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View Structure Prediction Details

Protein: CE33722
Organism: Caenorhabditis elegans
Length: 722 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE33722.

Description E-value Query
Range
Subject
Range
gi|79354855 - gi|79354855|ref|NP_174157.3| ATP binding / aminoacyl-tRNA ligase/ nucleotide binding / tyrosine-tRNA...
421.0 [0..11] [719..20]

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Predicted Domain #1
Region A:
Residues: [1-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAENAEKVE EITEKTKETR ELILRNLQES LGVDKLTKQL ETPGKVPHVY WGTATTGKPH  60
   61 VGYLVPMRKI ADFLQAGLKV TILFADLHAY LDNMKSSWEL LKCRVIYYEN VIKALLQSLD 120
  121 VPIEQLYFKK GTEYQLSREY TDDVLRLSAQ VSQRDALKAG AEVVKQVESP LLSGLLYPLL 180
  181 QALDEQYLKV DGQFGGVDQR KIFILAEEQL PKLKLGKRWH LMNPMVPGLT GTKMSSSEED 240
  241 SKIDVLDEPE KVRSKIMGAA CSRDQPDNGV LSFYNFVLFP IVSPNAIEIE NQQFFDIDSL 300
  301 KRAYLDGKLD ENTLKTFLAD FLVNLLEKVR VRCDTDVVRD AKEKGYNHST DSTEPAIPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.0
Match: 1n3lA
Description: Tyrosyl-tRNA synthetase (TyrRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-oxygen bonds 7.16276509815667 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 7.16276509815667 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.13957775963187 bayes_pls_golite062009
tyrosine-tRNA ligase activity 6.18775771640881 bayes_pls_golite062009
ligase activity 6.11211476973434 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.63681738794687 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
methionine-tRNA ligase activity 2.01261843164558 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
arginine-tRNA ligase activity 1.13743634264647 bayes_pls_golite062009
nucleic acid binding 1.03251266786448 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.844943947059557 bayes_pls_golite062009
nucleotidyltransferase activity 0.564359271862248 bayes_pls_golite062009
binding 0.520077014845626 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.30220012698115 bayes_pls_golite062009
glutamine-tRNA ligase activity 0.118292082006187 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [360-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEAPKIPSLS SEQKQWKDQL LNGNEILIGE ELDRVLADVS PQKPLHLMFI APGKGRFHLG  60
   61 FIAPLLKIKE ISDAGGVPVI ATILVSPLEA FLDNEKVAWA AIQSRAVYFR EMFISLIKHL 120
  121 KLDGLVKVEI AGEHDKYLDR EYVLDFYKMA SAVSRDESTV CD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.73
Match: 1n3lA
Description: Tyrosyl-tRNA synthetase (TyrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [522-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNSLSGNLVP LIYALNAQMT RPDILIIGAD SQVFADLCSR LLRSFGYPAI AHLLIPTIPG  60
   61 CNGQKMSCSI PDFLLDPLDT PKQLKTKIAR SFCEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1ffyA
Description: Isoleucyl-tRNA synthetase (IleRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [617-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNLDGNVAMQ LAEHIVFPIL NGAALHIQRA PDNGGDVEVT NYKQLEQEFV IGTKNEQQFP  60
   61 LHPADLKNAV VGVINRLFDG VRADFAEKPR QKLVTDAFST SKGKKK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.61
Match: 2cycA
Description: Crystal structure of Tyrosyl-tRNA Synthetase complexed with L-tyrosine from Pyrococcus horikoshii
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle