YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC19C2.13c
Organism:	Schizosaccharomyces pombe
Length:	366 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC19C2.13c.

Description	E-value	Query Range	Subject Range
CTU1_ORYSJ - Cytoplasmic tRNA 2-thiolation protein 1 OS=Oryza sativa subsp. japonica GN=NCS6 PE=2 SV=1	227.0	[0..11]	[327..17]
CTU1_ARATH - Cytoplasmic tRNA 2-thiolation protein 1 OS=Arabidopsis thaliana GN=NCS6 PE=2 SV=2	224.0	[0..1]	[327..1]
CTU1_XENTR - Cytoplasmic tRNA 2-thiolation protein 1 OS=Xenopus tropicalis GN=ctu1 PE=2 SV=1	218.0	[0..11]	[327..2]
CTU1_YEAST - Cytoplasmic tRNA 2-thiolation protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... NCS6 - Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; ha...	216.0	[0..3]	[327..11]
gi\|14520709, gi\|... - gi\|5457925\|emb\|CAB49415.1\| Predicted ATPase of the PP-loop superfamily [Pyrococcus abyssi GE5], gi\|1... gi\|7445410, gi\|5... - pir\|\|H75166 hypothetical protein PAB2029 - Pyrococcus abyssi (strain Orsay), gi\|5457925\|emb\|CAB49415...	216.0	[0..13]	[326..2]
CTU1_CAEBR - Cytoplasmic tRNA 2-thiolation protein 1 OS=Caenorhabditis briggsae GN=tut-1 PE=3 SV=1 gi\|157757853 - gi\|157757853\|ref\|XP_001671270.1\| Hypothetical protein CBG01646 [Caenorhabditis briggsae AF16]	216.0	[0..6]	[353..2]
CTU1_DANRE - Cytoplasmic tRNA 2-thiolation protein 1 OS=Danio rerio GN=ctu1 PE=2 SV=1	214.0	[0..11]	[327..2]
gi\|7430000 - pir\|\|H71048 hypothetical protein PH1680 - Pyrococcus horikoshii gi\|14591444, gi\|... - gi\|3258109\|dbj\|BAA30792.1\| 320aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14591444\|...	213.0	[0..13]	[326..2]

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Predicted Domain #1

Region A:
Residues: [1-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNTALDNSA DSKCSKCDNK ATVLTKSDAV CDSCFVRRIE NKIRRQFELV RPNLQGRKSK  60
   61 RAMLAISGGI SSMAMLETAN YLSKYRDDNY RPMFDELLAV HFQWGTDSAV AKTIEESISK 120
  121 NYPKCPFKVI GEAELLNRTI ATDSRGNIEI NADNEKFNPE VISSLASRQD LLYRIRDKLL 180
  181 VSYARKANCD TIVFGDSGTT IAARVLELVA EGRGFAIPWY TSVCSKLPNC DTFLLRPLRE 240
  241 VLSSDLKSYM NIKGLAFCDS LIEARPNTIH GVTESYFSSL NDTFPSLVST VVKMSSKLHV 300
  301 PSTEAICTIC NLPMQEDAET WLQKTTVEHP DSVEGIKNQN VCYGCSVSLK SLKGTLHIPD 360
  361 IEKEGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.522879
Match:	1gpmA
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity	3.71561290487771	bayes_pls_golite062009
DNA binding	0.992954560970173	bayes_pls_golite062009
nucleic acid binding	0.953721017285257	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
binding	0.752095595503409	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.724532065311415	bayes_pls_golite062009
transferase activity	0.0776944314618701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: