YRC Public Data Repository - Protein Structure Prediction

Protein:	gef2
Organism:	Schizosaccharomyces pombe
Length:	1101 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gef2.

Description	E-value	Query Range	Subject Range
gi\|46121791, gi\|... - gi\|46121791\|ref\|XP_385449.1\| hypothetical protein FG05273.1 [Gibberella zeae PH-1], gi\|42552666\|gb\|E...	531.0	[0..108]	[995..112]
gi\|28923526, gi\|... - gi\|32411907\|ref\|XP_326434.1\| hypothetical protein [Neurospora crassa], gi\|28923526\|gb\|EAA32703.1\| hy... gi\|85105330 - gi\|85105330\|ref\|XP_961939.1\| hypothetical protein [Neurospora crassa OR74A]	513.0	[0..108]	[968..112]
gi\|40746135, gi\|... - gi\|67515663\|ref\|XP_657717.1\| hypothetical protein AN0113.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	434.0	[0..148]	[968..158]
KALRN_RAT - Kalirin OS=Rattus norvegicus GN=Kalrn PE=1 SV=3	416.0	[0..219]	[859..1243]
gi\|82959190 - gi\|82959190\|ref\|XP_906669.1\| PREDICTED: kalirin, RhoGEF kinase isoform 6 [Mus musculus]	405.0	[0..219]	[859..260]
KALRN - kalirin, RhoGEF kinase	405.0	[0..219]	[859..1270]
gi\|74002910 - gi\|74002910\|ref\|XP_535768.2\| PREDICTED: similar to kalirin, RhoGEF kinase isoform 1 [Canis familiari...	402.0	[0..219]	[859..1292]

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Predicted Domain #1

Region A:
Residues: [1-85]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVGTMGSRA ELLAISIQFG GLWVFRDLLQ MNPLFEQDHV FCTFNHPNMG LVLISFAKVD  60
   61 GHILAAYALS KLGPDTFSIC YPFSS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [86-611]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDAFAQTLD LEWQIASMHK EAAACVYEFL CVESVCLHTG ENWRESVIEP EYASYIFDTI  60
   61 NVFQSSSLTR ELYSLGEPNG VREFVVDAIF DIKVDNSWWE DPSNSYWKTV IGSREMFEDS 120
  121 RKKTSSPSPS FASSKDAGTI PAIQKKKSLL IEMMETESTY VERLRHLVND YALPLRDLAK 180
  181 SSKKLLGLYE LNTLFPPCLN KLIQLNSAFL DEFEAIMSDL NFEDIDEKKF EEIDLRLACC 240
  241 FESHFFAFSQ HYPRYLEQSN DFGNVLKMAS KIPKFVEFHD QVKLNANMNV GLSQLIMEPV 300
  301 QRIPRYSLFL DQIILLTQEG ECQHTYVRSV EIIKNIAEMP TVDAEERSRI FAGLQHIIPD 360
  361 LAPNMISNSR NFIDCIDVTR EFLKNGQLHL IPYTLILFND RICLVQRRSK SSIASTILDL 420
  421 RKQNPRNSYS KEKRAQYIGS NMNEAVELTR SMVEENTIFL ISKYASSPSF FNEYPILKFR 480
  481 CDFENVRTMD RFYQSFQKAL SMNKSQPSCL SFSKLNDFVV FFNNYS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.0
Match:	2pz1A
Description:	No description for 2pz1A was found.

Predicted Domain #3

Region A:
Residues: [612-685]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFEYEKESKR SDIVCICTND ANVDKHKFLQ DGNIVITFFQ QDEDFHLSFD SWLGVSLPTE  60
   61 AVIAKEDLRE ACLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.0
Match:	1u3oA
Description:	Solution structure of rat Kalirin N-terminal SH3 domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [686-844]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLINIKRLLL CPFSNRNFSS LDLYSNLIQH LLSANSSPRK SRLSFGGRPG SPSKISLSLN  60
   61 RFYNQGGLSK SCATLPSQMY NLDHNNISQK SLKFNTHNTS KASAEKTVEH LEAFKGGFKY 120
  121 HTDLKNLLYP LSEKEKIEGD ELYDNILKET FNEELLSHY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [845-978]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPNIIYATFQ KYLSSFINRK FGVLLSSSFI QQLNTVENLN LSFNSTDAVY HLKKILQDLP  60
   61 ESSLKILENI FSIASDLLLR LPLKDQCDFV TKQLAIALAP SMFGSNAVEL VYYLAYHSDR 120
  121 IFGTVEELPT PVSP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.802	f.36.1	Neurotransmitter-gated ion-channel pransmembrane pore

Predicted Domain #6

Region A:
Residues: [979-1101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANSNNDKQLD ESKFQAIAMK EMPERHPKEI LPGQIEREAY EDLRRKYHLT LARLAQMTRL  60
   61 NEDSKKSIPL LYDRFNHDLK LIKQSVQASL IRKQCELDTA KWTLEEYESK LNAKEGCQTN 120
  121 IFI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits