YRC Public Data Repository - Protein Structure Prediction

Protein:	thk-1
Organism:	Caenorhabditis elegans
Length:	269 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for thk-1.

Description	E-value	Query Range	Subject Range
gi\|187035776, gi... - gi\|39581835\|emb\|CAE60728.1\| Hypothetical protein CBG04406 [Caenorhabditis briggsae], gi\|187035776\|em... gi\|157758291 - gi\|157758291\|ref\|XP_001671489.1\| Hypothetical protein CBG04406 [Caenorhabditis briggsae AF16]	339.0	[0..10]	[266..1]
gi\|22324517 - gi\|22324517\|gb\|AAM95606.1\|AF395663_1 thymidine kinase [Trypanosoma brucei]	282.0	[0..9]	[247..180]
gi\|71746582 - gi\|71746582\|ref\|XP_822346.1\| thymidine kinase [Trypanosoma brucei TREU927] gi\|70832014 - gi\|70832014\|gb\|EAN77518.1\| thymidine kinase, putative [Trypanosoma brucei]	280.0	[0..9]	[247..180]
gi\|60653309, gi\|... - gi\|60653309\|gb\|AAX29349.1\| thymidine kinase 1 soluble [synthetic construct], gi\|33303757\|gb\|AAQ02392...	276.0	[0..23]	[226..8]
TK1 - thymidine kinase 1, soluble gi\|60656371, gi\|... - gi\|60656371\|gb\|AAX32749.1\| thymidine kinase 1 [synthetic construct], gi\|60656369\|gb\|AAX32748.1\| thym... HGNC:11830\|MIM:1... - kinase 1, soluble ENSPTRT00000017814 - null	276.0	[0..23]	[226..8]
gi\|202073 - gi\|202073\|gb\|AAA40451.1\| cytosolic thymidine kinase	274.0	[0..23]	[230..8]
gi\|109118477 - gi\|109118477\|ref\|XP_001107944.1\| PREDICTED: thymidine kinase 1, soluble isoform 3 [Macaca mulatta]	273.0	[0..23]	[226..8]
gi\|252871, gi\|298946 - gi\|298946\|gb\|AAB26001.1\| thymidine kinase [Mus sp.], gi\|252871\|gb\|AAB22782.1\| thymidine kinase, TK {... KITH_MOUSE - Thymidine kinase, cytosolic OS=Mus musculus GN=Tk1 PE=1 SV=3	272.0	[0..23]	[230..8]

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Predicted Domain #1

Region A:
Residues: [1-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIEAAKNEM TCCSSNSSLS DFNTLPRCPN RVGSITVILG PMFSGKTTEL LRLHDRQIIA  60
   61 KRTCVLVKYA GDTRYDADLV ATHSKMTGQG RTVKAHRLSE VQSQIFNDEV QVVSIDEGQF 120
  121 FEDLAETCEE LAQRGKVVCV AALNGTFERK PFPQISLLLP YANEIKQVTA VCVECGSQAN 180
  181 FSFRSTLDKK VEVIGGSDTY TALCRECYVQ KSEEKDAEEQ MKTGCDKNEN DITGIFLAKK 240
  241 EQRSDGSVSP PRKKIGLSKS MALEATART

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.30103
Match:	2orvA
Description:	No description for 2orvA was found.

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
kinase activity	2.0779386406753	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
binding	1.88744046151476	bayes_pls_golite062009
protein binding	1.41749048987708	bayes_pls_golite062009
DNA binding	1.22619720972604	bayes_pls_golite062009
nucleic acid binding	1.17199530230795	bayes_pls_golite062009
transcription regulator activity	1.16376707327858	bayes_pls_golite062009
transcription factor activity	0.472763834470731	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
catalytic activity	0.101795606736461	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: