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View Structure Prediction Details

Protein: SPBC3D6.13c
Organism: Schizosaccharomyces pombe
Length: 726 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC3D6.13c.

Description E-value Query
Range
Subject
Range
gi|74000349 - gi|74000349|ref|XP_535453.2| PREDICTED: similar to protein disulfide isomerase-associated 3 precurso...
367.0 [0..283] [712..209]
gi|112180560 - gi|112180560|gb|AAH36000.3| PDIA3 protein [Homo sapiens]
350.0 [0..281] [712..59]
gi|45361505, gi|... - gi|89268664|emb|CAJ83104.1| protein disulfide isomerase family A, member 3 [Xenopus tropicalis], gi|...
349.0 [0..280] [710..22]
gi|114670980 - gi|114670980|ref|XP_001164327.1| PREDICTED: prolyl 4-hydroxylase, beta subunit isoform 5 [Pan troglo...
345.0 [0..278] [724..21]
gi|148226947, gi... - gi|28302197|gb|AAH46707.1| Grp58-prov protein [Xenopus laevis], gi|148226947|ref|NP_001080051.1| glu...
345.0 [0..280] [720..23]
gi|60653955, gi|... - gi|60653957|gb|AAX29671.1| glucose regulated protein 58kDa [synthetic construct], gi|60653955|gb|AAX...
344.0 [0..281] [712..25]
PDIA3_CHICK - Protein disulfide-isomerase A3 OS=Gallus gallus GN=PDIA3 PE=2 SV=1
343.0 [0..281] [710..26]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSNTFGSVM RISWVVAFIT MVQTLVSGVP LTDNDLESEV SKGTWFIKYY LPSCGACKRL  60
   61 GPMWDNMVEK AKEQVEGSNF HFGEVDCSKE LSSCANIRAV PTLYLYQNGE IVEEVPFGAS 120
  121 TSEASLLDFV ETHLNPDTDP DIP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.0
Match: 1mekA
Description: HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein disulfide isomerase activity 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 1.83987272812734 bayes_pls_golite062009
intramolecular oxidoreductase activity 1.5535855642475 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
binding 0.630214408223227 bayes_pls_golite062009
hydrolase activity 0.343949262540688 bayes_pls_golite062009
protein binding 0.034515546627104 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [144-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDEDVLTDED TEEVASIQPA LSTSVSSLSL ASTAMSKSAS ASEFSGSSVT KASKKLTSSP  60
   61 TSVASKKATL SSVSKVASTS SLPVTSVSAS VDPKSAASKV QDAEFSIQTA PSFPKEKEEK 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [264-726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENTEETEESK KSINPTGTSK ALALDADIDA ALTDKEGWFI QFYSSECDDC DDVSTAWYAM  60
   61 ANRMRGKLNV AHINCAVSKR ACKQYSIQYF PTFLFFKEEA FVEYVGLPNE GDLVSFAEEA 120
  121 ANFEIREVEL LDTVNAEKNG DVFFLYFYDD DSAEYLNIIR KTGIQLLGHA NLYLTTSQQI 180
  181 AKKYRVVSFP KLIVVRDGIA SYYPAKMAQD NKDYRRILGW MKNNWLPVLP ELRTSNSKEI 240
  241 FNDESVVLFL LNPELDDFDE TKRTAQKIAT EFLDEEGRTY QSNWQKETDK KNSLVNEAEE 300
  301 KNDLEAIEAA KNFHVNGKPS PTRFAWVNGK FWAQWLRKFD IDIEATGPRV IVYNAAQDIY 360
  361 WDETAKGTPI SIEKDTVFDI IKQVETDPDH LKFKILKKNL GVEYLESYGL NIRVLYMVLG 420
  421 IVTVGILVWY FSGRRARTLQ RRRHSTPILP VSMRSTGNSG KFD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.0
Match: 2b5eA
Description: Crystal Structure of Yeast Protein Disulfide Isomerase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle