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View Structure Prediction Details

Protein: SPBC19C7.08c
Organism: Schizosaccharomyces pombe
Length: 681 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC19C7.08c.

Description E-value Query
Range		 Subject
Range
gi|50510525 - gi|50510525|dbj|BAD32248.1| mKIAA0547 protein [Mus musculus]
 360.0 [0..6] [680..20]
TYW4_CANAL - tRNA wybutosine-synthesizing protein 4 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PPM2 P...
LCMT2_CANAL - Leucine carboxyl methyltransferase 2 OS=Candida albicans GN=PPM2 PE=3 SV=1
 352.0 [0..4] [679..21]
TYW4_RAT - tRNA wybutosine-synthesizing protein 4 OS=Rattus norvegicus GN=Lcmt2 PE=2 SV=1
 349.0 [0..6] [680..3]
TYW4_EMENI - tRNA wybutosine-synthesizing protein 4 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112...
LCMT2_EMENI - Leucine carboxyl methyltransferase 2 OS=Emericella nidulans GN=ppm2 PE=3 SV=3
 349.0 [0..2] [676..25]
LCMT2_EMENI - Leucine carboxyl methyltransferase 2 OS=Emericella nidulans GN=ppm2 PE=3 SV=2
 348.0 [0..2] [676..15]
LCMT2_ASHGO - Leucine carboxyl methyltransferase 2 OS=Ashbya gossypii GN=PPM2 PE=3 SV=1
TYW4_ASHGO - tRNA wybutosine-synthesizing protein 4 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 992...
 336.0 [0..4] [670..24]
gi|68366314 - gi|68366314|ref|XP_696360.1| PREDICTED: similar to leucine carboxyl methyltransferase 2 [Danio rerio...
 333.0 [0..1] [678..63]

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Predicted Domain #1
Region A:
Residues: [1-326] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKNQRKTK SKDREVRKTN DSSILSKASV EKCGYPGFTV GHSYYQPFIQ KSPRRSPSVN  60
   61 RGYWTRCMAI RFAVYQFLKN KTGKRKAIVN LGAGYDPLAF QLLSSHEYNT DDVVFYDVDY 120
  121 PETIENRVQM IRSDSFLSSI VLEDKEFDLD GTEIHTKNYH SFGCNLNLLN QLESCLEKYG 180
  181 IDYCNDAILF ISEVAAVYMP RQASEKLIRW MSKFPDAHSC FFEQIAPATF DHPFANVMVK 240
  241 HFKEWGTPLH GLYAYPTIES LKSRWVKNGW EYVEILDVCT FWNFLMDSKL KHLCEMVEPF 300
  301 DEWEEFYFFL QHYSIQHASS KLVGKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.39794
Match: 2ob2A
Description: No description for 2ob2A was found.

Predicted functions:

Term Confidence Notes
protein methyltransferase activity 5.03267617653315 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
histone methyltransferase activity 3.97658336148086 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.39429041855776 bayes_pls_golite062009
protein-arginine N-methyltransferase activity 3.26663548517117 bayes_pls_golite062009
arginine N-methyltransferase activity 3.26663548517117 bayes_pls_golite062009
RNA methyltransferase activity 3.07428840534971 bayes_pls_golite062009
transferase activity 2.926540904444 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.86617323549909 bayes_pls_golite062009
tRNA methyltransferase activity 2.5931020126592 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 2.48017990451667 bayes_pls_golite062009
rRNA methyltransferase activity 2.29640050660273 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 1.91133457052099 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 1.69391860928068 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 1.15089820497406 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
binding 0.777596419415505 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.533090627724779 bayes_pls_golite062009
lysine N-methyltransferase activity 0.469870476227704 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.469870476227704 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.469870476227704 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.455449410561251 bayes_pls_golite062009
RNA binding 0.417524996559564 bayes_pls_golite062009
tRNA (guanine) methyltransferase activity 0.203168546434167 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [327-681] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLVESPDPCM QYIRYVKSEI IFNNSPLTLR NSIYSLKRTD LPACLKELPS LRLPAVCDLD  60
   61 DSVIVQGGLS TAGRSKDAYL ISEKDDGSIM KITTDSLTSC MGQSVVSIDK KTCMFIGGRE 120
  121 SPKKILSSCI YFADGNWSDF PSLPYASHRA SSVSIKHNGS SYVVLLAGKP FGGCLIWSDS 180
  181 KRKWNTLKCK DPLFYSRWGA CLHWSSKLKK GILCGGMNEL NEPVREVLEW EMVLRDDDHF 240
  241 EIVTRVLNFD VQVEILLSRI GSKVVFFGDD SKPIIVGGAA VFRTILWEEE SVCINMNDYS 300
  301 VTGVCIEETE KRPVFTMFGI SGMGNHLQIF GGGCICFSFG SCLNENATFY KLVSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 1x2jA
Description: Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle