YRC Public Data Repository - Protein Structure Prediction

Protein:	CBL_ECOLI
Organism:	Escherichia coli
Length:	316 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBL_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|89209186, gi\|... - gi\|89209186\|ref\|ZP_01187638.1\| regulatory protein, LysR:LysR, substrate-binding [Bacillus weihenstep...	257.0	[0..1]	[292..9]
gi\|228901018, gi... - gi\|228901018\|ref\|ZP_04065229.1\| Transcriptional regulator, LysR [Bacillus thuringiensis IBL 4222], g... gi\|218541706, gi... - gi\|218897372\|ref\|YP_002445783.1\| transcriptional regulator, LysR family [Bacillus cereus G9842], gi\|... gi\|228965395, gi... - gi\|228965395\|ref\|ZP_04126485.1\| Transcriptional regulator, LysR [Bacillus thuringiensis serovar sott... gi\|74491626, gi\|... - gi\|75760891\|ref\|ZP_00740903.1\| Transcriptional regulators, LysR family [Bacillus thuringiensis serov...	255.0	[0..1]	[292..4]
gi\|229127805, gi... - gi\|229127805\|ref\|ZP_04256791.1\| Transcriptional regulator, LysR [Bacillus cereus BDRD-Cer4], gi\|2286... gi\|30020498, gi\|... - gi\|30020498\|ref\|NP_832129.1\| LysR family transcriptional regulator [Bacillus cereus ATCC 14579], gi\|...	254.0	[0..1]	[292..4]
gi\|237705300, gi... - gi\|237705300\|ref\|ZP_04535781.1\| transcriptional regulator CysB [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|238860946, gi... - gi\|238900508\|ref\|YP_002926304.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-bindi... gi\|242377053, gi... - gi\|251784780\|ref\|YP_002999084.1\| hypothetical protein B21_01261 [Escherichia coli BL21], gi\|24237705... gi\|253324772, gi... - gi\|254288163\|ref\|YP_003053911.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-bindi... gi\|253973256, gi... - gi\|254161355\|ref\|YP_003044463.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-bindi... gi\|254792863, gi... - gi\|254792863\|ref\|YP_003077700.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-bindi... gi\|187731082, gi... - gi\|187731082\|ref\|YP_001880106.1\| HTH-type transcriptional regulator CysB [Shigella boydii CDC 3083-9... gi\|117623535, gi... - gi\|117623535\|ref\|YP_852448.1\| transcriptional regulator CysB [Escherichia coli APEC O1], gi\|11551265... gi\|169888787, gi... - gi\|170080952\|ref\|YP_001730272.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-bindi... gi\|124500578, gi... - gi\|124528346\|ref\|ZP_01699656.1\| transcriptional regulator, LysR family [Escherichia coli B], gi\|1245... gi\|190903333, gi... - gi\|191166684\|ref\|ZP_03028512.1\| HTH-type transcriptional regulator CysB [Escherichia coli B7A], gi\|1... gi\|188496048, gi... - gi\|188496048\|ref\|ZP_03003318.1\| HTH-type transcriptional regulator CysB [Escherichia coli 53638], gi... CYSB_ECOLI - HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator) - Escherichia coli gi\|192956708, gi... - gi\|193069955\|ref\|ZP_03050903.1\| HTH-type transcriptional regulator CysB [Escherichia coli E110019], ... gi\|193062611, gi... - gi\|193062611\|ref\|ZP_03043705.1\| HTH-type transcriptional regulator CysB [Escherichia coli E22], gi\|1... gi\|194416419, gi... - gi\|194435339\|ref\|ZP_03067546.1\| HTH-type transcriptional regulator CysB [Shigella dysenteriae 1012],... gi\|194415824, gi... - gi\|194425769\|ref\|ZP_03058325.1\| HTH-type transcriptional regulator CysB [Escherichia coli B171], gi\|... gi\|110641508, gi... - gi\|110641508\|ref\|YP_669238.1\| transcriptional regulator CysB [Escherichia coli 536], gi\|110343100\|gb... gi\|168763575, gi... - gi\|189366226\|gb\|EDU84642.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 str. E... gi\|168751167, gi... - gi\|188014764\|gb\|EDU52886.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 str. E... gi\|187769279, gi... - gi\|187769279\|gb\|EDU33123.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 str. E... gi\|89108121, gi\|... - gi\|89108121\|ref\|AP_001901.1\| DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding [... gi\|189359957, gi... - gi\|189359957\|gb\|EDU78376.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 str. E... gi\|91072141, gi\|... - gi\|91210567\|ref\|YP_540553.1\| transcriptional regulator CysB [Escherichia coli UTI89], gi\|91072141\|gb... gi\|169755289, gi... - gi\|170020361\|ref\|YP_001725315.1\| transcriptional regulator CysB [Escherichia coli ATCC 8739], gi\|169... gi\|13361312, gi\|... - gi\|15831101\|ref\|NP_309874.1\| transcriptional regulator CysB [Escherichia coli O157:H7 str. Sakai], g... gi\|168783780, gi... - gi\|188998962\|gb\|EDU67948.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 str. E... gi\|81245680, gi\|... - gi\|82544269\|ref\|YP_408216.1\| transcriptional regulator CysB [Shigella boydii Sb227], gi\|81245680\|gb\|... gi\|191170907, gi... - gi\|75242074\|ref\|ZP_00725868.1\| COG0583: Transcriptional regulator [Escherichia coli F11], gi\|1911709... EG10184 - N-acetylserine-responsive cysteine regulon transcriptional activator; autorepressor / Transcriptiona... CYSB_ECOL6 - HTH-type transcriptional regulator CysB OS=Escherichia coli O6 GN=cysB PE=3 SV=1 CYSB_ECOL6 - HTH-type transcriptional regulator CysB OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPE... CYSB_ECO57 - HTH-type transcriptional regulator CysB OS=Escherichia coli O157:H7 GN=cysB PE=3 SV=1 EG10184 - N-acetylserine-responsive cysteine regulon transcriptional activator; autorepressor / Transcriptiona... gi\|15801904, gi\|... - gi\|15801904\|ref\|NP_287924.1\| transcriptional regulator CysB [Escherichia coli O157:H7 EDL933], gi\|12... gi\|157066460, gi... - gi\|157160780\|ref\|YP_001458098.1\| transcriptional regulator CysB [Escherichia coli HS], gi\|157066460\|... gi\|218360596, gi... - gi\|218553828\|ref\|YP_002386741.1\| transcriptional regulator CysB [Escherichia coli IAI1], gi\|21836059... gi\|217317662, gi... - gi\|217329223\|ref\|ZP_03445303.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 st... gi\|218689266, gi... - gi\|218689266\|ref\|YP_002397478.1\| transcriptional regulator CysB [Escherichia coli ED1a], gi\|21842683... gi\|218558263, gi... - gi\|218558263\|ref\|YP_002391176.1\| transcriptional regulator CysB [Escherichia coli S88], gi\|218365032... gi\|218431896, gi... - gi\|218704799\|ref\|YP_002412318.1\| transcriptional regulator CysB [Escherichia coli UMN026], gi\|218431... gi\|218351579, gi... - gi\|218694847\|ref\|YP_002402514.1\| transcriptional regulator CysB [Escherichia coli 55989], gi\|2183515... gi\|157157588, gi... - gi\|157157588\|ref\|YP_001462572.1\| transcriptional regulator CysB [Escherichia coli E24377A], gi\|15707... gi\|195939211 - gi\|195939211\|ref\|ZP_03084593.1\| transcriptional regulator CysB [Escherichia coli O157:H7 str. EC4024... gi\|194424053, gi... - gi\|194437070\|ref\|ZP_03069169.1\| HTH-type transcriptional regulator CysB [Escherichia coli 101-1], gi... gi\|208816350, gi... - gi\|208816350\|ref\|ZP_03257529.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 st... gi\|208724585, gi... - gi\|208811079\|ref\|ZP_03252912.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 st... gi\|209399190, gi... - gi\|209399190\|ref\|YP_002270329.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 s... gi\|208819393, gi... - gi\|208819393\|ref\|ZP_03259713.1\| HTH-type transcriptional regulator CysB [Escherichia coli O157:H7 st... gi\|215486570, gi... - gi\|215486570\|ref\|YP_002329001.1\| transcriptional regulator CysB [Escherichia coli O127:H6 str. E2348... gi\|209918514, gi... - gi\|209918514\|ref\|YP_002292598.1\| transcriptional regulator CysB [Escherichia coli SE11], gi\|20991177...	253.0	[0..1]	[314..1]
gi\|24112672, gi\|... - gi\|24112672\|ref\|NP_707182.1\| transcriptional regulator CysB [Shigella flexneri 2a str. 301], gi\|2405... gi\|30041045, gi\|... - gi\|30062797\|ref\|NP_836968.1\| transcriptional regulator CysB [Shigella flexneri 2a str. 2457T], gi\|30... gi\|110805276, gi... - gi\|110805276\|ref\|YP_688796.1\| transcriptional regulator CysB [Shigella flexneri 5 str. 8401], gi\|110...	253.0	[0..1]	[314..1]
gi\|47570132, gi\|... - gi\|47570132\|ref\|ZP_00240789.1\| transcription regulator LysR family VC1617, putative [Bacillus cereus...	252.0	[0..1]	[297..4]
gi\|81240782, gi\|... - gi\|82776634\|ref\|YP_402983.1\| transcriptional regulator CysB [Shigella dysenteriae Sd197], gi\|8124078...	252.0	[0..1]	[314..1]
gi\|74312356, gi\|... - gi\|74312356\|ref\|YP_310775.1\| transcriptional regulator CysB [Shigella sonnei Ss046], gi\|73855833\|gb\|...	252.0	[0..1]	[314..1]
gi\|238894332, gi... - gi\|238894332\|ref\|YP_002919066.1\| transcriptional regulator for cysteine regulon [Klebsiella pneumoni... gi\|628813 - gi\|628813\|pir\|\|S43835 regulatory protein cysB - Klebsiella sp. (ATCC 15380) CYSB_KLEAE - (P45600) HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator) CYSB_KLEPN - HTH-type transcriptional regulator CysB OS=Klebsiella pneumoniae GN=cysB PE=1 SV=2 gi\|152969825, gi... - gi\|152969825\|ref\|YP_001334934.1\| transcriptional regulator CysB [Klebsiella pneumoniae subsp. pneumo...	252.0	[0..1]	[314..1]
gi\|511012 - gi\|511012\|emb\|CAA55380.1\| CYSB protein [Klebsiella aerogenes]	251.0	[0..1]	[314..1]

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Predicted Domain #1

Region A:
Residues: [1-90]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFQQLKIIR EAARQDYNLT EVANMLFTSQ SGVSRHIREL EDELGIEIFV RRGKRLLGMT  60
   61 EPGKALLVIA ERILNEASNV RRLADLFTND

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.97
Match:	1al3A
Description:	COFACTOR BINDING FRAGMENT OF CYSB FROM KLEBSIELLA AEROGENES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	1.94589732800347	bayes_pls_golite062009
binding	1.22974981386189	bayes_pls_golite062009
DNA binding	1.17819490552432	bayes_pls_golite062009
transcription factor activity	1.16426836378268	bayes_pls_golite062009
catalytic activity	1.01902493577147	bayes_pls_golite062009
nucleic acid binding	0.953794281969348	bayes_pls_golite062009
protein binding	0.138875703976769	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [91-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSGVLTIATT HTQARYSLPE VIKAFRELFP EVRLELIQGT PQEIATLLQN GEADIGIASE  60
   61 RLSNDPQLVA FPWFRWHHSL LVPHDHPLTQ ISPLTLESIA KWPLITYRQG ITGRSRIDDA 120
  121 FARKGLLADI VLSAQDSDVI KTYVALGLGI GLVAEQSSGE QEEENLIRLD TRHLFDANTV 180
  181 WLGLKRGQLQ RNYVWRFLEL CNAGLSVEDI KRQVMESSEE EIDYQI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.30103
Match:	2fyiA
Description:	Crystal Structure of the Cofactor-Binding Domain of the Cbl Transcriptional Regulator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.06846313752146	bayes_pls_golite062009
transcription factor activity	1.54776226622667	bayes_pls_golite062009
DNA binding	1.53867658911479	bayes_pls_golite062009
nucleic acid binding	1.45471488657915	bayes_pls_golite062009
binding	1.29220115989941	bayes_pls_golite062009
catalytic activity	1.04475291968158	bayes_pls_golite062009
protein binding	0.0639574144110515	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: