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View Structure Prediction Details

Protein: mig-5
Organism: Caenorhabditis elegans
Length: 672 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mig-5.

Description E-value Query
Range
Subject
Range
mig-5 - presynaptic density protein (PSD-95) repeat-like domain status:Confirmed UniProt:O61720 protein_id:C...
348.0 [0..1] [622..1]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPPCTSDCS QIKVFYYLDD ETTPYVSVIE AREGVATLGN FKNSFTKRGY KYYAKELDPD  60
   61 IQREVKVELT TDSDRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.09691
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [77-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKSQNGFYEI FLVSTPGYGT LPRNSGTMTR PQRTALDKRR RRSADFDATP YSDASLAPST  60
   61 IVSRRAGEHL AELYTSNSED PYQYDEHTRR TGDDSSLYEP LAARDMNKIY DDDRRRKKQK 120
  121 KERFRRPYVP STISSATESS VNSGLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [223-345]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RILEIYLPMK NVPYLGLSVC TIDGHIFVSE IAPEGAVEKD GRVNVGDQIL QVNRVSFEEL  60
   61 SGPQAVRSLR EAASSKRPIT LYISKFARGA PSEYDDPLAS MASETMPLDV GVWVETAVQN 120
  121 TEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.221849
Match: 1lcyA
Description: Mitochondrial serine protease HtrA2; Mitochondrial serine protease HtrA2, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.72140630069624 bayes_pls_golite062009
protein binding 1.54045195100026 bayes_pls_golite062009
cytoskeletal protein binding 0.29313596416074 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [346-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALGLDPQE QTATTIDDGT LPFTSTASDD EERMLYDQRR NGIPRALIEE AERKRENEQN  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [406-510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKIEQLTEMI DPIIVVRSMA RPDSGLAVKN RKWLKILVPM SFIGRDLVDW LVDHMADIHN  60
   61 RKKARIYAAR LLAAGLIRHV VSKLTFTEKC YYVFGDGILG NDRNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1fshA
Description: Segment polarity protein Dishevelled-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.04426015975991 bayes_pls_golite062009
binding 1.99063774159045 bayes_pls_golite062009
DNA binding 1.63968725174405 bayes_pls_golite062009
nucleic acid binding 1.51035375793093 bayes_pls_golite062009
transcription factor activity 1.16072080355661 bayes_pls_golite062009
transcription activator activity 0.14130464856269 bayes_pls_golite062009
sequence-specific DNA binding 0.13573040816325 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [511-672]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDTTGTSGTT MRVEATTEVT YVGSPAPHAL AARVGRNIPH RLETTTLSPV AHDQTWLRRR  60
   61 RDCESPMTND YASMVGESQI GMNPVGNYHV FGTKNNHRQV PAPSQVTSSS LTNGSGGLGG 120
  121 PPPTPLSSTM VLAASPIQSQ NAVNHDFDGE NSSNSRTRIL RT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle