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View Structure Prediction Details

Protein: twf1
Organism: Schizosaccharomyces pombe
Length: 328 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for twf1.

Description E-value Query
Range
Subject
Range
gi|54673670, gi|... - gi|54673670|gb|AAH43148.2| Twinfilin, actin-binding protein, homolog 1 (Drosophila) [Homo sapiens], ...
gi|190690019, gi... - gi|190691391|gb|ACE87470.1| twinfilin, actin-binding protein, homolog 1 (Drosophila) protein [synthe...
345.0 [0..1] [328..35]
TWF2_MOUSE - Twinfilin-2 OS=Mus musculus GN=Twf2 PE=1 SV=1
gi|117616970, gi... - gi|117617016|gb|ABK42526.1| SGK396 [synthetic construct], gi|117616970|gb|ABK42503.1| A6r [synthetic...
344.0 [0..1] [328..1]
gi|149018687, gi... - gi|207028435|ref|NP_001128710.1| hypothetical protein LOC684352 [Rattus norvegicus], gi|165971615|gb...
343.0 [0..1] [328..1]
gi|114645198 - gi|114645198|ref|XP_001165727.1| PREDICTED: twinfilin isoform 5 [Pan troglodytes]
342.0 [0..1] [328..35]
gi|61368434, gi|... - gi|61368434|gb|AAX43179.1| PTK9 protein tyrosine kinase 9 [synthetic construct], gi|60828062|gb|AAX3...
341.0 [0..1] [328..1]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASVELKPT EKFSKFLEEY SSVPVRAAII SISNENSFDV KTMVEKSESI ESDFKKVREC  60
   61 LLGSEEPAFV LVYDDSKKNL LQLISYVPEN ANVRRKMLYA SSRAAFVRCV TLAKLDESYF 120
  121 ASTPEELDYQ QIMKSLSKQE DQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.221849
Match: 1m4jA
Description: Adf-H domain of twinfilin isoform-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.52071741004022 bayes_pls_golite062009
cytoskeletal protein binding 6.04859625643932 bayes_pls_golite062009
actin filament binding 5.45532510538573 bayes_pls_golite062009
binding 2.41877859618486 bayes_pls_golite062009
protein kinase activity 2.22634235673758 bayes_pls_golite062009
protein binding 1.87981807141519 bayes_pls_golite062009
protein tyrosine kinase activity 1.87091423399482 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.67227267699496 bayes_pls_golite062009
kinase activity 1.55883505515498 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.3406661967545 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.30213296029859 bayes_pls_golite062009
molecular transducer activity 1.14209355225632 bayes_pls_golite062009
signal transducer activity 1.14209355225632 bayes_pls_golite062009
transferase activity 0.591259446255369 bayes_pls_golite062009
structural constituent of cytoskeleton 0.482954032096802 bayes_pls_golite062009
structural molecule activity 0.391701411061931 bayes_pls_golite062009
actin monomer binding 0.224304003054399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [143-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLRQDELER KEYNESMQSS VTHKRPLVTR GVAMSIDDKA LKALSDLKSS TENNLVILSI  60
   61 DKEVISLSQE KQNIPPSDVK SFFSSTEPNF AFYSLPKDGS SKILFIYICP MQATVKHRMV 120
  121 YSSSKLGLLD SIKAELGIVI DGKIESNDAA DITEKEILHA AGISSPQAET STTKTGFSRP 180
  181 RPPRRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.09691
Match: 1cfyA
Description: Cofilin (actin depolymerizing factor, ADF)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.52071741004022 bayes_pls_golite062009
cytoskeletal protein binding 6.04859625643932 bayes_pls_golite062009
actin filament binding 5.45532510538573 bayes_pls_golite062009
binding 2.41877859618486 bayes_pls_golite062009
protein kinase activity 2.22634235673758 bayes_pls_golite062009
protein binding 1.87981807141519 bayes_pls_golite062009
protein tyrosine kinase activity 1.87091423399482 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.67227267699496 bayes_pls_golite062009
kinase activity 1.55883505515498 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.3406661967545 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.30213296029859 bayes_pls_golite062009
molecular transducer activity 1.14209355225632 bayes_pls_golite062009
signal transducer activity 1.14209355225632 bayes_pls_golite062009
transferase activity 0.591259446255369 bayes_pls_golite062009
structural constituent of cytoskeleton 0.482954032096802 bayes_pls_golite062009
structural molecule activity 0.391701411061931 bayes_pls_golite062009
actin monomer binding 0.224304003054399 bayes_pls_golite062009

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