YRC Public Data Repository - Protein Structure Prediction

Protein:	rpia-1
Organism:	Caenorhabditis elegans
Length:	251 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rpia-1.

Description	E-value	Query Range	Subject Range
gi\|157774853 - gi\|157774853\|ref\|XP_001665492.1\| hypothetical protein CBG16597 [Caenorhabditis briggsae AF16] gi\|187026382, gi... - gi\|39594025\|emb\|CAE70135.1\| Hypothetical protein CBG16597 [Caenorhabditis briggsae], gi\|187026382\|em...	343.0	[0..1]	[251..1]
gi\|55250104, gi\|... - gi\|55925229\|ref\|NP_001007290.1\| ribose 5-phosphate isomerase A [Danio rerio], gi\|55250104\|gb\|AAH8554...	316.0	[0..15]	[244..43]
RPIA - ribose 5-phosphate isomerase A	311.0	[0..6]	[242..70]
ENSMMUT000000129... - null, null gi\|114578714 - gi\|114578714\|ref\|XP_525809.2\| PREDICTED: ribose 5-phosphate isomerase A (ribose 5-phosphate epimeras...	311.0	[0..6]	[242..70]
RPIA_MOUSE - Ribose-5-phosphate isomerase OS=Mus musculus GN=Rpia PE=1 SV=2	308.0	[0..3]	[247..60]
gi\|109473646, gi... - gi\|62647453\|ref\|XP_342708.2\| PREDICTED: similar to Ribose-5-phosphate isomerase (Phosphoriboisomeras...	307.0	[0..3]	[247..60]
gi\|18654317 - gi\|18654317\|gb\|AAL77589.1\|L43068_1 chloroplast ribose-5-phosphate isomerase [Spinacia oleracea]	306.0	[0..4]	[244..48]
RPIA_SYNEL - Ribose-5-phosphate isomerase A OS=Synechococcus elongatus GN=rpiA PE=3 SV=1 RPIA_THEEB - Ribose-5-phosphate isomerase A OS=Thermosynechococcus elongatus (strain BP-1) GN=rpiA PE=3 SV=1	304.0	[0..13]	[245..4]
RPIA_TRIEI - Ribose-5-phosphate isomerase A OS=Trichodesmium erythraeum (strain IMS101) GN=rpiA PE=3 SV=1	304.0	[0..1]	[239..1]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTSTGPEAE LAPIEQAKKR AAFACGEKYV QSGCRLGVGS GSTVKYLVEY LKQGFQNGSL  60
   61 KDIICVPTSF LTKQWLIESG LPVSDLDSHP ELDVCIDGAD EVDGQFTCIK GGGGCLAQEK 120
  121 IVQTAAKNFY VIADYLKDSK HLGDRYPNVP IEVLPLAAQP LLRSIPRAEG GSCQLRQAVK 180
  181 KCGPIVTDNG NFIIDWQFEK NVSGRDWFAI QQRLANTPGI VETGLFIGCV DAVFFAYSDG 240
  241 SVKEIVNSKK H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.69897
Match:	1lk5A
Description:	D-ribose-5-phosphate isomerase (RpiA), catalytic domain; D-ribose-5-phosphate isomerase (RpiA), lid domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribose-5-phosphate isomerase activity	2.78510459473943	bayes_pls_golite062009
intramolecular oxidoreductase activity	2.15381323621148	bayes_pls_golite062009
6-phosphogluconolactonase activity	1.97756803122763	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	1.65800801564277	bayes_pls_golite062009
catalytic activity	1.31732715713197	bayes_pls_golite062009
nucleic acid binding	1.15193795385115	bayes_pls_golite062009
binding	0.867979574569016	bayes_pls_golite062009
transcription regulator activity	0.527142798518238	bayes_pls_golite062009
DNA binding	0.465566131334457	bayes_pls_golite062009
glucosamine-6-phosphate deaminase activity	0.111185777194415	bayes_pls_golite062009
isomerase activity	0.102415560220489	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: