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View Structure Prediction Details

Protein: prmt-2
Organism: Caenorhabditis elegans
Length: 630 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for prmt-2.

Description E-value Query
Range		 Subject
Range
gi|76640128 - gi|76640128|ref|XP_870373.1| PREDICTED: similar to Protein arginine N-methyltransferase isoform 3 [B...
 354.0 [0..1] [628..3]

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Predicted Domain #1
Region A:
Residues: [1-296] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLEKINQKT GEREWVVAEE DYDMAQELAR SRFGDMILDF DRNDKFLAGL KTTIAEKKHE  60
   61 NTDGKVHVLD IGTGTGLLSL MAAREGADKV TALEVFKPMG DCARHITSNS PWSDKITVIS 120
  121 ERSTDVSQIG GSRADIIVAE VFDTELIGEG ALRTFKEALE RLAKPGCRVV PSTGNVYIVP 180
  181 VESHLLKMFN DIPRLNGEKD EEPLGRCSGT AAVFDVQLSE MKTHEFRELS EPIVAFKFDF 240
  241 EHEEKIIFDE SFVREAVAHS SGTIDALLMW WDIDMDRNGT TFIDMGPKWK NKNNYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1kp9A
Description: CmaA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein methyltransferase activity 5.03267617653315 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 4.4632173842967 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 4.42061797259061 bayes_pls_golite062009
histone methyltransferase activity 4.40911163698179 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 4.39379274790202 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 3.87145704230189 bayes_pls_golite062009
DNA-methyltransferase activity 3.6879779213105 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 3.55785970363721 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.86617323549909 bayes_pls_golite062009
[myelin basic protein]-arginine N-methyltransferase activity 2.48953871767053 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 1.99067501725601 bayes_pls_golite062009
RNA methyltransferase activity 1.86200407013263 bayes_pls_golite062009
rRNA methyltransferase activity 1.79395300104934 bayes_pls_golite062009
transcription regulator activity 1.55725596651484 bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity 1.55340762301836 bayes_pls_golite062009
binding 1.54733751399119 bayes_pls_golite062009
histone methyltransferase activity (H2A-R3 specific) 1.49229188826344 bayes_pls_golite062009
histone methyltransferase activity (H3-R2 specific) 1.49229188826344 bayes_pls_golite062009
DNA binding 1.46895871345911 bayes_pls_golite062009
nucleic acid binding 1.31440474302645 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
RNA binding 1.10729923226801 bayes_pls_golite062009
histone binding 0.964746527369069 bayes_pls_golite062009
tRNA methyltransferase activity 0.868107614027708 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
mRNA methyltransferase activity 0.73490663449605 bayes_pls_golite062009
mRNA (guanine-N7-)-methyltransferase activity 0.73490663449605 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.102141401712309 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.0251895714734512 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [297-630] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMVQQCWERV CIYSRNTNFY QLLFFSKSRS YCVCGLHSML SRQTVYHVNE MFENQKFKDE  60
   61 VDKLSKGLHV ATVGEGSFLG LLAAKTAKRV TIIDGNERFR DIFFKYIHYY KLTNVEIIEK 120
  121 VTSLTDSPDI VLAEPFYMSA MNPWNHLRFL YDVEVLKMMH GDELRVEPHM GVLKAIPEKF 180
  181 EDLQNIASDV GTVNGFDLSF FDEISTKART ATDAIVDEQS LWEYAGIVKG DAVEILRFPI 240
  241 DGRVSSQKCV VNIDNMSSSN AIPMWMEWEF GGINLSTGLL SISSAGVPEW NKGYKQGVYF 300
  301 PITALRNDKS LCLHALFDKS TGDINFQFGK SEDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.522879
Match: 1or8A
Description: Structure of the Predominant protein arginine methyltransferase PRMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein methyltransferase activity 5.03267617653315 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 4.4632173842967 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 4.42061797259061 bayes_pls_golite062009
histone methyltransferase activity 4.40911163698179 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 4.39379274790202 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 3.87145704230189 bayes_pls_golite062009
DNA-methyltransferase activity 3.6879779213105 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 3.55785970363721 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.86617323549909 bayes_pls_golite062009
[myelin basic protein]-arginine N-methyltransferase activity 2.48953871767053 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 1.99067501725601 bayes_pls_golite062009
RNA methyltransferase activity 1.86200407013263 bayes_pls_golite062009
rRNA methyltransferase activity 1.79395300104934 bayes_pls_golite062009
transcription regulator activity 1.55725596651484 bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity 1.55340762301836 bayes_pls_golite062009
binding 1.54733751399119 bayes_pls_golite062009
histone methyltransferase activity (H2A-R3 specific) 1.49229188826344 bayes_pls_golite062009
histone methyltransferase activity (H3-R2 specific) 1.49229188826344 bayes_pls_golite062009
DNA binding 1.46895871345911 bayes_pls_golite062009
nucleic acid binding 1.31440474302645 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
RNA binding 1.10729923226801 bayes_pls_golite062009
histone binding 0.964746527369069 bayes_pls_golite062009
tRNA methyltransferase activity 0.868107614027708 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
mRNA methyltransferase activity 0.73490663449605 bayes_pls_golite062009
mRNA (guanine-N7-)-methyltransferase activity 0.73490663449605 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.102141401712309 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.0251895714734512 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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