gi\|194736159\|ref\|YP_002114002.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ent... gi\|194471361, gi... - gi\|194471361\|ref\|ZP_03077345.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ente... gi\|194404161, gi... - gi\|194445498\|ref\|YP_002040146.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella ent... gi\|205343166, gi... - gi\|205343166\|gb\|EDZ29930.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella enterica... gi\|195631031, gi... - gi\|195631031\|gb\|EDX49617.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella enterica... gi\|168263569, gi... - gi\|205347800\|gb\|EDZ34431.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella enterica... gi\|168236856, gi... - gi\|197290116\|gb\|EDY29473.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella enterica... gi\|205334776, gi... - gi\|205334776\|gb\|EDZ21540.1\| ATP-dependent Clp protease ATP-binding subunit ClpA [Salmonella enterica... gi\|161614824, gi... - gi\|161614824\|ref\|YP_001588789.1\| ATP-dependent Clp protease ATP-binding subunit [Salmonella enterica...	594.0	[0..1]	[758..1]

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Predicted Domain #1

Region A:
Residues: [1-758]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNQELELSL NMAFARAREH RHEFMTVEHL LLALLSNPSA REALEACSVD LVALRQELEA  60
   61 FIEQTTPVLP ASEEERDTQP TLSFQRVLQR AVFHVQSSGR NEVTGANVLV AIFSEQESQA 120
  121 AYLLRKHEVS RLDVVNFISH GTRKDEPTQS SDPGSQPNSE EQAGGEERME NFTTNLNQLA 180
  181 RVGGIDPLIG REKELERAIQ VLCRRRKNNP LLVGESGVGK TAIAEGLAWR IVQGDVPEVM 240
  241 ADCTIYSLDI GSLLAGTKYR GDFEKRFKAL LKQLEQDTNS ILFIDEIHTI IGAGAASGGQ 300
  301 VDAANLIKPL LSSGKIRVIG STTYQEFSNI FEKDRALARR FQKIDITEPS IEETVQIING 360
  361 LKPKYEAHHD VRYTAKAVRA AVELAVKYIN DRHLPDKAID VIDEAGARAR LMPVSKRKKT 420
  421 VNVADIESVV ARIARIPEKS VSQSDRDTLK NLGDRLKMLV FGQDKAIEAL TEAIKMARAG 480
  481 LGHEHKPVGS FLFAGPTGVG KTEVTVQLSK ALGIELLRFD MSEYMERHTV SRLIGAPPGY 540
  541 VGFDQGGLLT DAVIKHPHAV LLLDEIEKAH PDVFNILLQV MDNGTLTDNN GRKADFRNVV 600
  601 LVMTTNAGVR ETERKSIGLI HQDNSTDAME EIKKIFTPEF RNRLDNIIWF DHLSTDVIHQ 660
  661 VVDKFIVELQ VQLDQKGVSL EVSQEARNWL AEKGYDRAMG ARPMARVIQD NLKKPLANEL 720
  721 LFGSLVDGGQ VTVALDKEKN ELTYGFQSAQ KHKAEAAH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	1ksfX
Description:	N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.55157966585974	bayes_pls_golite062009
binding	1.41264401383678	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
purine nucleotide binding	0.569910969126728	bayes_pls_golite062009
purine ribonucleotide binding	0.568840867400671	bayes_pls_golite062009
ribonucleotide binding	0.568779924702229	bayes_pls_golite062009
nucleotide binding	0.564275755355315	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.546796591575762	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.543610140926125	bayes_pls_golite062009
pyrophosphatase activity	0.540750418412449	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.517457589081898	bayes_pls_golite062009
ATP binding	0.1860481660648	bayes_pls_golite062009
adenyl ribonucleotide binding	0.152859582615242	bayes_pls_golite062009
adenyl nucleotide binding	0.138615225841109	bayes_pls_golite062009
nucleic acid binding	0.030747546048349	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: