YRC Public Data Repository - Protein Structure Prediction

Protein:	tps2
Organism:	Schizosaccharomyces pombe
Length:	849 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tps2.

Description	E-value	Query Range	Subject Range
gi\|39942722, gi\|... - gi\|39942722\|ref\|XP_360898.1\| hypothetical protein MG03441.4 [Magnaporthe grisea 70-15], gb\|EAA51846....	540.0	[0..8]	[849..333]
gi\|42554455, gi\|... - gi\|46127097\|ref\|XP_388102.1\| hypothetical protein FG07926.1 [Gibberella zeae PH-1], gi\|42554455\|gb\|E...	529.0	[0..8]	[849..27]
gi\|32407797, gi\|... - gi\|32407797\|ref\|XP_324398.1\| hypothetical protein [Neurospora crassa], gi\|28917409\|gb\|EAA27113.1\| hy... gi\|85079428 - gi\|85079428\|ref\|XP_956349.1\| hypothetical protein NCU05041 [Neurospora crassa OR74A]	524.0	[0..9]	[845..135]
gi\|114189402, gi... - gi\|115402959\|ref\|XP_001217556.1\| hypothetical protein ATEG_08970 [Aspergillus terreus NIH2624], gi\|1...	507.0	[0..6]	[849..104]
gi\|90307062, gi\|... - gi\|90307062\|gb\|EAS36693.1\| trehalose-phosphatase [Coccidioides immitis RS], gi\|119195345\|ref\|XP_0012...	506.0	[0..10]	[849..107]
gi\|169779902 - gi\|169779902\|ref\|XP_001824415.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83773155 - gi\|83773155\|dbj\|BAE63282.1\| unnamed protein product [Aspergillus oryzae]	501.0	[0..6]	[849..45]
gi\|71000709, gi\|... - gi\|71000709\|ref\|XP_755036.1\| alpha,alpha-trehalose-phosphate synthase subunit Tps2 [Aspergillus fumi... gi\|159128050 - gi\|159128050\|gb\|EDP53165.1\| alpha,alpha-trehalose-phosphate synthase subunit TPS2, putative [Aspergi...	499.0	[0..9]	[815..115]
gi\|34391866 - gi\|34391866\|gb\|AAO72737.1\| trehalose-6-phosphate phosphatase [Emericella nidulans]	490.0	[0..11]	[774..81]
TPS2 - Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the... TPS2_YEAST - Trehalose-phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPS2 PE=1 SV=3	490.0	[0..1]	[849..1]

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Predicted Domain #1

Region A:
Residues: [1-560]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSGAQGNTQ SAAYKRIVNV SRNFQFKAAL NKDTREWTFQ HRSSGTALYS AIASLGDPSS  60
   61 PWDAVYVASP GPVQISEGND HTVETKIDEA AVVHRSSSIV ISPEDQEIFL KKATEYYRKK 120
  121 NIEADIVPVW GKVQRVPQAK SSSATITPSV SNKLSTAYQS IKSEALKDGP MYADSVLWDV 180
  181 LHYRIPTLDG YQQHNLWKNF TRWSQYFADN IVSNYRPGDL ILIHDYSLFL LPRLIRKQLS 240
  241 DAPIVFFLHA PFCTSEVFRC LSKRAEILKG VLASNVIAMQ TDSYTRHFLS TCSNVLGLET 300
  301 TSTHIDTSDG FRVVVFSSHV SIDVPRVYSR CNSKPVSLKI QQLKSLYPSD KKLIVGRDQL 360
  361 TKACGVTHKL RAFRELLIHF PKWRGHVVLI QITSLPVGNN YSNEELKKTE NLVAQINSEF 420
  421 GSLDYTPVIH FHQLLDPDEY YALLSVANIA CVSSVRDSMN TMALEYVACQ QKNKGSLILS 480
  481 EFSGTAELLL SAYLVNPYDY SRFAETINYC LNMTEKERER RFSSLWKQAT SQSSQQWIYK 540
  541 LINRAAYEVK ALESHMTTPL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	67.154902
Match:	1uqtA
Description:	Trehalose-6-phosphate from E. coli bound with UDP-2-fluoro glucose.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	11.2045941324603	bayes_pls_golite062009
glucosyltransferase activity	8.25064561355471	bayes_pls_golite062009
UDP-glucosyltransferase activity	8.0463972704113	bayes_pls_golite062009
trehalose-phosphatase activity	7.58500038184065	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	3.70184884300914	bayes_pls_golite062009
catalytic activity	2.65148466065976	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.62403914335522	bayes_pls_golite062009
transferase activity	2.18054407163329	bayes_pls_golite062009
UDP-glycosyltransferase activity	2.13085705769565	bayes_pls_golite062009
binding	0.86799881302731	bayes_pls_golite062009
carbohydrate phosphatase activity	0.78952375993773	bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity	0.690032302126686	bayes_pls_golite062009
glycogen phosphorylase activity	0.607220464589157	bayes_pls_golite062009
phosphorylase activity	0.296436712681472	bayes_pls_golite062009
mannosyltransferase activity	0.253888301381021	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [561-849]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTYNILIKPY RNAKRRLFLL DYDGTLIESA RNSIDAVPTD RLLRTLKRLA SDSRNIVWIL  60
   61 SGRSQKFMEE WMGDISELGL SSEHGSAIRP PLAGSWSSCA ENLDLSWKDT VRDFFQYYVE 120
  121 RTPGSYIEEK KHSISWCYQN ANTTYSKFQS LECQTNLEDM LKHYDVEISP AKSFLEVHPN 180
  181 YLNKGSIVRR ILKRSGSVDF VFCAGDDKTD ENMFEVFLPT AFSNSHLIDE IDSTEYSGSH 240
  241 HTDDNSDANK VENVKVATFR VHIGLTDKPT LSDYHLPAPR DLGELLHNL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.522879
Match:	1rkqA
Description:	Crystal structure of NYSGRC target T1436: A Hypothetical protein yidA.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
trehalose-phosphatase activity	3.78859922218487	bayes_pls_golite062009
catalytic activity	1.55296860681783	bayes_pls_golite062009
binding	0.54369553186176	bayes_pls_golite062009
hydrolase activity	0.385402333062566	bayes_pls_golite062009
nucleic acid binding	0.263520144636139	bayes_pls_golite062009
phosphatase activity	0.159899259988948	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.103902756538853	bayes_pls_golite062009
DNA binding	0.0142681844140111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: