YRC Public Data Repository - Protein Structure Prediction

Protein:	phf1
Organism:	Schizosaccharomyces pombe
Length:	461 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for phf1.

Description	E-value	Query Range	Subject Range
ash2 - Ash2-trithorax family protein ASH2_SCHPO - Set1 complex component ash2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ash2 PE=3 SV=1	199.0	[0..162]	[456..14]
gi\|40788921 - gi\|40788921\|dbj\|BAA13241.2\| KIAA0234 [Homo sapiens]	188.0	[0..8]	[361..109]
gi\|2143425, gi\|6... - gi\|603862\|emb\|CAA82759.1\| unknown [Mus musculus domesticus], pir\|\|I48775 Smcx protein (escapes X-chr...	179.0	[0..47]	[361..140]
gi\|109510615 - gi\|109510615\|ref\|XP_241817.4\| PREDICTED: similar to Jumonji/ARID domain-containing protein 1C (SmcX ...	179.0	[0..47]	[361..175]
KDM5C_CANLF - Lysine-specific demethylase 5C OS=Canis lupus familiaris GN=KDM5C PE=2 SV=1	178.0	[0..47]	[361..175]
gi\|5823131, gi\|2... - gi\|5823131\|gb\|AAD53049.1\|AF127245_1 Smcx [Mus musculus], gi\|22094117\|ref\|NP_038696.1\| jumonji, AT ri...	177.0	[0..47]	[361..175]
gi\|109130908 - gi\|109130908\|ref\|XP_001090508.1\| PREDICTED: similar to Smcx homolog, X chromosome [Macaca mulatta]	177.0	[0..47]	[361..175]

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Predicted Domain #1

Region A:
Residues: [1-79]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQKNFFDEG KSYGVNDYAG FHFENGADSS LPQVSAQGVV RETDSSNFDA SPVASGSGIS  60
   61 DVGPFGADFH QLQQHVQTP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [80-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YGGMTMPASS SSGATSVPPE QDPSLSVSFN RLPKSASTKT KNGRIRSSRR EDDNRIPFYD  60
   61 LDVAEGAEDD LQEDFHVEGM KTKSGRKIQR PVAYNPNATA LKRKSRKVDM VTLCSVCQRG 120
  121 HSPLSNRIVF CDGCNSPYHQ LCHHPPIDDA TVQDVDAEWF CMKCQYRRAK QPLETGMTAQ 180
  181 DLGLSESDKK MYLSSLPTPH LADLILFCEK SYPSLPIYNP RTRELLGEIR HQLLVSSERQ 240
  241 QISLQERLHA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.045757
Match:	1jv2B
Description:	Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [330-461]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQDEAPSDEP APVPYTASYV ANSGTLYDYP TLIRLAIRNT LSPSKDEIFN WLAQNVPLLP  60
   61 TFHDSASEAI RWMVNKGQLV RSGSIYQIAT VEEYPHLQPS LLPTFQRNRK VPKLVPVSFP 120
  121 TDDPQNLCAT VL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.229	0.958	response to heat	a.4.5	"Winged helix" DNA-binding domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits