YRC Public Data Repository - Protein Structure Prediction

Protein:	ACRB_ECOLI
Organism:	Escherichia coli
Length:	1049 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACRB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82775807, gi\|... - gi\|82775807\|ref\|YP_402154.1\| acridine efflux pump [Shigella dysenteriae Sd197], gi\|81239955\|gb\|ABB60...	862.0	[0..1]	[1049..1]
gi\|110614037, gi... - gi\|110804489\|ref\|YP_688009.1\| acriflavin resistance protein [Shigella flexneri 5 str. 8401], gi\|1106...	862.0	[0..1]	[1049..1]
gi\|13539232 - gi\|13539232\|emb\|CAC35725.1\| AcrB protein [Enterobacter aerogenes]	862.0	[0..1]	[1049..1]
gi\|148807120, gi... - gi\|148807120\|gb\|ABR13271.1\| AcrB [Enterobacter cloacae], gi\|112182849\|emb\|CAL18626.1\| AcrB protein [...	862.0	[0..1]	[1049..1]
gi\|26246475, gi\|... - gi\|26246475\|ref\|NP_752514.1\| acriflavin resistance protein B [Escherichia coli CFT073], gi\|26106873\|... gi\|227838612, gi... - gi\|227884526\|ref\|ZP_04002331.1\| acridine efflux pump [Escherichia coli 83972], gi\|227838612\|gb\|EEJ49... gi\|218425889, gi... - gi\|218688325\|ref\|YP_002396537.1\| multidrug efflux system protein [Escherichia coli ED1a], gi\|2184258... gi\|218703745, gi... - gi\|218703745\|ref\|YP_002411264.1\| multidrug efflux system protein [Escherichia coli UMN026], gi\|21843... gi\|215263614, gi... - gi\|215485542\|ref\|YP_002327973.1\| multidrug efflux system protein [Escherichia coli O127:H6 str. E234...	862.0	[0..1]	[1049..1]
gi\|187427149, gi... - gi\|75177594\|ref\|ZP_00697675.1\| COG0841: Cation/multidrug efflux pump [Shigella boydii BS512], gi\|187...	861.0	[0..1]	[1049..1]
gi\|206707757, gi... - gi\|207855954\|ref\|YP_002242605.1\| acriflavin resistance protein B [Salmonella enterica subsp. enteric... gi\|197940656, gi... - gi\|198246140\|ref\|YP_002214428.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteri... gi\|199602560, gi... - gi\|200390115\|ref\|ZP_03216726.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteric... gi\|197213307, gi... - gi\|197249604\|ref\|YP_002145456.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteri... gi\|197264579, gi... - gi\|197264579\|ref\|ZP_03164653.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteric... gi\|194470936, gi... - gi\|194470936\|ref\|ZP_03076920.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteric... gi\|194736378, gi... - gi\|194736378\|ref\|YP_002113506.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteri... gi\|194405349, gi... - gi\|194446686\|ref\|YP_002039718.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteri... gi\|194407720, gi... - gi\|194449416\|ref\|YP_002044509.1\| acriflavine resistance protein B [Salmonella enterica subsp. enteri... gi\|168465570, gi... - gi\|195631676\|gb\|EDX50196.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|238911395 - gi\|238911395\|ref\|ZP_04655232.1\| acriflavin resistance protein B [Salmonella enterica subsp. enterica... gi\|205343984, gi... - gi\|205343984\|gb\|EDZ30748.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|197289507, gi... - gi\|197289507\|gb\|EDY28870.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|205340025, gi... - gi\|205340025\|gb\|EDZ26789.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|167990460, gi... - gi\|205330914\|gb\|EDZ17678.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|168231464, gi... - gi\|205334152\|gb\|EDZ20916.1\| acriflavine resistance protein B [Salmonella enterica subsp. enterica se... gi\|161615329, gi... - gi\|161615329\|ref\|YP_001589294.1\| hypothetical protein SPAB_03099 [Salmonella enterica subsp. enteric... lcl\|NC_016856.1_... - [gene=acrB] [protein=acridine efflux pump] [protein_id=YP_005236172.1] [location=complement(529941..... gi\|16418982, gi\|... - gi\|16763855\|ref\|NP_459470.1\| acridine efflux pump [Salmonella typhimurium LT2], gi\|16418982\|gb\|AAL19...	861.0	[0..1]	[1048..1]
gi\|62126720, gi\|... - gi\|62179087\|ref\|YP_215504.1\| acridine efflux system protein [Salmonella enterica subsp. enterica ser...	861.0	[0..1]	[1048..1]
gi\|29138405, gi\|... - gi\|29142773\|ref\|NP_806115.1\| acriflavin resistance protein B [Salmonella enterica subsp. enterica se... gi\|16759455 - gi\|16759455\|ref\|NP_455072.1\| acriflavin resistance protein B [Salmonella enterica subsp. enterica se... gi\|213162899 - gi\|213162899\|ref\|ZP_03348609.1\| acriflavin resistance protein B [Salmonella enterica subsp. enterica... gi\|25318730, gi\|... - gi\|25318730\|pir\|\|AF0561 acriflavin resistance protein B [imported] - Salmonella enterica subsp. ente...	861.0	[0..1]	[1048..1]
gi\|30061962, gi\|... - gi\|30061962\|ref\|NP_836133.1\| acriflavine resistance protein [Shigella flexneri 2a str. 2457T], gi\|30...	861.0	[0..1]	[1049..1]

Back

Predicted Domain #1

Region A:
Residues: [1-1049]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNFFIDRPI FAWVIAIIIM LAGGLAILKL PVAQYPTIAP PAVTISASYP GADAKTVQDT  60
   61 VTQVIEQNMN GIDNLMYMSS NSDSTGTVQI TLTFESGTDA DIAQVQVQNK LQLAMPLLPQ 120
  121 EVQQQGVSVE KSSSSFLMVV GVINTDGTMT QEDISDYVAA NMKDAISRTS GVGDVQLFGS 180
  181 QYAMRIWMNP NELNKFQLTP VDVITAIKAQ NAQVAAGQLG GTPPVKGQQL NASIIAQTRL 240
  241 TSTEEFGKIL LKVNQDGSRV LLRDVAKIEL GGENYDIIAE FNGQPASGLG IKLATGANAL 300
  301 DTAAAIRAEL AKMEPFFPSG LKIVYPYDTT PFVKISIHEV VKTLVEAIIL VFLVMYLFLQ 360
  361 NFRATLIPTI AVPVVLLGTF AVLAAFGFSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM 420
  421 AEEGLPPKEA TRKSMGQIQG ALVGIAMVLS AVFVPMAFFG GSTGAIYRQF SITIVSAMAL 480
  481 SVLVALILTP ALCATMLKPI AKGDHGEGKK GFFGWFNRMF EKSTHHYTDS VGGILRSTGR 540
  541 YLVLYLIIVV GMAYLFVRLP SSFLPDEDQG VFMTMVQLPA GATQERTQKV LNEVTHYYLT 600
  601 KEKNNVESVF AVNGFGFAGR GQNTGIAFVS LKDWADRPGE ENKVEAITMR ATRAFSQIKD 660
  661 AMVFAFNLPA IVELGTATGF DFELIDQAGL GHEKLTQARN QLLAEAAKHP DMLTSVRPNG 720
  721 LEDTPQFKID IDQEKAQALG VSINDINTTL GAAWGGSYVN DFIDRGRVKK VYVMSEAKYR 780
  781 MLPDDIGDWY VRAADGQMVP FSAFSSSRWE YGSPRLERYN GLPSMEILGQ AAPGKSTGEA 840
  841 MELMEQLASK LPTGVGYDWT GMSYQERLSG NQAPSLYAIS LIVVFLCLAA LYESWSIPFS 900
  901 VMLVVPLGVI GALLAATFRG LTNDVYFQVG LLTTIGLSAK NAILIVEFAK DLMDKEGKGL 960
  961 IEATLDAVRM RLRPILMTSL AFILGVMPLV ISTGAGSGAQ NAVGTGVMGG MVTATVLAIF1020
 1021 FVPVFFVVVR RRFSRKNEDI EHSHTVDHH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1oy6A
Description:	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	2.93091397928047	bayes_pls_golite062009
transmembrane transporter activity	2.82224868778929	bayes_pls_golite062009
substrate-specific transporter activity	1.95102182117705	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.86091881396874	bayes_pls_golite062009
ion transmembrane transporter activity	1.79083094640891	bayes_pls_golite062009
cation transmembrane transporter activity	1.72792205593593	bayes_pls_golite062009
drug transmembrane transporter activity	1.51403675564591	bayes_pls_golite062009
	1.44001556200678	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.1603277826799	bayes_pls_golite062009
	1.01602145525561	bayes_pls_golite062009
active transmembrane transporter activity	0.769769685601419	bayes_pls_golite062009
efflux transmembrane transporter activity	0.21543973486818	bayes_pls_golite062009
antiporter activity	0.0217133902283497	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: