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View Structure Prediction Details

Protein: gef2
Organism: Schizosaccharomyces pombe
Length: 1101 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gef2.

Description E-value Query
Range
Subject
Range
gi|46121791, gi|... - gi|46121791|ref|XP_385449.1| hypothetical protein FG05273.1 [Gibberella zeae PH-1], gi|42552666|gb|E...
531.0 [0..108] [995..112]
gi|28923526, gi|... - gi|32411907|ref|XP_326434.1| hypothetical protein [Neurospora crassa], gi|28923526|gb|EAA32703.1| hy...
gi|85105330 - gi|85105330|ref|XP_961939.1| hypothetical protein [Neurospora crassa OR74A]
513.0 [0..108] [968..112]
gi|40746135, gi|... - gi|67515663|ref|XP_657717.1| hypothetical protein AN0113.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
434.0 [0..148] [968..158]
KALRN_RAT - Kalirin OS=Rattus norvegicus GN=Kalrn PE=1 SV=3
416.0 [0..219] [859..1243]
gi|82959190 - gi|82959190|ref|XP_906669.1| PREDICTED: kalirin, RhoGEF kinase isoform 6 [Mus musculus]
405.0 [0..219] [859..260]
KALRN - kalirin, RhoGEF kinase
405.0 [0..219] [859..1270]
gi|74002910 - gi|74002910|ref|XP_535768.2| PREDICTED: similar to kalirin, RhoGEF kinase isoform 1 [Canis familiari...
402.0 [0..219] [859..1292]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVGTMGSRA ELLAISIQFG GLWVFRDLLQ MNPLFEQDHV FCTFNHPNMG LVLISFAKVD  60
   61 GHILAAYALS KLGPDTFSIC YPFSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDAFAQTLD LEWQIASMHK EAAACVYEFL CVESVCLHTG ENWRESVIEP EYASYIFDTI  60
   61 NVFQSSSLTR ELYSLGEPNG VREFVVDAIF DIKVDNSWWE DPSNSYWKTV IGSREMFEDS 120
  121 RKKTSSPSPS FASSKDAGTI PAIQKKKSLL IEMMETESTY VERLRHLVND YALPLRDLAK 180
  181 SSKKLLGLYE LNTLFPPCLN KLIQLNSAFL DEFEAIMSDL NFEDIDEKKF EEIDLRLACC 240
  241 FESHFFAFSQ HYPRYLEQSN DFGNVLKMAS KIPKFVEFHD QVKLNANMNV GLSQLIMEPV 300
  301 QRIPRYSLFL DQIILLTQEG ECQHTYVRSV EIIKNIAEMP TVDAEERSRI FAGLQHIIPD 360
  361 LAPNMISNSR NFIDCIDVTR EFLKNGQLHL IPYTLILFND RICLVQRRSK SSIASTILDL 420
  421 RKQNPRNSYS KEKRAQYIGS NMNEAVELTR SMVEENTIFL ISKYASSPSF FNEYPILKFR 480
  481 CDFENVRTMD RFYQSFQKAL SMNKSQPSCL SFSKLNDFVV FFNNYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.0
Match: 2pz1A
Description: No description for 2pz1A was found.

Predicted Domain #3
Region A:
Residues: [612-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFEYEKESKR SDIVCICTND ANVDKHKFLQ DGNIVITFFQ QDEDFHLSFD SWLGVSLPTE  60
   61 AVIAKEDLRE ACLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1u3oA
Description: Solution structure of rat Kalirin N-terminal SH3 domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [686-844]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLINIKRLLL CPFSNRNFSS LDLYSNLIQH LLSANSSPRK SRLSFGGRPG SPSKISLSLN  60
   61 RFYNQGGLSK SCATLPSQMY NLDHNNISQK SLKFNTHNTS KASAEKTVEH LEAFKGGFKY 120
  121 HTDLKNLLYP LSEKEKIEGD ELYDNILKET FNEELLSHY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [845-978]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPNIIYATFQ KYLSSFINRK FGVLLSSSFI QQLNTVENLN LSFNSTDAVY HLKKILQDLP  60
   61 ESSLKILENI FSIASDLLLR LPLKDQCDFV TKQLAIALAP SMFGSNAVEL VYYLAYHSDR 120
  121 IFGTVEELPT PVSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.802 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.802 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.779 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.769 a.26.1 4-helical cytokines
View Download 0.761 a.22.1 Histone-fold
View Download 0.759 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.759 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.759 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.702 a.118.8 TPR-like
View Download 0.684 a.24.17 Group V grass pollen allergen
View Download 0.412 a.1.1 Globin-like
View Download 0.402 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.390 d.110.4 SNARE-like
View Download 0.336 d.110.4 SNARE-like
View Download 0.329 a.73.1 Retrovirus capsid protein, N-terminal core domain

Predicted Domain #6
Region A:
Residues: [979-1101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANSNNDKQLD ESKFQAIAMK EMPERHPKEI LPGQIEREAY EDLRRKYHLT LARLAQMTRL  60
   61 NEDSKKSIPL LYDRFNHDLK LIKQSVQASL IRKQCELDTA KWTLEEYESK LNAKEGCQTN 120
  121 IFI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.784 a.4.5 "Winged helix" DNA-binding domain
View Download 0.632 a.1.1 Globin-like
View Download 0.575 a.63.1 Apolipophorin-III
View Download 0.571 a.4.5 "Winged helix" DNA-binding domain
View Download 0.557 a.4.5 "Winged helix" DNA-binding domain
View Download 0.538 a.63.1 Apolipophorin-III
View Download 0.491 a.1.1 Globin-like
View Download 0.485 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.212 a.45.1 Glutathione S-transferase (GST), C-terminal domain


YRC Informatics Platform - Version 3.0
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