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View Structure Prediction Details

Protein: klf-1
Organism: Caenorhabditis elegans
Length: 497 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for klf-1.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
619.0 [0..2] [496..2388]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSSINATS SREPLIHIPN KPSLSIDPLA RADRSVHLSP SFFQPGLSSI SSENDDAEQR  60
   61 IHEATRSFNQ FGHQFYESIR ELSESTSAYE RLKANALRRK LENTFGNDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [110-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAATSSSSSS VFERQSDFSA FAPYKNSHFD STQSLFQPTT SFNDRLEQIK SDFIAEHQKS  60
   61 MSSFSGFNTP TTALGAAFQG MQVKKSAFAP VLLRENLDTR RPGGHLISDI LNRDPLPQSR 120
  121 NLNLNMAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.61993443866178 bayes_pls_golite062009
nucleic acid binding 0.731952128233945 bayes_pls_golite062009
catalytic activity 0.616333600617445 bayes_pls_golite062009
DNA binding 0.535555864236874 bayes_pls_golite062009
protein binding 0.493759671494013 bayes_pls_golite062009
transcription regulator activity 0.388095816166232 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [238-418]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVPIRLIHST SNFDIASSSS GDSGHQDHES IVVEDADMDS PTSPCVKRSA MNFDLRDEPL  60
   61 TVNVESVSST SDLPSSVSSS VNSFVYQNFD PLEFKRKIDE LTASACLAVM PDANGQVDPM 120
  121 AIKTQLDAIK KQMEEHQTHM AEASQRLHVD SSLEDSNCEP SPSSSYDASE PSVKRLHHCT 180
  181 H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [419-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNCGKVYTKS SHLKAHFRTH TGEKPYECSW DGCDWRFARS DELTRHYRKH TGDRPFKCSQ  60
   61 CSRAFSRSDH LSLHMKRHF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 1f2iG
Description: ZIF268
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle