YRC Public Data Repository - Protein Structure Prediction

Protein:	spt16
Organism:	Schizosaccharomyces pombe
Length:	1019 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for spt16.

Description	E-value	Query Range	Subject Range
gi\|238490099, gi... - gi\|238490099\|ref\|XP_002376287.1\| transcription elongation complex subunit (Cdc68) [Aspergillus flavu... SPT16_ASPOR - FACT complex subunit spt16 OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) GN=spt16 PE=3 SV=1 SPT16_ASPOR - FACT complex subunit spt16 OS=Aspergillus oryzae GN=spt16 PE=3 SV=1	1027.0	[0..2]	[1019..3]
SPT16_GIBZE - FACT complex subunit SPT16 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)... SPT16_GIBZE - FACT complex subunit SPT16 OS=Gibberella zeae GN=SPT16 PE=3 SV=1	1015.0	[0..1]	[1019..1]
dre4-PB - The gene dre4 is referred to in FlyBase by the symbol Dmel\dre4 (CG1828, FBgn0002183). It is a prote...	1009.0	[0..1]	[1017..1]
gi\|115385959, gi... - gi\|115385959\|ref\|XP_001209526.1\| hypothetical protein ATEG_10224 [Aspergillus terreus NIH2624], gi\|1...	1004.0	[0..1]	[1019..1]
SPT16_EMENI - FACT complex subunit spt16 OS=Emericella nidulans GN=spt16 PE=3 SV=1 gi\|67537864, gi\|... - gi\|67537864\|ref\|XP_662706.1\| hypothetical protein AN5102.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	1003.0	[0..3]	[1018..4]
gi\|62661343, gi\|... - gi\|62661343\|ref\|XP_223981.3\| PREDICTED: similar to suppressor of Ty 16 homolog [Rattus norvegicus], ...	1002.0	[0..4]	[1003..101]
SPT16_ASPFU - FACT complex subunit spt16 OS=Aspergillus fumigatus GN=spt16 PE=3 SV=1 SPT16_ASPFU - FACT complex subunit spt16 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC...	997.0	[0..2]	[1019..3]
gi\|76627095 - gi\|76627095\|ref\|XP_592917.2\| PREDICTED: similar to chromatin-specific transcription elongation facto...	994.0	[0..4]	[1003..3]
SUPT16H - suppressor of Ty 16 homolog (S. cerevisiae) gi\|114651875 - gi\|114651875\|ref\|XP_528703.2\| PREDICTED: similar to chromatin-specific transcription elongation fact... gi\|208967510 - gi\|208967510\|dbj\|BAG73769.1\| suppressor of Ty 16 homolog [synthetic construct]	994.0	[0..4]	[1003..3]

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Predicted Domain #1

Region A:
Residues: [1-440]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEYEIDEIT FHKRLGILLT SWKNEEDGKT LFQDCDSILV TVGAHDDTNP YQKSTALHTW  60
   61 LLGYEFPSTL ILLEKHRITI LTSVNKANML TKLAETKGAA ADVNILKRTK DAEENKKLFE 120
  121 KIIEYIRATN KKVGVFPKDK TQGKFINEWD SIFEPVKSEF NLVDASLGLA KCLAIKDEQE 180
  181 LANIKGASRV SVAVMSKYFV DELSTYIDQG KKITHSKFSD QMESLIDNEA FFQTKSLKLG 240
  241 DIDLDQLEWC YTPIIQSGGS YDLKPSAITD DRNLHGDVVL CSLGFRYKSY CSNVGRTYLF 300
  301 DPDSEQQKNY SFLVALQKKL FEYCRDGAVI GDIYTKILGL IRAKRPDLEP NFVRNLGAGI 360
  361 GIEFRESSLL VNAKNPRVLQ AGMTLNLSIG FGNLINPHPK NSQSKEYALL LIDTIQITRS 420
  421 DPIVFTDSPK AQGDISYFFG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	80.69897
Match:	1a16A
Description:	AMINOPEPTIDASE P FROM E. COLI WITH THE INHIBITOR PRO-LEU
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.3228898238998	bayes_pls_golite062009
DNA binding	1.6830709273154	bayes_pls_golite062009
nucleic acid binding	1.67660713848062	bayes_pls_golite062009
binding	1.4562583231987	bayes_pls_golite062009
transcription factor activity	1.02226978078776	bayes_pls_golite062009
protein binding	0.170797254754318	bayes_pls_golite062009
catalytic activity	0.148551873544128	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [441-525]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDSSLEDGV KPRKPPTRGT ATISSHKGKT RSETRDLDDS AEKRRVEHQK QLASRKQAEG  60
   61 LQRFAQGSVP SSGIEKPTVK RFESY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.532	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.730	a.47.2	t-snare proteins
View	Download	0.493	a.7.1	Spectrin repeat
View	Download	0.498	d.150.1	4'-phosphopantetheinyl transferase
View	Download	0.580	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac

Predicted Domain #3

Region A:
Residues: [526-644]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRDSQLPQAI GELRILVDYR AQSIILPIFG RPVPFHISTL KNASKNDEGN FVYLRLNFVS  60
   61 PGQIGGKKDE LPFEDPNAQF IRSFTFRSSN NSRMSQVFKD IQDMKKAATK RETERKEFA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	36.39794
Match:	PF08644.2
Description:	No description for PF08644.2 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.407	0.164	RNA elongation from RNA polymerase II promoter	a.25.1	Ferritin-like
View	Download	0.576	0.040	RNA elongation from RNA polymerase II promoter	a.47.2	t-snare proteins
View	Download	0.393	0.022	RNA elongation from RNA polymerase II promoter	a.24.9	alpha-catenin/vinculin
View	Download	0.398	0.005	RNA elongation from RNA polymerase II promoter	f.31.1	Photosystem I reaction center subunit XI, PsaL
View	Download	0.472	N/A	N/A	a.47.2	t-snare proteins

Predicted Domain #4

Region A:
Residues: [645-923]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVIEQDKLIE IKNKRPAHIN DVYVRPAIDG KRLPGFIEIH QNGIRYQSPL RSDSHIDLLF  60
   61 SNMKHLFFQP CEGELIVLIH VHLKAPIMVG KRKTQDVQFY REVSDIQFDE TGNKKRKYMY 120
  121 GDEDELEQEQ EERRRRAQLD REFKSFAEKI AEASEGRIEL DIPFRELAFN GVPFRSNVLL 180
  181 QPTTDCLVQL TDTPFTVITL NEIEIAHLER VQFGLKNFDL VFIFQDFRRP PIHINTIPME 240
  241 QLDNVKEWLD SCDICFYEGP LNLNWTTIMK TVNEDPIAF

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.965
Match:	2gcjA
Description:	No description for 2gcjA was found.

Predicted Domain #5

Region A:
Residues: [924-1019]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEEGGWGFLG APSDDEGDDS VEEVSEYEAS DADPSDEEEE ESEEYSEDAS EEDGYSESEV  60
   61 EDEESGEDWD ELERKARQED AKHDAFEERP SKKRHR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: