YRC Public Data Repository - Protein Structure Prediction

Protein:	klp8
Organism:	Schizosaccharomyces pombe
Length:	511 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for klp8.

Description	E-value	Query Range	Subject Range
gi\|50260460, gi\|... - gi\|50260460\|gb\|EAL23117.1\| hypothetical protein CNBA6420 [Cryptococcus neoformans var. neoformans B-...	374.0	[0..1]	[490..1]
gi\|67901120, gi\|... - gi\|67901120\|ref\|XP_680816.1\| hypothetical protein AN7547.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	374.0	[0..4]	[511..7]
gi\|109487521 - gi\|109487521\|ref\|XP_001070053.1\| PREDICTED: similar to Kinesin-like protein KIF1A (Axonal transporte...	370.0	[0..1]	[510..1]
gi\|159129862 - gi\|159129862\|gb\|EDP54976.1\| kinesin family protein [Aspergillus fumigatus A1163] gi\|71002248, gi\|... - gi\|71002248\|ref\|XP_755805.1\| kinesin family protein [Aspergillus fumigatus Af293], gi\|66853443\|gb\|EA...	369.0	[0..4]	[511..7]
gi\|157170176 - gi\|157170176\|gb\|AAI52808.1\| Kinesin family member 1B [synthetic construct] gi\|123209319, gi... - gi\|86990460\|ref\|NP_997565.2\| kinesin family member 1B isoform b [Mus musculus], gi\|187465979\|emb\|CAQ...	367.0	[0..1]	[510..1]
gi\|84627460 - gi\|84627460\|gb\|AAI11781.1\| Kinesin family member 1A [Homo sapiens]	366.0	[0..1]	[510..1]

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Predicted Domain #1

Region A:
Residues: [1-363]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTANVRVIV RVRPKSLREL SKSAEDLLSV DSHNKTVTIT PPKHGLKHSR HKNRVNGPRT  60
   61 FAFDECFAPS APESKNLSGQ EDVYESTGPL LVKSILEGFN SCFITYGQKG TGKTYSVVGL 120
  121 RGQPGIIPHI SESIFEEIDK LKKKSPNTTI TVSISLAEII EETPYDLLQP NVNSSHTPGE 180
  181 TVFVQKDSLT GYHLHGLSEF EVGSAQEIDA FLRLAAKNIR TELSDISGVR KGHSVFSLVV 240
  241 QQRIIDPKTR HSLKKASRLQ IIDLASFSKG SQRNESISSF ESSSNNKSLS VLNRVIAALT 300
  301 SKKNDVLIPY KDSVLTTLLQ DALGGNCRTI MLTCVSPCDF DDTFSALRYS EAARRIKNIS 360
  361 NIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	86.0
Match:	1i5sA
Description:	Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
microtubule motor activity	7.68336791348661	bayes_pls_golite062009
plus-end-directed microtubule motor activity	4.97507344344589	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.69246499202248	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
pyrophosphatase activity	2.61582393123755	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.59641929642359	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.59333672868803	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
binding	2.4974940028864	bayes_pls_golite062009
transporter activity	2.17383908004663	bayes_pls_golite062009
ATPase activity	2.11122403732968	bayes_pls_golite062009
transmembrane transporter activity	2.02444700826552	bayes_pls_golite062009
ATPase activity, coupled	1.8908019270286	bayes_pls_golite062009
cytoskeletal protein binding	1.50574672650697	bayes_pls_golite062009
hydrolase activity	1.35268825531078	bayes_pls_golite062009
substrate-specific transporter activity	0.97700154207756	bayes_pls_golite062009
actin binding	0.875514430441177	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.608058786636536	bayes_pls_golite062009
microfilament motor activity	0.2911562221251	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
ATP binding	0.19169045543599	bayes_pls_golite062009
adenyl ribonucleotide binding	0.165732470448462	bayes_pls_golite062009
adenyl nucleotide binding	0.162060759063149	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
ion transmembrane transporter activity	0.081265446432119	bayes_pls_golite062009
DNA binding	0.0759947537748353	bayes_pls_golite062009
minus-end-directed microtubule motor activity	0.068779631341469	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [364-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CKEAYSTNNE GELDDILTTL ESDREQLRRH EEHSQKLLKF IEEIRNDYEE RIHALESQNS  60
   61 ALKAHLRLAV DAYLNPLEFN FDDKNVKLKE FGSPNIAYKQ ELNSFQGELS SLFKDLKLVK 120
  121 SQLHDYPKPE VSDIDMDMES LRHDSLLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.522879
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: