YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC2F3.05c
Organism:	Schizosaccharomyces pombe
Length:	275 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC2F3.05c.

Description	E-value	Query Range	Subject Range
gi\|56378939, gi\|... - gi\|56419097\|ref\|YP_146415.1\| plant-metabolite dehydrogenase [Geobacillus kaustophilus HTA426], gi\|56...	286.0	[0..2]	[271..4]
gi\|56963875, gi\|... - gi\|56963875\|ref\|YP_175606.1\| oxidoreductase [Bacillus clausii KSM-K16], gi\|56910118\|dbj\|BAD64645.1\| ...	279.0	[0..6]	[270..4]
gi\|14330324, gi\|... - gi\|45382879\|ref\|NP_989960.1\| aldo-keto reductase family 1, member B10 [Gallus gallus], gi\|14330324\|e...	279.0	[0..1]	[270..1]
gi\|56554308, gi\|... - gi\|56554308\|pdb\|1VP5\|B Chain B, Crystal Structure Of 2,5-Diketo-D-Gluconic Acid Reductase (Tm1009) F...	279.0	[0..1]	[264..13]
gi\|89097650, gi\|... - gi\|89097650\|ref\|ZP_01170538.1\| YvgN [Bacillus sp. NRRL B-14911], gi\|89087509\|gb\|EAR66622.1\| YvgN [Ba...	278.0	[0..2]	[271..5]
gi\|68055006, gi\|... - gi\|68055006\|ref\|ZP_00539155.1\| 2,5-didehydrogluconate reductase [Exiguobacterium sibiricum 255-15], ...	278.0	[0..6]	[273..4]
gi\|46907056, gi\|... - gi\|46907056\|ref\|YP_013445.1\| aldo/keto reductase family oxidoreductase [Listeria monocytogenes str. ...	278.0	[0..2]	[271..3]
gi\|165871533, gi... - gi\|165871533\|ref\|ZP_02216179.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|228931697, gi... - gi\|228931697\|ref\|ZP_04094602.1\| YtbE (Aldo/keto reductase YtbE) [Bacillus thuringiensis serovar anda... gi\|167530510, gi... - gi\|167634196\|ref\|ZP_02392518.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|227812869, gi... - gi\|227812869\|ref\|YP_002812878.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str.... gi\|167511749, gi... - gi\|167640347\|ref\|ZP_02398612.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|170668284, gi... - gi\|170687757\|ref\|ZP_02878972.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|47500602, gi\|... - gi\|47525454\|ref\|YP_016803.1\| aldo/keto reductase family oxidoreductase [Bacillus anthracis str. 'Ame... gi\|170707850, gi... - gi\|170707850\|ref\|ZP_02898300.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|30253703, gi\|... - gi\|30260382\|ref\|NP_842759.1\| aldo/keto reductase family oxidoreductase [Bacillus anthracis str. Ames... gi\|172081423, gi... - gi\|177653383\|ref\|ZP_02935593.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str. ... gi\|65317637, gi\|... - gi\|65317637\|ref\|ZP_00390596.1\| COG0656: Aldo/keto reductases, related to diketogulonate reductase [B... gi\|190561558, gi... - gi\|190567431\|ref\|ZP_03020345.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis Tsian... gi\|218901397, gi... - gi\|218901397\|ref\|YP_002449231.1\| oxidoreductase, aldo/keto reductase family [Bacillus cereus AH820],... gi\|254756908 - gi\|254756908\|ref\|ZP_05208936.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|254754860 - gi\|254754860\|ref\|ZP_05206895.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|254739764 - gi\|254739764\|ref\|ZP_05197457.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|49183230, gi\|... - gi\|49183230\|ref\|YP_026482.1\| aldo/keto reductase family oxidoreductase [Bacillus anthracis str. Ster... gi\|254734982 - gi\|254734982\|ref\|ZP_05192694.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|254723618 - gi\|254723618\|ref\|ZP_05185405.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|254686541 - gi\|254686541\|ref\|ZP_05150400.1\| oxidoreductase, aldo/keto reductase family protein [Bacillus anthrac... gi\|229268007, gi... - gi\|229603599\|ref\|YP_002864838.1\| oxidoreductase, aldo/keto reductase family [Bacillus anthracis str.... gi\|229119857, gi... - gi\|229119857\|ref\|ZP_04249117.1\| YtbE (Aldo/keto reductase YtbE) [Bacillus cereus 95/8201], gi\|228663...	276.0	[0..2]	[271..6]
gi\|74494062, gi\|... - gi\|75758435\|ref\|ZP_00738557.1\| Aldo/keto reductase family [Bacillus thuringiensis serovar israelensi... gi\|228860692, gi... - gi\|228898939\|ref\|ZP_04063218.1\| YtbE (Aldo/keto reductase YtbE) [Bacillus thuringiensis IBL 4222], g...	276.0	[0..2]	[271..6]

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Predicted Domain #1

Region A:
Residues: [1-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGSFVKLNN GLKCPQFAYG SYMVNRTKCF DSVYAALQCG YRHIDSAQMY HNEADCGRAI  60
   61 LKFMEETGTK REDIWFTSKL NDLSGYKSTL SSIDASVKAC GLGYIDLFLL HSPYGDRIES 120
  121 WKALEKGVEE GKLRAIGVSN FGPHHIQELL DSHPKIIPCV NQIELHPFCS QQKVVDYCES 180
  181 KGIQLAAYAP LVHGEKFGNK QLLAIASKYN KSEAQIMIRY CLQRGFIVLP KSSTPRRIKE 240
  241 NGDVFDFEIS KEDMEKLYNL DEDYHSDWNP CVSPL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.09691
Match:	1vp5A
Description:	Crystal structure of 2,5-diketo-D-gluconic acid reductase (TM1009) from Thermotoga maritima at 2.40 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldehyde reductase activity	5.07106269693426	bayes_pls_golite062009
L-glucuronate reductase activity	4.06568552614053	bayes_pls_golite062009
arabinose reductase activity	3.28910924444005	bayes_pls_golite062009
xylose reductase activity	3.28910924444005	bayes_pls_golite062009
glucose 1-dehydrogenase (NADP+) activity	2.68048267823456	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	2.43245618396666	bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	2.43245618396666	bayes_pls_golite062009
alpha-keto ester reductase activity	2.31616201247794	bayes_pls_golite062009
alpha-keto amide reductase activity	2.31616201247794	bayes_pls_golite062009
steroid dehydrogenase activity	2.19555484888528	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.87468990921314	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
glucose 1-dehydrogenase activity	1.55697325009049	bayes_pls_golite062009
bile acid transmembrane transporter activity	1.47447940903315	bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity	1.45034485133104	bayes_pls_golite062009
binding	1.3044513338497	bayes_pls_golite062009
bile acid binding	1.28757511368757	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
oxidoreductase activity	1.22645031212774	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.20678148401125	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.19919645230426	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-CH group of donors	1.15597377782029	bayes_pls_golite062009
3-oxo-5-beta-steroid 4-dehydrogenase activity	1.15597377782029	bayes_pls_golite062009
protein binding	1.06359558718341	bayes_pls_golite062009
transmembrane transporter activity	1.03420335553507	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.868027162240181	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.86591084281532	bayes_pls_golite062009
substrate-specific transporter activity	0.783004917746429	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.544360068128604	bayes_pls_golite062009
ion transmembrane transporter activity	0.260605752589411	bayes_pls_golite062009
cation transmembrane transporter activity	0.0547047948210824	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: