YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC18H10.07
Organism:	Schizosaccharomyces pombe
Length:	224 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC18H10.07.

Description	E-value	Query Range	Subject Range
gi\|73989056 - gi\|73989056\|ref\|XP_856888.1\| PREDICTED: similar to WW domain-containing binding protein 4 isoform 2 ...	130.0	[0..1]	[125..1]
WBP4_RAT - WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1	127.0	[0..1]	[122..1]
gi\|9055380, gi\|3... - ref\|NP_061235.1\| WW domain binding protein 4 [Mus musculus], gi\|3550077\|gb\|AAC34810.1\| formin bindi...	126.0	[0..1]	[122..1]
gi\|114651365 - gi\|114651365\|ref\|XP_509769.2\| PREDICTED: similar to formin binding protein 21 [Pan troglodytes]	126.0	[0..1]	[122..32]
gi\|33589798, gi\|... - gi\|33589798\|gb\|AAQ22665.1\| At1g49590 [Arabidopsis thaliana], gi\|15222782\|ref\|NP_175382.1\| formin-bin...	125.0	[0..1]	[110..1]
gi\|168279069 - gi\|168279069\|dbj\|BAG11414.1\| WW domain-binding protein 4 [synthetic construct] WBP4 - WW domain binding protein 4 (formin binding protein 21)	125.0	[0..1]	[122..1]
gi\|109120557 - gi\|109120557\|ref\|XP_001089623.1\| PREDICTED: similar to WW domain-containing binding protein 4 isofor...	125.0	[0..1]	[122..1]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADYWKSIPK YYCKYCQIFV KDTPFARRSH EQTYKHQDAI KKVMDDIHRS NLLRQELEKN  60
   61 LSIPKSATAT TASAVSSELA SYEKPKKEHP KLRPSKKKAT LDDWD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.39794
Match:	1uw2A
Description:	The structure of the zinc finger from the human spliceosomal protein U1C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.09159122181766	bayes_pls_golite062009
nucleic acid binding	2.00943575401579	bayes_pls_golite062009
DNA binding	1.88302925023035	bayes_pls_golite062009
transcription regulator activity	1.6938382526306	bayes_pls_golite062009
protein binding	1.34286017548503	bayes_pls_golite062009
transcription factor activity	0.811204561084531	bayes_pls_golite062009
chromatin binding	0.62560824382952	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.204179698114475	bayes_pls_golite062009
structure-specific DNA binding	0.142240538056721	bayes_pls_golite062009
double-stranded DNA binding	0.14032102345781	bayes_pls_golite062009
transcription activator activity	0.0726827112882662	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [106-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPTSSTETDT ISTTHTSYIP TLLAKQEENE ETKETTTNKN ESLPGTSLKR NREIIEKEER  60
   61 SSFHFRVKPK NLDKVPKLAE NEGNKSLESK ESNENKVVFK KKKSGKLRTK SSLKEYDQS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: