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View Structure Prediction Details

Protein: ers-1
Organism: Caenorhabditis elegans
Length: 786 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ers-1.

Description E-value Query
Range
Subject
Range
gi|73985557 - gi|73985557|ref|XP_533833.2| PREDICTED: similar to glutaminyl-tRNA synthetase isoform 1 [Canis famil...
839.0 [0..1] [783..1]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATKEELLSL GLSDSKVAET LKNVKLTETI GSIVKLASES GEISKQKGTL LYQLATKLKP  60
   61 QVAAHTPLVV KYIMNDGIKT EPQLSAAIEY LLSHTVKGIQ VPDFEKSCGV GVVVTIDDIE 120
  121 AAVTKVIGQH REKIVAERYS FPAGKLLGEL RALLP

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 82.638272
Match: PF04558.6
Description: No description for PF04558.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [156-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WADGAITKKE VDLRFLELLG PKTAEDLAPK KKEKKPEGPK PSKDAAAAAT APGTKNQKEA  60
   61 SPEEFADGAE TMDELLRTRA HFHKVGENFK QDG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 1iq0A
Description: Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [249-786]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVTTPKTAEL LKAHVAAVGG KVVTRFPPEP NGVLHIGHAK AININFGYAK AMGGVCNLRF  60
   61 DDTNPEKEEE KFFSAIEDIV HWLGYDPARV THSSDNFQQL YLWAVKLIQK GLAFVCHQKV 120
  121 EEMRGFEVQL SPWRERPIEE NIQLFEDMKN GKFDEGEATL RLKLTLEEGK VDPVAYRIKY 180
  181 VPHHRTGNQW CIYPTYDYTH CLCDSIENIT HSLCTKEFQS RRSSYYWLCN ALDIYCPVQW 240
  241 EYGRLNVNYT VVSKRKILKL ITTKTVNDWD DPRLFTLTAL RRRGIPSEAI NRFVAKLGLT 300
  301 MSQMVIDPHV LDATVRDYLN IHAPRTMAVL EGLKLTIENF SELNLPSSVD VPDFPSDPTD 360
  361 PRKHSVSVDR EIFIEKSDYK PDDSDKSFRR LTPKQAVGLK HIGLVLRFVK EVKDAEGHVT 420
  421 EVVVKAEKLS EKDKPKAFIH WVAKPVSCEV RLYDRLFKSK NPEDAQLVPG GFLSDINPDS 480
  481 LTVVYNALID QSIAKSKVYD RFQFERIGFF CVDRDSTSST LVFNRTVMLK DGGASGKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 162.0
Match: 1o0bA
Description: Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutamine-tRNA ligase activity 7.66556935228325 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 7.16276509815667 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.16276509815667 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.13957775963187 bayes_pls_golite062009
ligase activity 6.11211476973434 bayes_pls_golite062009
lysine-tRNA ligase activity 4.64665624411373 bayes_pls_golite062009
structural constituent of ribosome 4.61484562096458 bayes_pls_golite062009
structural molecule activity 4.261982318682 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.63681738794687 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
5S rRNA binding 2.25646775578129 bayes_pls_golite062009
rRNA binding 2.12571610259264 bayes_pls_golite062009
methionine-tRNA ligase activity 2.01261843164558 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.88984817882585 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
arginine-tRNA ligase activity 1.13743634264647 bayes_pls_golite062009
nucleotidyltransferase activity 1.06535308346284 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.844943947059557 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.625793556381714 bayes_pls_golite062009
binding 0.47302762432927 bayes_pls_golite062009
nucleic acid binding 0.161799496958314 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle