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View Structure Prediction Details

Protein: sptl-2
Organism: Caenorhabditis elegans
Length: 558 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sptl-2.

Description E-value Query
Range
Subject
Range
gi|67517849, gi|... - gi|67517849|ref|XP_658706.1| hypothetical protein AN1102.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
458.0 [0..2] [545..75]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRRTDSLCL DEYLSSELKK RTHILECAWN QEHDDDEEEE EVKVDQGSEE TTSSHDIYGD  60
   61 VGKRAPNEFE KIDRLTTIKV YIAWLALFVF AHIREYVTRF GFVKDLSSKE NAKMKDFVPL 120
  121 FSDFEAFYQR NCYIKVRDVF ERPICSVPG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [150-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATVDLVDRVS HDGNWTYEYP GTRTNVINVG SYNYLGFAQS AGPCAEQSAS SIDREGLSCC  60
   61 TTVHERGRSV SQAKLEKLVA EFLGVEDAIC FSMGFATNSM NAPCLVDKHS LIISDKYNHA 120
  121 SLILGCRLSG ASTKVFEHND MESLERILRD AIAYGNPKTH RPYKKILIIV EGIYSMEGSI 180
  181 CNLPGIIALK KKYQAYLYLD EAHSIGAMGK TGKGVVEYWG CDPKDVDILM GTFTKSFGAA 240
  241 GGYIAGSKRT VDHLRAASPT GYYSSPMSPP IAQQIYTSMS IIMGKDGTKD GAQRIERLAR 300
  301 NSHYFRMKLK QNGFIVYGSN DSPVVPMLIY FPTMCGFYGR EMLARNIGCV VVSFPATHMT 360
  361 EGRVRFCISA AHTKEQLDEV LETVNLLGSM SRSKFSKRSH LYKNQKIEW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 86.69897
Match: 1fc4A
Description: 2-amino-3-ketobutyrate CoA ligase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
serine C-palmitoyltransferase activity 9.1839236553858 bayes_pls_golite062009
C-palmitoyltransferase activity 9.1839236553858 bayes_pls_golite062009
C-acyltransferase activity 4.29379571948906 bayes_pls_golite062009
5-aminolevulinate synthase activity 3.15163480353521 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 2.82458180884712 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
N-succinyltransferase activity 1.81799375593294 bayes_pls_golite062009
threonine aldolase activity 1.80396420390785 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 1.74778109525713 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.46601963907552 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.46601963907552 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
transcription regulator activity 1.07873942461292 bayes_pls_golite062009
glycine C-acetyltransferase activity 0.935794708043259 bayes_pls_golite062009
DNA binding 0.886628214497634 bayes_pls_golite062009
nucleic acid binding 0.814403324199462 bayes_pls_golite062009
structural molecule activity 0.811208803619077 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
binding 0.661198018681765 bayes_pls_golite062009
intramolecular transferase activity, transferring amino groups 0.659071155545801 bayes_pls_golite062009
transcription factor activity 0.615294010373048 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.319452731970428 bayes_pls_golite062009
cystathionine beta-lyase activity 0.15938456446406 bayes_pls_golite062009
sulfurtransferase activity 0.0450490929307473 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle