Protein Overview: twf1

General Information:
Name(s) found:	twf1 / SPCC126.06 [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	twinfilin [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	328 amino acids
Gene Ontology:
Cellular Component:	cell division site [IDA] cell tip [IDA] actin cortical patch [ISS]
Biological Process:	sequestering of actin monomers [ISS] actin cortical patch localization [NAS]
Molecular Function:	actin monomer binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASVELKPT EKFSKFLEEY SSVPVRAAII SISNENSFDV KTMVEKSESI ESDFKKVREC  60
   61 LLGSEEPAFV LVYDDSKKNL LQLISYVPEN ANVRRKMLYA SSRAAFVRCV TLAKLDESYF 120
  121 ASTPEELDYQ QIMKSLSKQE DQSPLRQDEL ERKEYNESMQ SSVTHKRPLV TRGVAMSIDD 180
  181 KALKALSDLK SSTENNLVIL SIDKEVISLS QEKQNIPPSD VKSFFSSTEP NFAFYSLPKD 240
  241 GSSKILFIYI CPMQATVKHR MVYSSSKLGL LDSIKAELGI VIDGKIESND AADITEKEIL 300
  301 HAAGISSPQA ETSTTKTGFS RPRPPRRR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..142]	PSI-BLAST	40.221849	Adf-H domain of twinfilin isoform-1
2	View Details	[143..328]	PSI-BLAST	35.09691	Cofilin (actin depolymerizing factor, ADF)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
actin binding	7.52071741004022	bayes_pls_golite062009
cytoskeletal protein binding	6.04859625643932	bayes_pls_golite062009
actin filament binding	5.45532510538573	bayes_pls_golite062009
binding	2.41877859618486	bayes_pls_golite062009
protein kinase activity	2.22634235673758	bayes_pls_golite062009
protein binding	1.87981807141519	bayes_pls_golite062009
protein tyrosine kinase activity	1.87091423399482	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.67227267699496	bayes_pls_golite062009
kinase activity	1.55883505515498	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding	1.3406661967545	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.30213296029859	bayes_pls_golite062009
molecular transducer activity	1.14209355225632	bayes_pls_golite062009
signal transducer activity	1.14209355225632	bayes_pls_golite062009
transferase activity	0.591259446255369	bayes_pls_golite062009
structural constituent of cytoskeleton	0.482954032096802	bayes_pls_golite062009
structural molecule activity	0.391701411061931	bayes_pls_golite062009
actin monomer binding	0.224304003054399	bayes_pls_golite062009

2

Term	Confidence	Notes
actin binding	7.52071741004022	bayes_pls_golite062009
cytoskeletal protein binding	6.04859625643932	bayes_pls_golite062009
actin filament binding	5.45532510538573	bayes_pls_golite062009
binding	2.41877859618486	bayes_pls_golite062009
protein kinase activity	2.22634235673758	bayes_pls_golite062009
protein binding	1.87981807141519	bayes_pls_golite062009
protein tyrosine kinase activity	1.87091423399482	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.67227267699496	bayes_pls_golite062009
kinase activity	1.55883505515498	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding	1.3406661967545	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.30213296029859	bayes_pls_golite062009
molecular transducer activity	1.14209355225632	bayes_pls_golite062009
signal transducer activity	1.14209355225632	bayes_pls_golite062009
transferase activity	0.591259446255369	bayes_pls_golite062009
structural constituent of cytoskeleton	0.482954032096802	bayes_pls_golite062009
structural molecule activity	0.391701411061931	bayes_pls_golite062009
actin monomer binding	0.224304003054399	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle