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View Structure Prediction Details

Protein: nhr-106
Organism: Caenorhabditis elegans
Length: 382 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-106.

Description E-value Query
Range
Subject
Range
gi|114627460 - gi|114627460|ref|XP_520345.2| PREDICTED: hypothetical protein [Pan troglodytes]
269.0 [0..2] [381..271]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTTCEICEV PAHGIHFGAI TCRGCAAFFR RAVNTKTNRK SCKYSSNCTN FTGKFPQCKS  60
   61 CRMRKCIKMG MMPEKVK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1lo1A
Description: Steroid hormone receptor Err2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.18770607371139 bayes_pls_golite062009
protein binding 0.699012253331291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-382]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMQPISQSLE IFVSRPNLIL FTNNYDKTRN YIDVSNLITR GLEILKQGFP TPLGIGKTNL  60
   61 ERMASGVEFS TAESKIVDVV TGKSVSMVWE FDFISTAKWL TRLQDFCTLP MRIQMQLLQT 120
  121 IWHVWSRMYK VVKSSELRKK HADSSNLFQV LDQFHVNLGT TKLDVSWLTT YSYEEIKYFL 180
  181 YGIDDDIYLQ SAITAASKLE LTDVELTYMA AQTCFQYAQN RFAGTEIAEV CAKFQEILAN 240
  241 DLHTYYTKDH KRTSNYAGKL SQMLKCVQEI QKSIRTTRER TTIARTFDIY ITDFSNPEMF 300
  301 IDSGC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.154902
Match: 1xdkB
Description: Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.07679393058916 bayes_pls_golite062009
protein binding 1.4692467191721 bayes_pls_golite062009
transcription regulator activity 1.38569381220638 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.33970394025402 bayes_pls_golite062009
receptor activity 1.27827487658808 bayes_pls_golite062009
DNA binding 1.07558579137079 bayes_pls_golite062009
nucleic acid binding 0.843756208408716 bayes_pls_golite062009
signal transducer activity 0.729591594314124 bayes_pls_golite062009
molecular transducer activity 0.729591594314124 bayes_pls_golite062009
transcription factor activity 0.523911554416 bayes_pls_golite062009
sequence-specific DNA binding 0.14253203697325 bayes_pls_golite062009
transcription activator activity 0.0654022419611198 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle