YRC Public Data Repository - Protein Structure Prediction

Protein:	gua2
Organism:	Schizosaccharomyces pombe
Length:	539 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gua2.

Description	E-value	Query Range	Subject Range
gi\|221089178, gi... - gi\|221089178\|ref\|ZP_03558700.1\| GMP synthase, large subunit [Geobacillus sp. Y412MC61], gi\|220706876... GUAA_GEOKA - GMP synthase [glutamine-hydrolyzing] OS=Geobacillus kaustophilus GN=guaA PE=3 SV=1 gi\|229328416, gi... - gi\|229500698\|ref\|ZP_04394346.1\| GMP synthase, large subunit [Geobacillus sp. Y412MC52], gi\|229328416... GUAA_GEOKA - GMP synthase [glutamine-hydrolyzing] OS=Geobacillus kaustophilus (strain HTA426) GN=guaA PE=3 SV=1	495.0	[0..20]	[539..5]
GUAA_BACLD - GMP synthase [glutamine-hydrolyzing] OS=Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 250...	494.0	[0..14]	[539..2]
GUAA_MOOTA - GMP synthase [glutamine-hydrolyzing] OS=Moorella thermoacetica (strain ATCC 39073) GN=guaA PE=3 SV=1	491.0	[0..21]	[539..12]
GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1 GUAA_SALTY - GMP synthase [glutamine-hydrolyzing] OS=Salmonella typhimurium GN=guaA PE=3 SV=1	491.0	[0..14]	[539..3]
GUAA_SHIB3 - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	491.0	[0..14]	[539..3]
GUAA_SHISS - GMP synthase [glutamine-hydrolyzing] OS=Shigella sonnei (strain Ss046) GN=guaA PE=3 SV=1	490.0	[0..14]	[539..3]
GUAA_SHIF8 - GMP synthase [glutamine-hydrolyzing] OS=Shigella flexneri serotype 5b (strain 8401) GN=guaA PE=3 SV=...	490.0	[0..14]	[539..3]
GUAA_SHIBS - GMP synthase [glutamine-hydrolyzing] OS=Shigella boydii serotype 4 (strain Sb227) GN=guaA PE=3 SV=1	490.0	[0..14]	[539..3]
gi\|24113836, gi\|... - gi\|24113836\|ref\|NP_708346.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Shigella ... gi\|30042154, gi\|... - gi\|30063899\|ref\|NP_838070.1\| bifunctional GMP synthase/glutamine amidotransferase protein [Shigella ... GUAA_SHIFL - GMP synthase [glutamine-hydrolyzing] OS=Shigella flexneri GN=guaA PE=3 SV=1	490.0	[0..14]	[539..3]
GUAA_ECO24 - GMP synthase [glutamine-hydrolyzing] OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=guaA PE...	490.0	[0..14]	[539..3]

Back

Predicted Domain #1

Region A:
Residues: [1-539]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSTEVPGEV STSVSSYFDT ILILDFGSQY SHLIARRLRE IHVYAELLPC TQKIEALPFK  60
   61 PIGVILSGGP YSVYDDIAPH VDPAVFELGV PVLGICYGMQ EIAWLNGRCV EPGIEREYGP 120
  121 ATVSMEPEIK TEVFKSFFNS MPKEFEVWMS HGDRLSALPN GYETIGRTKN SPFAVIAHVT 180
  181 KPIIGLQFHP EVTHTPLGLQ LIKNFAIEIC HAKPNWSMEN FVDKEILRIR KMIGPSDHVI 240
  241 GAVSGGVDST VASKVLKEAI GDRFHAIMVD NGLLRLNEAE IVRETLNKHL GIQLTVVDAS 300
  301 EEFIGKLKGV TDPEKKRKII GNTFIHVFER EAERIVKETN GKVEYLLQGT LYPDVIESIS 360
  361 FKGPSQTIKT HHNVGGLLKD MKLKLIEPLR ELFKDEVRAL GELLGIEHSL VWRHPFPGPG 420
  421 LGIRILGEVN AAQLEIARKA DHIFITEIRN HGYYDKISQA FAALLPVKAV GVMGDKRTHE 480
  481 QVIALRAITT SDFMTADWYD GFSIKFLKLV SSRICNEVSG VNRVLYDISS KPPATVEME

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	139.0
Match:	1gpmA
Description:	GMP synthetase; GMP synthetase, central domain; GMP synthetase C-terminal dimerisation domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	2.70451256281397	bayes_pls_golite062009
anthranilate synthase activity	2.51214170411838	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.33781404450996	bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity	1.83575136996743	bayes_pls_golite062009
carbamoyl-phosphate synthase activity	1.74828881793189	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	1.74029540439985	bayes_pls_golite062009
ligase activity	1.70348758031146	bayes_pls_golite062009
oxo-acid-lyase activity	1.35896725827905	bayes_pls_golite062009
catalytic activity	1.30391542469987	bayes_pls_golite062009
GMP synthase activity	0.413068109408727	bayes_pls_golite062009
asparagine synthase (glutamine-hydrolyzing) activity	0.3673193848392	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.270391651600004	bayes_pls_golite062009
carbon-carbon lyase activity	0.0769356405014503	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: