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View Structure Prediction Details

Protein: klf-1
Organism: Caenorhabditis elegans
Length: 497 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for klf-1.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
619.0 [0..2] [496..2388]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSSINATS SREPLIHIPN KPSLSIDPLA RADRSVHLSP SFFQPGLSSI SSENDDAEQR  60
   61 IHEATRSFNQ FGHQFYESIR ELSESTSAYE RLKANALRRK LENTFGNDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [110-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAATSSSSSS VFERQSDFSA FAPYKNSHFD STQSLFQPTT SFNDRLEQIK SDFIAEHQKS  60
   61 MSSFSGFNTP TTALGAAFQG MQVKKSAFAP VLLRENLDTR RPGGHLISDI LNRDPLPQSR 120
  121 NLNLNMAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.61993443866178 bayes_pls_golite062009
nucleic acid binding 0.731952128233945 bayes_pls_golite062009
catalytic activity 0.616333600617445 bayes_pls_golite062009
DNA binding 0.535555864236874 bayes_pls_golite062009
protein binding 0.493759671494013 bayes_pls_golite062009
transcription regulator activity 0.388095816166232 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [238-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVPIRLIHST SNFDIASSSS GDSGHQDHES IVVEDADMDS PTSPCVKRSA MNFDLRDEPL  60
   61 TVNVESVSST SDLPSSVSSS VNSFVYQNFD PLEFKRKIDE LTASACLAVM PDANGQVDPM 120
  121 AIKTQLDAIK KQMEEHQTHM AEASQRLHVD SSLEDSNCEP SPSSSYDASE PSVKRLHHCT 180
  181 H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [419-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNCGKVYTKS SHLKAHFRTH TGEKPYECSW DGCDWRFARS DELTRHYRKH TGDRPFKCSQ  60
   61 CSRAFSRSDH LSLHMKRHF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1f2iG
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle