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View Structure Prediction Details

Protein: daf-8
Organism: Caenorhabditis elegans
Length: 546 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-8.

Description E-value Query
Range
Subject
Range
SMAD5_CHICK - Mothers against decapentaplegic homolog 5 OS=Gallus gallus GN=SMAD5 PE=2 SV=1
429.0 [0..2] [546..6]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDFPSPEPT DPRLEAMAQK VLEETIITEG DGTIYWALKV TRLLSRVAKK HQCFEAFYDA  60
   61 VIKGDPKTRC CPAHNEKLIG NFGRAIMCVL RAFRFPVIRY ESQVKSILTC RHAFNSHSRN 120
  121 VCLNPYHYRW VEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1mhdA
Description: SMAD MH1 domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [134-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTCQVPPIIV NKELDYGEPP IRTEDALDDW NQKDLKEEQV VASWDVPNVT MRGDEIKLLY  60
   61 DRYAAENGDF QYMNYGNFGS FDGSPCSSTT MSLGSSFASL LQQSNRQDDE EPGYYRSGLS 120
  121 SPASHAASPR EFIPNGNDTI SLDQEMMDDS EVSDIMHSEN FSSENNGNRK PTYADGRPIT 180
  181 PIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [317-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRPLYRSSAL ELGDLSRQAG IYECVEYEES PSWLKLIYYE EGTMIGEKAD VEGHHCLIDG  60
   61 FTASRTDSET RSRFSLGWYN NPNRSPQTAE VRGLIGKGVR FYLLAGEVYV ENLCNIPVFV 120
  121 QSIGANMKNG FQLNTVSKLP PTGTMKVFDM RLFSKQLRTA AEKTYQDVYC LSRMCTVRVS 180
  181 FCKGWGEHYR RSTVLRSPVW FQAHLNNPMH WVDSVLTCMG APPRICSSRT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.221849
Match: 1khuA
Description: Smad1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.72705938702913 bayes_pls_golite062009
binding 2.31656652567204 bayes_pls_golite062009
transcription regulator activity 1.93348471274042 bayes_pls_golite062009
DNA binding 1.64107635602436 bayes_pls_golite062009
nucleic acid binding 1.59899290578262 bayes_pls_golite062009
transcription activator activity 1.1056197205863 bayes_pls_golite062009
sequence-specific DNA binding 0.93638089729878 bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity 0.70979718281225 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.59091508757448 bayes_pls_golite062009
transcription factor activity 0.554078523633227 bayes_pls_golite062009
signal transducer activity 0.29313054064574 bayes_pls_golite062009
molecular transducer activity 0.29313054064574 bayes_pls_golite062009
catalytic activity 0.257477082550163 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity 0.17825540288715 bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity 0.0594594490862095 bayes_pls_golite062009
SMAD binding 0.0361094043816896 bayes_pls_golite062009
receptor signaling protein activity 0.0268350196675502 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle