YRC Public Data Repository - Protein Structure Prediction

Protein:	cpd1
Organism:	Schizosaccharomyces pombe
Length:	364 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cpd1.

Description	E-value	Query Range	Subject Range
TRM61_CANAL - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida albicans (strain SC5314... TRM61_CANAL - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Candida albicans GN=TRM61 PE=3 SV=...	230.0	[0..1]	[354..1]
TRM61_YEAST - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Saccharomyces cerevisiae (strai... GCD14 - Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of...	212.0	[0..2]	[351..5]
TRM61_DEBHA - tRNA - Debaryomyces hansenii (Yeast) (Torulaspora hansenii) gi\|50413274, gi\|... - gi\|50413274\|ref\|XP_457237.1\| hypothetical protein DEHA0B06380g [Debaryomyces hansenii CBS767], gi\|49...	209.0	[0..1]	[352..1]
TRM61_ASHGO - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Ashbya gossypii (strain ATCC 10... TRM61_ASHGO - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Ashbya gossypii GN=TRM61 PE=3 SV=1	209.0	[0..1]	[351..1]
TRM61_CANGA - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Candida glabrata GN=TRM61 PE=3 SV=... TRM61_CANGA - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Candida glabrata (strain ATCC 2...	203.0	[0..3]	[360..5]
TRM61_KLULA - tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61 OS=Kluyveromyces lactis GN=TRM61 PE=3... TRM61_KLULA - tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 OS=Kluyveromyces lactis (strain AT...	198.0	[0..1]	[351..1]
gi\|71915941, gi\|... - gi\|72162209\|ref\|YP_289866.1\| tRNA (adenine-58-N(1)-) methyltransferase [Thermobifida fusca YX], gi\|7... gi\|48837251 - ref\|ZP_00294246.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyltransferases...	182.0	[0..7]	[302..8]
gi\|3790599 - gi\|3790599\|gb\|AAC68688.1\| unknown [Rhodococcus erythropolis]	181.0	[0..6]	[287..42]
gi\|27503341, gi\|... - gi\|27503341\|gb\|AAH42219.1\| MGC53312 protein [Xenopus laevis], gi\|148235755\|ref\|NP_001079426.1\| hypot...	180.0	[0..1]	[350..1]
gi\|31618890, gi\|... - gi\|31793298\|ref\|NP_855791.1\| RNA methyltransferase [Mycobacterium bovis AF2122/97], gi\|31618890\|emb\|... gi\|215403502 - gi\|215403502\|ref\|ZP_03415683.1\| RNA methyltransferase [Mycobacterium tuberculosis 02_1987] TRMI_MYCTU - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis GN=trmI PE=1 SV=1 TRMI_MYCTO - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshk... gi\|215427494 - gi\|215427494\|ref\|ZP_03425413.1\| RNA methyltransferase [Mycobacterium tuberculosis T92] TRMI_MYCTU - tRNA (adenine(58)-N(1))-methyltransferase TrmI OS=Mycobacterium tuberculosis (strain ATCC 25618 / H3... gi\|121493648, gi... - gi\|121638000\|ref\|YP_978224.1\| putative RNA methyltransferase [Mycobacterium bovis BCG str. Pasteur 1... gi\|215411822 - gi\|215411822\|ref\|ZP_03420614.1\| RNA methyltransferase [Mycobacterium tuberculosis 94_M4241A] gi\|194544330, gi... - gi\|81253912\|ref\|ZP_00878442.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyl... gi\|215446343 - gi\|215446343\|ref\|ZP_03433095.1\| RNA methyltransferase [Mycobacterium tuberculosis T85] gi\|215431042 - gi\|215431042\|ref\|ZP_03428961.1\| RNA methyltransferase [Mycobacterium tuberculosis EAS054] gi\|224773607, gi... - gi\|224990494\|ref\|YP_002645181.1\| putative RNA methyltransferase [Mycobacterium bovis BCG str. Tokyo ... gi\|218753840 - gi\|218753840\|ref\|ZP_03532636.1\| RNA methyltransferase [Mycobacterium tuberculosis GM 1503] gi\|253320323, gi... - gi\|253798820\|ref\|YP_003031821.1\| RNA methyltransferase [Mycobacterium tuberculosis KZN 1435], gi\|253... gi\|254551150 - gi\|254551150\|ref\|ZP_05141597.1\| RNA methyltransferase [Mycobacterium tuberculosis '98-R604 INH-RIF-E... gi\|254815934 - gi\|254815934\|ref\|ZP_05220935.1\| putative RNA methyltransferase [Mycobacterium tuberculosis KZN 4207] gi\|255096921 - gi\|255096921\|ref\|ZP_05326399.1\| putative RNA methyltransferase [Mycobacterium tuberculosis KZN 605] gi\|254364925, gi... - gi\|254364925\|ref\|ZP_04980971.1\| hypothetical RNA methyltransferase [Mycobacterium tuberculosis str. ... gi\|148661933, gi... - gi\|167967472\|ref\|ZP_02549749.1\| hypothetical RNA methyltransferase [Mycobacterium tuberculosis H37Ra... gi\|148721856, gi... - gi\|76784001\|ref\|ZP_00771188.1\| COG2519: tRNA(1-methyladenosine) methyltransferase and related methyl...	179.0	[0..8]	[286..5]

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Predicted Domain #1

Region A:
Residues: [1-364]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFADYKQRV ENGDLAVAWI GRNKLIPLHI EAEKTFHNQY GAFPHSEMIG KRYGEQIAST  60
   61 AKQGFIYLLQ PTPELWTLAL PHRTQIVYTP DIALIHQKLR ITYGTRVIEA GTGSASMSHA 120
  121 ISRTVGPLGR LFTFEYHATR YQTALQEFRE HEMLIDVGGN THLTHRDVCK DGFLDTEVKV 180
  181 DAIFLDLPAP WEAIPHLSNH VNHDKSTRIC CFSPCIEQIQ HSAEALRELG WCDIEMIEVD 240
  241 YKQWAARKSR IVHIDEAIDR LKEVKRRRIE GFERRKMRRE QNLSSDAKVE DQDNDSMLGE 300
  301 NKSSVSTETA LKPVTNKRIR EGDGNYEWTD VARVDSNLKS HTSYLLFAVH LPSQLDKQNQ 360
  361 ETGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.30103
Match:	2b25A
Description:	Human putative tRNA(1-methyladenosine)methyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tRNA (adenine)-methyltransferase activity	8.68185118956881	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	8.68185118956881	bayes_pls_golite062009
tRNA methyltransferase activity	7.81931840222208	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	7.024459985818	bayes_pls_golite062009
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
N-methyltransferase activity	4.07806017452628	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
protein methyltransferase activity	3.92746815303714	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.99461585647365	bayes_pls_golite062009
transferase activity	2.926540904444	bayes_pls_golite062009
arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.41876112831625	bayes_pls_golite062009
rRNA methyltransferase activity	2.29640050660273	bayes_pls_golite062009
DNA-methyltransferase activity	2.18991764495147	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	2.04296107639729	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.88889414729709	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.66871163498737	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	1.1103522853299	bayes_pls_golite062009
transcription regulator activity	0.914549843668268	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.89325812193225	bayes_pls_golite062009
DNA binding	0.86027591375666	bayes_pls_golite062009
binding	0.777596419415505	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
nucleic acid binding	0.616949327277483	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.533090627724779	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.455449410561251	bayes_pls_golite062009
RNA binding	0.417524996559564	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.364369105571521	bayes_pls_golite062009
tRNA (guanine) methyltransferase activity	0.203168546434167	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: