YRC Public Data Repository - Protein Structure Prediction

Protein:	hpl-1
Organism:	Caenorhabditis elegans
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hpl-1.

Description	E-value	Query Range	Subject Range
gi\|109067205 - gi\|109067205\|ref\|XP_001095397.1\| PREDICTED: similar to chromobox homolog 3 [Macaca mulatta]	140.0	[0..8]	[172..263]
gi\|83699408, gi\|... - gi\|83699408\|ref\|NP_031650.2\| chromobox homolog 3 (Drosophila HP1 gamma) [Mus musculus], gi\|80474659\|...	127.0	[0..17]	[172..10]
gi\|114666540 - gi\|114666540\|ref\|XP_523820.2\| PREDICTED: similar to heterochromatin protein 1 beta [Pan troglodytes]	126.0	[0..43]	[172..191]
gi\|109488886 - gi\|109488886\|ref\|XP_340886.3\| PREDICTED: similar to Chromobox protein homolog 1 (Heterochromatin pro...	126.0	[0..7]	[172..555]
gi\|149033378, gi... - gi\|56799436\|ref\|NP_001008314.2\| chromobox homolog 3 [Rattus norvegicus], gi\|55778344\|gb\|AAH86601.1\| ... gi\|74226967, gi\|... - gi\|94398234\|ref\|XP_001000966.1\| PREDICTED: similar to chromobox homolog 3 [Mus musculus], gi\|9439766... CBX3 - chromobox homolog 3 (HP1 gamma homolog, Drosophila) gi\|155372117, gi... - gi\|155372117\|ref\|NP_001094668.1\| chromobox homolog 3 [Bos taurus], gi\|151554829\|gb\|AAI47956.1\| CBX3 ... CBX3_PONPY - Chromobox protein homolog 3 - Pongo pygmaeus (Orangutan) CBX3_PONAB - Chromobox protein homolog 3 OS=Pongo abelii GN=CBX3 PE=2 SV=1 gi\|48249221 - gi\|48249221\|gb\|AAT40863.1\| heterochromatin protein 1 gamma [Cricetulus griseus] gi\|208965998, gi... - gi\|208965998\|dbj\|BAG73013.1\| chromobox homolog 3 [synthetic construct], gi\|190691189\|gb\|ACE87369.1\| ... ENSOCUP000000205... - pep:novel chromosome:oryCun2:17:47944687:47945238:-1 gene:ENSOCUG00000022201 transcript:ENSOCUT00000... ENSCJAT00000015514 - null tr\|M3WM73\|M3WM73... - Uncharacterized protein OS=Felis catus GN=CBX3 PE=4 SV=1 gi\|114612472, gi... - gi\|114612480\|ref\|XP_001161376.1\| PREDICTED: chromobox homolog 3 isoform 6 [Pan troglodytes], gi\|1146... gi\|73976144, gi\|... - gi\|73976144\|ref\|XP_864475.1\| PREDICTED: similar to chromobox homolog 3 isoform 5 [Canis familiaris],...	126.0	[0..17]	[172..10]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQNPVRST RGNSLRAREA QQAQDAPLFQ ESSSNVFVVE KVLNKRLTRG GSEYYIKWQG  60
   61 FPESECSWEP IENLQCDRMI QEYEKEAAKR TTRKRRYSPQ PSTSSSAELQ PSTSDEWAGK 120
  121 TLKTIIGITK APGELHFLCK FSDDSVHLIP LREANVRFPS QVIKFYETRL VLQGVSPTIP 180
  181 GGMS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.30103
Match:	2b2tA
Description:	Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and phosphothreonine 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.72796089835126	bayes_pls_golite062009
chromatin binding	0.992646667007469	bayes_pls_golite062009
transcription repressor activity	0.90959660710929	bayes_pls_golite062009
protein binding	0.89835439354196	bayes_pls_golite062009
transcription regulator activity	0.29923452744967	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: