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View Structure Prediction Details

Protein: tig-2
Organism: Caenorhabditis elegans
Length: 366 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tig-2.

Description E-value Query
Range
Subject
Range
gi|45361239, gi|... - gi|45361239|ref|NP_989197.1| bone morphogenetic protein 7, gene 1 [Xenopus (Silurana) tropicalis], g...
290.0 [0..2] [366..12]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFEFSILLG FLVPRGDSKG IYFVEERNGK TYTQPLTGQA TDKIGEQIRE LFNIDINPNG  60
   61 PAVKANNYVS TYMKRLYKQL ENYEHGENHN EEEVNAWLSA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [101-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRIVSHMAQE VSHRLDDGSY SIRFAKEHVP AKEGQSIVRA QLRIHIQGIV SPVFFYIEDT  60
   61 NLPGDTVLVS SDDPTVVTDV TTMVDRWSHL QLSTLPIVTA RASTNDELKI EAFLVIALKD 120
  121 EDAGPPKKRS R

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [232-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSASTTPISA PPMRQKVKRS ESAYFEKPNE NERCQRKGLY VDFDILGWKQ WVIAPEGFSA  60
   61 FYCSGDCSAP FSKEMNATSH AIVQSTLHRV RPNSTTPAKC APSSLGSYKI LFVDQNKQVQ 120
  121 IKRYRDMVVD ECGCH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1bmpA
Description: BONE MORPHOGENETIC PROTEIN-7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
type II transforming growth factor beta receptor binding 6.0109591386237 bayes_pls_golite062009
receptor serine/threonine kinase binding 4.8369569327215 bayes_pls_golite062009
receptor binding 4.70889547404918 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 4.69128752159226 bayes_pls_golite062009
transforming growth factor beta receptor binding 4.69128752159226 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 4.17375537569815 bayes_pls_golite062009
growth factor activity 4.01406832911234 bayes_pls_golite062009
cytokine activity 3.61376517935324 bayes_pls_golite062009
fibronectin binding 3.5904111848601 bayes_pls_golite062009
protein binding 3.57959800431189 bayes_pls_golite062009
binding 2.85157432803513 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 2.76400237542695 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 2.68337714155403 bayes_pls_golite062009
glycosaminoglycan binding 2.49731836866959 bayes_pls_golite062009
platelet-derived growth factor receptor binding 2.45798835344627 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 2.42595321135263 bayes_pls_golite062009
growth factor binding 2.41942870726502 bayes_pls_golite062009
cell surface binding 2.33284053060339 bayes_pls_golite062009
heparin binding 2.11784489374422 bayes_pls_golite062009
hormone activity 1.83166472515554 bayes_pls_golite062009
protein dimerization activity 1.82426827198541 bayes_pls_golite062009
transcription regulator activity 1.57604808199471 bayes_pls_golite062009
protein homodimerization activity 1.45915811604115 bayes_pls_golite062009
pattern binding 1.34327634476459 bayes_pls_golite062009
identical protein binding 1.32909205585546 bayes_pls_golite062009
platelet-derived growth factor binding 1.16893591942376 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein kinase activity 1.04675700066451 bayes_pls_golite062009
transcription activator activity 1.00293277340817 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.942223934173215 bayes_pls_golite062009
morphogen activity 0.91146826241391 bayes_pls_golite062009
protein heterodimerization activity 0.88308874209284 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
protein serine/threonine kinase activity 0.638661528852015 bayes_pls_golite062009
vascular endothelial growth factor receptor 3 binding 0.385087890820529 bayes_pls_golite062009
transforming growth factor beta binding 0.332742217753928 bayes_pls_golite062009
catalytic activity 0.105223830172599 bayes_pls_golite062009
kinase activity 0.0830844256009901 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle