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View Structure Prediction Details

Protein: egl-43
Organism: Caenorhabditis elegans
Length: 543 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for egl-43.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
695.0 [0..14] [529..2381]

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Predicted Domain #1
Region A:
Residues: [1-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIDTDFLTS VEVKEDELHG NVLIAVTQIA LGRTIGVIDK ATPNDSNALL ILNLIKEADD  60
   61 GEDANICMRQ EDRKTFLQTS KIINIGERLL LQRLSEEECD EEDQDDLENL ILLKDEDRPD 120
  121 STQSCTKSSS EDSNLNGFEE YIREHGELVP GQTPPDGSHK CGVCPKSFSS ASGLKQHSHI 180
  181 HCSLKPFRCH LCPKSYTQFS NLCRHRRVHS DGWTCPTCQS QMPSQAALTK HRPVCEMTAL 240
  241 YKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.14649486810497 bayes_pls_golite062009
DNA binding 2.89992872665011 bayes_pls_golite062009
nucleic acid binding 2.66588130528088 bayes_pls_golite062009
transcription factor activity 1.97913234583912 bayes_pls_golite062009
binding 1.7678140110688 bayes_pls_golite062009
catalytic activity 0.616333600617445 bayes_pls_golite062009
transcription activator activity 0.35578487491271 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.29294316958168 bayes_pls_golite062009
protein binding 0.286371122239253 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [244-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMAQLAGLSG AGGLGSVPYW PHILQMATQA PHFPLAFLAA NPEAYKLMQQ TTCASPD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [301-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AECSSGHASE SSPTTTEPVD LTATPKPPST SEMETTSKSD DGEDRDSIGD SGNDDDDDSE  60
   61 AGVLDESSTT TSTKKRPTSH TISDILAAPQ LGAQALNSTF LGMLQRSLNY NPAVPSPHSF 120
  121 LRAMSGAKAS SSPSSSSGSG KDRYTCKFCQ KVFPRSANLT RHLRTHTGEQ PYKCQYCERS 180
  181 FSISSNLQRH VRNIHNKPNT SLTPHNHHRQ RSLHNSTSTS TTTTTVHHPL LHLPGTSVPV 240
  241 PKV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.045757
Match: 2i13A
Description: No description for 2i13A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle