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View Structure Prediction Details

Protein: unc-129
Organism: Caenorhabditis elegans
Length: 407 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-129.

Description E-value Query
Range
Subject
Range
gi|45361239, gi|... - gi|45361239|ref|NP_989197.1| bone morphogenetic protein 7, gene 1 [Xenopus (Silurana) tropicalis], g...
263.0 [0..21] [406..45]

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Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRLPIVLLL SVFSIANCAK VDVDLINETI RDLLHFKSSD PNVTSFHRSS HTLTEHMKNL  60
   61 YENFIDE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [68-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNEDGNLVR AIEPAVGKFE GQEVLVFDVE GFDSHESIMR AELHFYLRRR DSFARRRSRQ  60
   61 IRAKSVCVNE YCRQQTLKKI RVGGDENLEE YKVIWDATKS VFDSYHLDAK QAVFRITREH 120
  121 SKMRPYAEMI R

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [199-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSTPFLVIYS KVNHTLDTVS VMKQTEQTKR KRRDLGNEEL REYYNYNSIP LDNDDREPIK  60
   61 RKNGKKNSLS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [269-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEISSEDVWQ GFGEETSREE RERIANEELA NDVRVVLLQN KNRCHKEGVL VSLKHFGWDR  60
   61 YVIEPKTIET SFCKGKCAKP MLTSGKASNH AMLQSLFAAE PVCCAPTNLK SLNFWYRDEK 120
  121 GRTVIRNYSK MLIGSCSCL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.69897
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.69992067408072 bayes_pls_golite062009
receptor binding 2.08021343073973 bayes_pls_golite062009
binding 1.94128368349087 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.36183834539535 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.15487182590328 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.15487182590328 bayes_pls_golite062009
protein dimerization activity 0.803483953206309 bayes_pls_golite062009
growth factor activity 0.61315906855544 bayes_pls_golite062009
protein homodimerization activity 0.50995657444857 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 0.495685919978181 bayes_pls_golite062009
identical protein binding 0.46701037831689 bayes_pls_golite062009
growth factor binding 0.115424337995679 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle