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View Structure Prediction Details

Protein: ptp-1
Organism: Caenorhabditis elegans
Length: 624 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ptp-1.

Description E-value Query
Range		 Subject
Range
ptp-1 - protein tyrosine phosphatase (non receptor type) and band 4.1-like domain status:Partially_confirmed...
 434.0 [0..33] [624..429]

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Predicted Domain #1
Region A:
Residues: [1-121] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVPAFVGKA CLKLKGLCVN VWTATVATCQ ENAEIDEKLP PRAFRESSAP SLRQQRLSKE  60
   61 AIYYGTQESC DEKSWTPSMA CTSTSPGIHA STASVRPVSS GSTPNGASRK SANSGYSGYG 120
  121 Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 1uewA
Description: Solution Structure of The forth PDZ Domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [122-182] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATQTQQPTST TNASYSPYLN GTISRSSGAA VAKAAARGLP PTNQQAYNTS SPRNSVASYS  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [183-293] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FASAGIGGSP PRSKRSPQSN KSSSPVGEDQ VVTIKMRPDR HGRFGFNVKG GADQNYPVIV  60
   61 SRVAPGSSAD KCQPRLNEGD QVLFIDGRDV STMSHDHVVQ FIRSARSGLN G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1wh1A
Description: Solution structure of the fourth PDZ domain of KIAA1095 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.40921081688513 bayes_pls_golite062009
binding 3.2595117613307 bayes_pls_golite062009
phosphatase activity 2.36315753814254 bayes_pls_golite062009
phosphoprotein phosphatase activity 2.3400854724675 bayes_pls_golite062009
phosphoric ester hydrolase activity 2.31425709018481 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.0332243159956 bayes_pls_golite062009
kinase activity 1.60310055540266 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.42576125485675 bayes_pls_golite062009
transcription regulator activity 1.37626136403014 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
protein tyrosine phosphatase activity 1.10674192505247 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
molecular transducer activity 1.06018756723145 bayes_pls_golite062009
signal transducer activity 1.06018756723145 bayes_pls_golite062009
transferase activity 1.02891276124789 bayes_pls_golite062009
PDZ domain binding 0.87883331498113 bayes_pls_golite062009
receptor binding 0.867295068429704 bayes_pls_golite062009
substrate-specific transporter activity 0.755223974149211 bayes_pls_golite062009
beta-catenin binding 0.740091060781601 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
peptidase activity 0.555029889463539 bayes_pls_golite062009
protein kinase binding 0.54934142458843 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.549085929250683 bayes_pls_golite062009
kinase binding 0.541050170070789 bayes_pls_golite062009
hydrolase activity 0.534910002338727 bayes_pls_golite062009
enzyme binding 0.46071739042312 bayes_pls_golite062009
cell adhesion molecule binding 0.403457741099606 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.281958912690177 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009
phosphatase binding 0.24515474358339 bayes_pls_golite062009
structural molecule activity 0.153277808949873 bayes_pls_golite062009
cytoskeletal protein binding 0.0187659836234897 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [294-624] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELHLTIRPN VYRLGEEVDE PDSTMVPEPA RVADSVPNSD KLSKSLQLLA DSLNSGKVVD  60
   61 HFEMLYRKKP GMSMNICRLT ANLAKNRYRD VCPYDDTRVT LQASPSGDYI NANYVNMEIP 120
  121 SSGIVNRYIA CQGPLAHTSS DFWVMVWEQH CTTIVMLTTI TERGRVKCHQ YWPRVFETQE 180
  181 YGRLMIKCIK DKQTTNCCYR EFSIRDRNSS EERRVTQMQY IAWPDHGVPD DPKHFIQFVD 240
  241 EVRKARQGSV DPIVVHCSAG IGRTGVLILM ETAACLVESN EPVYPLDIVR TMRDQRAMLI 300
  301 QTPGQYTFVC ESILRAYHDG TIKPLAEYSK R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.522879
Match: 2i75A
Description: No description for 2i75A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle