YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC977.17
Organism:	Schizosaccharomyces pombe
Length:	598 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC977.17.

Description	E-value	Query Range	Subject Range
gi\|151944919 - gi\|151944919\|gb\|EDN63174.1\| conserved protein [Saccharomyces cerevisiae YJM789] YFL054C - Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the prese... YFF4_YEAST - Uncharacterized membrane protein YFL054C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	407.0	[0..56]	[589..92]
gi\|67901262, gi\|... - gi\|67901262\|ref\|XP_680887.1\| hypothetical protein AN7618.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	356.0	[0..86]	[563..86]
gi\|46115876, gi\|... - gi\|46115876\|ref\|XP_383956.1\| hypothetical protein FG03780.1 [Gibberella zeae PH-1], gi\|42548629\|gb\|E...	285.0	[0..102]	[575..108]
aqp-3 - Major intrinsic protein status:Partially_confirmed UniProt:Q9XW36 protein_id:CAA22259.1	281.0	[0..201]	[590..14]
gi\|39593674, gi\|... - gi\|39593674\|emb\|CAE61966.1\| Hypothetical protein CBG05966 [Caenorhabditis briggsae], gi\|187034571\|em... gi\|157756047 - gi\|157756047\|ref\|XP_001670367.1\| Hypothetical protein CBG05966 [Caenorhabditis briggsae AF16]	278.0	[0..201]	[590..14]
gi\|21536709 - gi\|21536709\|gb\|AAM61041.1\| aquaporin (plasma membrane intrinsic protein 1B) [Arabidopsis thaliana]	266.0	[0..247]	[556..1]
gi\|116311126, gi... - gi\|125549323\|gb\|EAY95145.1\| hypothetical protein OsI_16963 [Oryza sativa Indica Group], gi\|116311126... PIP12_ORYSJ - Probable aquaporin PIP1-2 OS=Oryza sativa subsp. japonica GN=PIP1-2 PE=2 SV=3	265.0	[0..247]	[556..1]
gi\|113565112, gi... - gi\|115459882\|ref\|NP_001053541.1\| Os04g0559700 [Oryza sativa (japonica cultivar-group)], gi\|113565112...	264.0	[0..247]	[556..1]
PIP12_MAIZE - Aquaporin PIP1-2 OS=Zea mays GN=PIP1-2 PE=1 SV=1	264.0	[0..247]	[556..1]
gi\|3551131 - gi\|3551131\|dbj\|BAA32777.1\| plasma membrane aquaporin (PAQ1) [Raphanus sativus]	264.0	[0..247]	[556..1]

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Predicted Domain #1

Region A:
Residues: [1-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPLRFSTP SSSPSASDNE SVHDDGPTTE LDTFNTTDVP RRVNTTKARQ MRPKNTLKVA  60
   61 FSSPNLKGLD NTADSDSQPW LGGYLAGRLE DISGQSRRNY VDPYYEELNA GRRPNKPVWS 120
  121 LNGPLPHVLG NSVVEKISQK NQEARSRANS RVNSRANSRA NSSVSLAGMD GSPNWKRKMK 180
  181 SAVFGSRVKL NDEEAQLPRN KSSVSIAEQA ASRPKVSFSL QSSRQPSIAE EQPQTQRKSS 240
  241 AITVEHAENA EPETPRNNVS FSRKPSIAEQ DSSQDITMPP NEIIAEESLD SGSDTETLY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [300-598]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNYWCKIRHF FREGFAEFLG TLVLVVFGVG SNLQATVTNG AGGSFESLSF AWGFGCMLGV  60
   61 YIAGGISGGH VNPAVTISLA IFRKFPWYKV PIYIFFQIWG AFFGGALAYG YHWSSITEFE 120
  121 GGKDIRTPAT GGCLYTNPKP YVTWRNAFFD EFIGTAVLVG CLFAILDDTN SPPTQGMTAF 180
  181 IVGLLIAAIG MALGYQTSFT LNPARDLGPR MFAWWIGYGP HSFHLYHWWW TWGAWGGTIG 240
  241 GGIAGGLIYD LVIFTGPESP LNYPDNGFID KKVHQITAKF EKEEEVENLE KTDSPIENN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.221849
Match:	1fx8A
Description:	Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	5.23077472964938	bayes_pls_golite062009
substrate-specific channel activity	5.0695479460357	bayes_pls_golite062009
substrate-specific transporter activity	5.06520190871345	bayes_pls_golite062009
passive transmembrane transporter activity	5.06054430984045	bayes_pls_golite062009
channel activity	5.06054430984045	bayes_pls_golite062009
transmembrane transporter activity	4.83314424546299	bayes_pls_golite062009
water transmembrane transporter activity	4.18721425448341	bayes_pls_golite062009
water channel activity	4.02651838773673	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.82456291801633	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.820388351311438	bayes_pls_golite062009
polyol transmembrane transporter activity	0.820388351311438	bayes_pls_golite062009
binding	0.629257163572322	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.545299611300918	bayes_pls_golite062009
ion transmembrane transporter activity	0.516648340085278	bayes_pls_golite062009
active transmembrane transporter activity	0.315342449421593	bayes_pls_golite062009
cation transmembrane transporter activity	0.141210715822635	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.0368961725897963	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: