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View Structure Prediction Details

Protein: clec-73
Organism: Caenorhabditis elegans
Length: 577 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clec-73.

Description E-value Query
Range
Subject
Range
clec-79 - clec family, C-type lectin status:Partially_confirmed UniProt:Q20528 protein_id:AAC24390.1
335.0 [0..1] [577..1]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTKVVSVWL GFIVSAFFTT SWGLLLNSDE GFEKACKQSG GDYTQRAGND SNTGDICLMT  60
   61 FQAVATDMDA ARDFCNIKAP WRLREAKIDK S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-280]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDSIPVIICD VEATFTCNAG WIQMFGYCFK MSEVHDRYTR EKAEQYCKDQ AGPSFQGEIA  60
   61 GIHHRYILTP WRSYFTRLQQ FWIRAPETWD EYVIKTDKVD GDNLALSFYD VHPDFSVPQN 120
  121 AMIKINGKVE LQALCQYKPA ITPAEINYMG RRYSEIYYPT VPVKDGIIVR SASSYTRSSN 180
  181 QSDVCKKVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.39794
Match: 1tdqB
Description: Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13629480035749 bayes_pls_golite062009
carbohydrate binding 0.44675717945952 bayes_pls_golite062009
protein binding 0.059857076934361 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [281-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPYMYSKESQ FFPDPDSMEQ LAKLEPEAYS LMRSPLVSNS VERYRTNRYC QAPSNPHYEV  60
   61 VLGGKKTANF VVEENKIKGK PTCDNMMSVS ISHFKGQAPE FHPMVDSQSL PIWCKLGKVV 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [401-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYKYKVTPGW TDFRRLNGQV ALHWLSKDKL TFADAAAACE AKGANLAGIN SLKEAEQLGN  60
   61 HVVGANLNNE QFWLGAQRRT ECLENNDWKP PCTRDKIFEW MNNVATDFRS EWWKKNNNLH 120
  121 SPNPSGTGQR CLSFAFGDLW WSYKGHTGFL DDIECHTELR YFCSKMAPFT ECEENCD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 1sl6A
Description: Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13629480035749 bayes_pls_golite062009
carbohydrate binding 0.44675717945952 bayes_pls_golite062009
protein binding 0.059857076934361 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle