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View Structure Prediction Details

Protein: lin-45
Organism: Caenorhabditis elegans
Length: 614 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-45.

Description E-value Query
Range
Subject
Range
gi|422343, gi|28... - gi|447156|prf||1913436A lraf protein, pir||S33261 protein kinase lin-45 (EC 2.7.1.-) - Caenorhabditi...
297.0 [0..43] [612..1]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAMAVLYSV CHFHGGWNRR KSAPKSPVTS SQTPSSSSTR RRMSRINFKK SSASTTPTSP  60
   61 HCPSPRLISL PRCASSSIDR KDQASPMASP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [91-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STPLYPKHSD SLHSLSGHHS AGGAGTSDKE PPKFKYKMIM VHLPFDQHSR VEVRPGETAR  60
   61 DAISKLLKKR NITPQLCHVN ASSDPKQESI ELSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1rrbA
Description: THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.35732272412639 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.63853240069891 bayes_pls_golite062009
kinase activity 1.62384132584197 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.51475136357956 bayes_pls_golite062009
transferase activity 1.25776281736571 bayes_pls_golite062009
protein kinase activity 1.13077363367159 bayes_pls_golite062009
protein serine/threonine kinase activity 0.673589832597734 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
protein tag 0.00311613478935058 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [185-285]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TMEEIASRLP GNELWVHSEY LNTVSSIKHA IVRRTFIPPK SCDVCNNPIW MMGFRCEFCQ  60
   61 FKFHQRCSSF APLYCDLLQS VPKNEDLVKE LFGIASQVEG P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.045757
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.36195429973813 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10625597744594 bayes_pls_golite062009
kinase activity 2.03632850156074 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.8531437045627 bayes_pls_golite062009
transferase activity 1.4550521488922 bayes_pls_golite062009
GTPase regulator activity 1.39167263636091 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.37139209958305 bayes_pls_golite062009
protein kinase activity 1.34251805835141 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
protein serine/threonine kinase activity 0.956859696337723 bayes_pls_golite062009
enzyme regulator activity 0.911061212692491 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.907368864863833 bayes_pls_golite062009
small GTPase regulator activity 0.661240850692236 bayes_pls_golite062009
transcription regulator activity 0.487499907025216 bayes_pls_golite062009
catalytic activity 0.194464246602439 bayes_pls_golite062009
nucleic acid binding 0.0210137897362572 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [286-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRSVAEIVLA NLAPTSGQSP AATPDSSHPD LTSIKRTGGV KRHPMAVSPQ NETSQLSPSG  60
   61 PYPRDRSSSA PNINAINDEA TVQHNQRILD ALEAQRLEEE SRDKTGSLLS TQARHRPHFQ 120
  121 SGHILSGARM NRLHPLVDCT PLGSNSPSST CSSPPGGLIG QPTLGQSPNV SGSTTSSLVA 180
  181 AHLHTLPLTP PQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [478-614]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAPPQKISPG FFRNRSRSPG ERLDAQRPRP PQKPHHEDWE ILPNEFIIQY KVGSGSFGTV  60
   61 YRGEFFGTVA IKKLNVVDPT PSQMAAFKNE VAVLKKTRHL NVLLFMGWVR EPEIAIITQW 120
  121 CEGSSLYRHI HVQGDLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 2fb8A
Description: No description for 2fb8A was found.

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