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View Structure Prediction Details

Protein: hrs-1
Organism: Caenorhabditis elegans
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hrs-1.

Description E-value Query
Range
Subject
Range
SYT_COLP3 - Threonine--tRNA ligase OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=thrS PE=3 SV=1
342.0 [0..1] [519..199]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAERKAILM QEAQALGDEI RQLKLDKADQ AIIKEKVALM QAKRKEAGET GAPEKPGKFV  60
   61 LKTG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.33
Match: 2djvA
Description: No description for 2djvA was found.

Predicted Domain #2
Region A:
Residues: [65-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGTRDYGPAQ SALRNSVLQT VTETFNRYGA ETIDTPVFEL RDVLMGKYGE EGGKLVYDLQ  60
   61 DQGGELLSLR YDLTVPFARY LAMNKITNIT RYQIAKVYRR DQPVMSRGRY REFYQCDFDI 120
  121 AGQYDLMLPE AECLGIVDEL LTKLEIGEFF INLNHRLILE GMFAVSGIPA KDFKTICSSV 180
  181 DKLDKTPWED VEQEMINEKF LTKEQTGKLG ELVRFRELNS DLNNLELLEK MSQLPDLGQN 240
  241 DKFKKGAEEL KVLIEYLNVD GVTTVRYEPS LARGLDYYTG AIYEAVAPKA LEGTAVENSE 300
  301 DTAGQPVGVG SVAAGGRYDG LVKMFDSKAN VPCCGVSFGI ERLFAIMEAR QKVAIRTTQT 360
  361 EVYVASAQKN LVRDRKKLVK MLRSAGIKTE MALKANPKLL TQFQYAEERR IPLAIVIGEQ 420
  421 ELKDGVVKLR NVVTRDEQTI KLDQLITAVR DTLAAL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.39794
Match: 1httA
Description: Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 6.0520403280225 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 6.0520403280225 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 6.04138870254626 bayes_pls_golite062009
histidine-tRNA ligase activity 5.91343220471745 bayes_pls_golite062009
ligase activity 4.85905957427768 bayes_pls_golite062009
proline-tRNA ligase activity 3.10945929267718 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 2.99105702052936 bayes_pls_golite062009
serine-tRNA ligase activity 2.46505535069103 bayes_pls_golite062009
glycine-tRNA ligase activity 2.29229136935761 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
binding 1.30923742450698 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
transcription regulator activity 0.375542987753806 bayes_pls_golite062009
protein binding 0.358563180490135 bayes_pls_golite062009
nucleic acid binding 0.281662799812287 bayes_pls_golite062009
DNA binding 0.0309732052586011 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle