YRC Public Data Repository - Protein Structure Prediction

Protein:	mvd1
Organism:	Schizosaccharomyces pombe
Length:	393 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mvd1.

Description	E-value	Query Range	Subject Range
gi\|49077992, gi\|... - gi\|71022191\|ref\|XP_761326.1\| hypothetical protein UM05179.1 [Ustilago maydis 521], ref\|XP_402794.1\| ...	286.0	[0..1]	[387..1]
gi\|134115721, gi... - gi\|50256200\|gb\|EAL18927.1\| hypothetical protein CNBI1880 [Cryptococcus neoformans var. neoformans B-...	283.0	[0..5]	[391..2]
gi\|57230329, gi\|... - gi\|58261674\|ref\|XP_568247.1\| diphosphomevalonate decarboxylase [Cryptococcus neoformans var. neoform...	282.0	[0..5]	[391..2]
MVD1_RAT - Diphosphomevalonate decarboxylase OS=Rattus norvegicus GN=Mvd PE=1 SV=1	280.0	[0..7]	[388..10]
gi\|60655429, gi\|... - gi\|60655429\|gb\|AAX32278.1\| mevalonate (diphospho) decarboxylase [synthetic construct], gi\|124126813\|... MVD - mevalonate (diphospho) decarboxylase	278.0	[0..2]	[388..4]
gi\|30584105, gi\|... - gi\|61372632\|gb\|AAX43880.1\| mevalonate (diphospho) decarboxylase [synthetic construct], gi\|30584105\|g...	278.0	[0..2]	[388..4]
gi\|73956933 - gi\|73956933\|ref\|XP_546783.2\| PREDICTED: similar to Diphosphomevalonate decarboxylase (Mevalonate pyr...	277.0	[0..2]	[388..4]
gi\|74218080 - gi\|74218080\|dbj\|BAE42019.1\| unnamed protein product [Mus musculus]	276.0	[0..7]	[388..10]

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Predicted Domain #1

Region A:
Residues: [1-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKKVYQCTV SAPVNIAVIK YWGKRDVALN LPTNSSISVT LSQDDLRTVT TASCSEKFEN  60
   61 DTLWLNGNAE EIFANKRLRV CVEELRKARL DLEEENDDLD KIGALKLHVV SENNFPTAAG 120
  121 LASSAAGYAA FCEAIARLYD LPWTPTQLSR IARQGSGSAC RSLFGGYVAW EMGELHSGAD 180
  181 SVAVQVEPVE NWPEIRVAVL VASAAKKGVS STAGMQATVA SSTLFQHRIQ NIVPQRIQEM 240
  241 KTAIRERDFE TFAKLTMTDS NQFHACCLDT FPPIFYLNDT SRAVIRVVEN INATAGKTIA 300
  301 AYTFDAGPNA VIYFLEENSE IVLNTLYAVT KNAEGWSKQY GSSPVTVDSA AANIVSSGIS 360
  361 RVILTRVGNG PRVLTIDESL IDASGNPKFI GSH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.30103
Match:	1fi4A
Description:	Mevalonate 5-diphosphate decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
diphosphomevalonate decarboxylase activity	2.34245588421319	bayes_pls_golite062009
binding	1.48300512137561	bayes_pls_golite062009
catalytic activity	0.836142537655721	bayes_pls_golite062009
structural constituent of ribosome	0.66774567862554	bayes_pls_golite062009
carbohydrate kinase activity	0.49664490095304	bayes_pls_golite062009
structural molecule activity	0.40691892506083	bayes_pls_golite062009
nucleic acid binding	0.369771518688522	bayes_pls_golite062009
protein binding	0.214066724623027	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: