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View Structure Prediction Details

Protein: vps8
Organism: Schizosaccharomyces pombe
Length: 1272 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vps8.

Description E-value Query
Range
Subject
Range
gi|82959089, gi|... - gi|94401064|ref|XP_999615.1| PREDICTED: similar to CG10144-PA isoform 9 [Mus musculus], gi|82964824|...
925.0 [0..29] [1185..93]
gi|109493499, gi... - gi|109494639|ref|XP_001058757.1| PREDICTED: similar to CG10144-PA [Rattus norvegicus], gi|109493499|...
922.0 [0..29] [1185..93]
gi|57863277, gi|... - gi|57863277|ref|NP_001009921.1| vacuolar protein sorting 8 homolog isoform a [Homo sapiens], gi|2234...
910.0 [0..29] [1185..93]
gi|109042371, gi... - gi|109042371|ref|XP_001097319.1| PREDICTED: similar to CG10144-PA isoform 6 [Macaca mulatta], gi|109...
903.0 [0..29] [1185..93]
gi|74003401 - gi|74003401|ref|XP_849791.1| PREDICTED: similar to CG10144-PA isoform 2 [Canis familiaris]
903.0 [0..29] [1185..93]

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Predicted Domain #1
Region A:
Residues: [1-541]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSKYGRSSL KIKNGDDTRT LRALSFSKDS VNSSSFDNEA ASTTLGISTA IHASNRPFRQ  60
   61 DEYSWNDCWM RWGQLRRVSS QLRELRFTMN DQPATVTSIA YQGTLLVAGT SSGHVLLNDW 120
  121 RTNDFQILKP GLSSNESVTL PVTSLAISNS KRIVCQGHAG GIIFVWDVSR KPPLQLFTIN 180
  181 QHSEDSVLTH LVFNGNSDDV LLSTDHLGKI AVHEFYNLVI NKHCTSWNLD MSKSNSLNLD 240
  241 SIIVDTSSIS FEELHITGVK HFSFVVLQSL QSIQIVTLFP KTTLIYEFKY PAGIVSSACH 300
  301 SFSSSIVHKN GENTKLHAFF ATAYNNNLRL YSVTFHKGYM SLQLMDRKKF AKAIWKLWWF 360
  361 PSSSIIIILF DDMELAFVNS MSLDIIGTST ILDKSLLRWD WYSNSLAAIG VSQTVFPFIS 420
  421 SSLCISPRYM FVVNSETVSV GSFLMVSEQL QMLSERYGFF DSIKFGSYCV SNLSIFPKLL 480
  481 LEKTSVINLI MALYVKLLKS LARDFPARSP FEATSQKTND YELEVQHLFT WTCELYSENF 540
  541 N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.39794
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 2.77599521858855 bayes_pls_golite062009
small conjugating protein ligase activity 2.52062758665339 bayes_pls_golite062009
acid-amino acid ligase activity 1.6726520555114 bayes_pls_golite062009
protein binding 1.61720914342874 bayes_pls_golite062009
binding 1.40353148474598 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.734230328744066 bayes_pls_golite062009
nucleic acid binding 0.110806113669931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [542-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVISSFIIAN SLGILPEIIE QIIPVFTRVG KVYVVLEALF DLILSQRFTN PSPQLQHHIL  60
   61 NYLNDCKRLQ DMDKLIPCIE YQSLDLDFIT KFSRSKGLFD SLCYVSIYAF NDYSIPLVQF 120
  121 LNLLKSDIDS PSEETSINVE KGFHFLLYSL TGM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [695-811]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYPLGHSNNI NDAYVVIHTL LKVIFSVVPL PFDVPVDNSV DFPYLRLFLE KHADDFFRCL  60
   61 EVAFDYPYFS LEKVTIAKKL LDTVNRQWIL ECISQLYEKK KSVSQSYYIF VSHVTAN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [812-1169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSNQLLFSQS FYQGILDGLC NIDVPDDKRE VVEAAIEELL TVYEHFDIAT TLLSCWDHQL  60
   61 YQVILHISFK CGRYEDYIEA ILALWKQKGQ KHSFVSESSE ALISLVFNNL QTINRFPGHR 120
  121 ERYVSTLISH CGDLFAINHV CFVRNSLKYL LDDFTKVITK TFSIKSIRLQ FLSLIIYEIT 180
  181 YEQLSSWYRE RTILSFLELV SFDQGDVKML ELLRLHPKLV RLQGLMEILN KNDCIESCIF 240
  241 VYRELAEYKL ALSHVSKYIE KSMSVFDLEK SDDMTSRRIE RLCLHLKTVV PLFEQCTKEV 300
  301 SAEDVTNFWL ELVFTLLLVY IKLSLKGSIN SQITFKDFQQ ELSLCIENLL DSFLSKTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1xi4A
Description: Clathrin D6 Coat
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1170-1272]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYKIALNTVL VRICEEASRN EHSDQYLRKL LLKLITDLYI NHDITKECFL LWDMKQFYEI  60
   61 RSTLLQNASG VLVEDPKLQK NAKGQYTSKL KVYFSGLIER EDL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.839 0.002 protein ubiquitination a.130.1 Chorismate mutase II


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle